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Gene Review

Apcs  -  serum amyloid P-component

Mus musculus

Synonyms: Ptx2, SAP, Sap, Serum amyloid P-component
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Disease relevance of Apcs


Psychiatry related information on Apcs


High impact information on Apcs


Chemical compound and disease context of Apcs


Biological context of Apcs


Anatomical context of Apcs

  • Spleens were examined for Congo red staining and serum amyloid A, serum amyloid P component, and apoE immunostaining [20].
  • Ptx1 expression overlaps with that of Ptx2 in stomodeum and in posterior left lateral plate mesoderm [21].
  • Ptx2 is expressed in both developing and adult pituitary gland, eye and brain tissues, suggesting an important role in development and maintenance of anterior structures [22].
  • The pentraxins, C-reactive protein and serum amyloid P component, are cleared and catabolized by hepatocytes in vivo [23].
  • This impairment correlates with decreased circular transcript levels of Ialpha, Igamma2a, Igamma2b, and Igamma3 after stimulation, which indicate a defective Ig switch recombination in Sap-deficient B cells [24].

Associations of Apcs with chemical compounds


Other interactions of Apcs


Analytical, diagnostic and therapeutic context of Apcs


  1. Serum amyloid P component enhances induction of murine amyloidosis. Togashi, S., Lim, S.K., Kawano, H., Ito, S., Ishihara, T., Okada, Y., Nakano, S., Kinoshita, T., Horie, K., Episkopou, V., Gottesman, M.E., Costantini, F., Shimada, K., Maeda, S. Lab. Invest. (1997) [Pubmed]
  2. Serological evidence for an inflammatory response in murine scrapie. Coe, J.E., Race, R.E., Ross, M.J. J. Infect. Dis. (2001) [Pubmed]
  3. Influenza virus infection is not affected by serum amyloid P component. Herbert, J., Hutchinson, W.L., Carr, J., Ives, J., Jakob-Roetne, R., Yamamura, K., Suzuki, M., Pepys, M.B. Mol. Med. (2002) [Pubmed]
  4. Mice lacking serum amyloid P component do not necessarily develop severe autoimmune disease. Soma, M., Tamaoki, T., Kawano, H., Ito, S., Sakamoto, M., Okada, Y., Ozaki, Y., Kanba, S., Hamada, Y., Ishihara, T., Maeda, S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination? Gillmore, J.D., Hutchinson, W.L., Herbert, J., Bybee, A., Mitchell, D.A., Hasserjian, R.P., Yamamura, K., Suzuki, M., Sabin, C.A., Pepys, M.B. Immunology (2004) [Pubmed]
  6. Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model. Shi, J., Perry, G., Aliev, G., Smith, M.A., Ashe, K.H., Friedland, R.P. Neuroreport (1999) [Pubmed]
  7. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D.T., Back, S.H., Kaufman, R.J. Cell (2006) [Pubmed]
  8. Avoiding the effect of linked genes is crucial to elucidate the role of Apcs in autoimmunity. Tamaoki, T., Tezuka, H., Okada, Y., Ito, S., Shimura, H., Sakamoto, M., Endo, T., Ozaki, Y., Kanba, S., Maeda, S. Nat. Med. (2005) [Pubmed]
  9. Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Pepys, M.B., Herbert, J., Hutchinson, W.L., Tennent, G.A., Lachmann, H.J., Gallimore, J.R., Lovat, L.B., Bartfai, T., Alanine, A., Hertel, C., Hoffmann, T., Jakob-Roetne, R., Norcross, R.D., Kemp, J.A., Yamamura, K., Suzuki, M., Taylor, G.W., Murray, S., Thompson, D., Purvis, A., Kolstoe, S., Wood, S.P., Hawkins, P.N. Nature (2002) [Pubmed]
  10. Specific localization and imaging of amyloid deposits in vivo using 123I-labeled serum amyloid P component. Hawkins, P.N., Myers, M.J., Epenetos, A.A., Caspi, D., Pepys, M.B. J. Exp. Med. (1988) [Pubmed]
  11. Binding specificity of serum amyloid P component for the pyruvate acetal of galactose. Hind, C.R., Collins, P.M., Renn, D., Cook, R.B., Caspi, D., Baltz, M.L., Pepys, M.B. J. Exp. Med. (1984) [Pubmed]
  12. Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen. Noursadeghi, M., Bickerstaff, M.C., Gallimore, J.R., Herbert, J., Cohen, J., Pepys, M.B. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  13. Serum amyloid P component and autoimmune parameters in the assessment of arthritis activity in MRL/lpr/lpr mice. Rordorf-Adam, C., Serban, D., Pataki, A., Grüninger, M. Clin. Exp. Immunol. (1985) [Pubmed]
  14. Female protein, amyloidosis, and hormonal carcinogenesis in Turkish hamster: differences from Syrian hamster. Coe, J.E., Cieplak, W., Hadlow, W.J., Ross, M.J. Am. J. Physiol. (1997) [Pubmed]
