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Gene Review

Apcs  -  amyloid P component, serum

Rattus norvegicus

Synonyms: Ptx2, SAP, Sap, Serum amyloid P-component
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Disease relevance of Apcs

  • Animals receiving antimannoprotein (anti-MP) and anti-aspartyl proteinase (Sap) Ab-containing vaginal fluids from rats clearing a primary C. albicans infection showed a highly significant level of protection against vaginitis compared to animals given Ab-free vaginal fluid from noninfected rats [1].
  • Among the putative virulence factors of Candida albicans, secreted aspartic proteinases (Sap, encoded by a family of at least nine genes) continue to attract the attention of many investigators studying the pathogenesis of candidiasis [2].
  • With these characteristics, rat serum amyloid P-component could prove to be an important model in the study of the relations between amyloid P-component and amyloidosis [3].

Psychiatry related information on Apcs

  • Serum amyloid P component, a member of pentraxin serum protein family, has been suggested to contribute to the progression of neurodegeneration including Alzheimer's disease by binding to beta-amyloid fibrils leading to an increased stability of the deposits against proteolytic degradation and by inducing neuronal apoptosis [4].

High impact information on Apcs


Chemical compound and disease context of Apcs

  • A degree of protection against vaginitis was also conferred by postinfectious administration of anti-Sap and anti-MP monoclonal antibodies (provided the latter were directed against mannan rather than protein epitopes of MP) and by intravaginal immunization with a highly purified, polysaccharide-free Sap preparation [1].

Biological context of Apcs


Anatomical context of Apcs


Associations of Apcs with chemical compounds


Analytical, diagnostic and therapeutic context of Apcs


  1. Protective role of antimannan and anti-aspartyl proteinase antibodies in an experimental model of Candida albicans vaginitis in rats. De Bernardis, F., Boccanera, M., Adriani, D., Spreghini, E., Santoni, G., Cassone, A. Infect. Immun. (1997) [Pubmed]
  2. Aspartyl proteinases of Candida albicans and their role in pathogenicity. De Bernardis, F., Sullivan, P.A., Cassone, A. Med. Mycol. (2001) [Pubmed]
  3. A new pentraxin (serum amyloid P-component) in the rat: evidence for two quaternary structures and effect of ligands on self-association. Pontet, M., D'Asnieres, M., Gache, D., Escaig, J., Engler, R. Biochim. Biophys. Acta (1981) [Pubmed]
  4. Glycosaminoglycans inhibit neurodegenerative effects of serum amyloid P component in vitro. Urbányi, Z., Forrai, E., Sárvári, M., Likó, I., Illés, J., Pázmány, T. Neurochem. Int. (2005) [Pubmed]
  5. Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity. Tsui, C.C., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Barnes, C., Worley, P.F. J. Neurosci. (1996) [Pubmed]
  6. Rat serum amyloid P component. Analysis of cDNA sequence and gene expression. Dowton, S.B., McGrew, S.D. Biochem. J. (1990) [Pubmed]
  7. Serum amyloid P component-induced cell death in primary cultures of rat cerebral cortex. Urbányi, Z., Lakics, V., Erdö, S.L. Eur. J. Pharmacol. (1994) [Pubmed]
  8. Induction of C-reactive protein, serum amyloid P component, and kininogens in the submandibular and lacrimal glands of rats with experimentally induced inflammation. Wei, W., Parvin, N., Tsumura, K., Akamatsu, T., Tada, J., Kanamori, N., Hosoi, K. Life Sci. (2001) [Pubmed]
  9. Serum amyloid P component induces neuronal apoptosis and beta-amyloid immunoreactivity. Urbányi, Z., László, L., Tomasi, T.B., Tóth, E., Mekes, E., Sass, M., Pázmány, T. Brain Res. (2003) [Pubmed]
  10. Elimination of neurokinin-1 receptor neurons in caudal nucleus reverses the effects of systemic bicuculline on c-Fos expression in rat trigeminal sensory nucleus: I. High intensity electrical stimulation of the trigeminal ganglion. Abe, T., Ohshita, N., Sugiyo, S., Moritani, M., Kobayashi, M., Takemura, M. Neuroscience (2005) [Pubmed]
  11. Isolation and characterization of C-reactive protein and serum amyloid P component in the rat. de Beer, F.C., Baltz, M.L., Munn, E.A., Feinstein, A., Taylor, J., Bruton, C., Clamp, J.R., Pepys, M.B. Immunology (1982) [Pubmed]
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