  15. Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and alpha-spectrin on mouse chromosome 1. Kingsmore, S.F., Snoddy, J., Choubey, D., Lengyel, P., Seldin, M.F. Immunogenetics (1989) [Pubmed]
  16. Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1. Mortensen, R.F., Le, P.T., Taylor, B.A. Immunogenetics (1985) [Pubmed]
  17. Serum amyloid P component and C-reactive protein mediate phagocytosis through murine Fc gamma Rs. Mold, C., Gresham, H.D., Du Clos, T.W. J. Immunol. (2001) [Pubmed]
  18. Isolation and analysis of murine serum amyloid P component cDNA clones. Mole, J.E., Beaulieu, B.L., Geheran, C.A., Carnazza, J.A., Anderson, J.K. J. Immunol. (1988) [Pubmed]
  19. Acute phase proteins in salmonids: evolutionary analyses and acute phase response. Jensen, L.E., Hiney, M.P., Shields, D.C., Uhlar, C.M., Lindsay, A.J., Whitehead, A.S. J. Immunol. (1997) [Pubmed]
  20. Association of apolipoprotein E with murine amyloid A protein amyloid. Kindy, M.S., King, A.R., Perry, G., de Beer, M.C., de Beer, F.C. Lab. Invest. (1995) [Pubmed]
  21. Hindlimb patterning and mandible development require the Ptx1 gene. Lanctôt, C., Moreau, A., Chamberland, M., Tremblay, M.L., Drouin, J. Development (1999) [Pubmed]
  22. Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation. Gage, P.J., Camper, S.A. Hum. Mol. Genet. (1997) [Pubmed]
  23. The pentraxins, C-reactive protein and serum amyloid P component, are cleared and catabolized by hepatocytes in vivo. Hutchinson, W.L., Noble, G.E., Hawkins, P.N., Pepys, M.B. J. Clin. Invest. (1994) [Pubmed]
  24. Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap. Al-Alem, U., Li, C., Forey, N., Relouzat, F., Fondanèche, M.C., Tavtigian, S.V., Wang, Z.Q., Latour, S., Yin, L. Blood (2005) [Pubmed]
  25. Expression of a biologically active recombinant mouse IL-1 receptor antagonist and its use in vivo to modulate aspects of the acute phase response. Grehan, S., Uhlar, C.M., Sim, R.B., Herbert, J., Whitehead, A.S. J. Immunol. (1997) [Pubmed]
  26. The role of fibronectin in the development of experimental amyloidosis. Evidence of immunohistochemical codistribution and binding property with serum amyloid protein A. Kawahara, E., Shiroo, M., Nakanishi, I., Migita, S. Am. J. Pathol. (1989) [Pubmed]
  27. Further characterization of amyloid-enhancing factor. Axelrad, M.A., Kisilevsky, R., Willmer, J., Chen, S.J., Skinner, M. Lab. Invest. (1982) [Pubmed]
  28. The acute phase response in parasite infection. Nippostrongylus brasiliensis in the mouse. Lamontagne, L.R., Gauldie, J., Befus, A.D., McAdam, K.P., Baltz, M.L., Pepys, M.B. Immunology (1984) [Pubmed]
  29. Lipopolysaccharide (LPS)-binding synthetic peptides derived from serum amyloid P component neutralize LPS. de Haas, C.J., van der Zee, R., Benaissa-Trouw, B., van Kessel, K.P., Verhoef, J., van Strijp, J.A. Infect. Immun. (1999) [Pubmed]
  30. DNA sequence, genomic organization, and chromosomal localization of the mouse peripheral myelin protein zero gene: identification of polymorphic alleles. You, K.H., Hsieh, C.L., Hayes, C., Stahl, N., Francke, U., Popko, B. Genomics (1991) [Pubmed]
  31. Interferons as gene activators. Indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. Choubey, D., Snoddy, J., Chaturvedi, V., Toniato, E., Opdenakker, G., Thakur, A., Samanta, H., Engel, D.A., Lengyel, P. J. Biol. Chem. (1989) [Pubmed]
  32. Involvement of CD14 and toll-like receptor 4 in the acute phase response of serum amyloid A proteins and serum amyloid P component in the liver after burn injury. Cho, K., Pham, T.N., Crivello, S.D., Jeong, J., Green, T.L., Greenhalgh, D.G. Shock (2004) [Pubmed]
  33. The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis. Van Molle, W., Hochepied, T., Brouckaert, P., Libert, C. Infect. Immun. (2000) [Pubmed]
  34. Chronic active hepatitis in transgenic mice expressing interferon-gamma in the liver. Toyonaga, T., Hino, O., Sugai, S., Wakasugi, S., Abe, K., Shichiri, M., Yamamura, K. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  35. Molecular genetics of mouse serum amyloid P component (SAP): cloning and gene mapping. Whitehead, A.S., Rits, M., Michaelson, J. Immunogenetics (1988) [Pubmed]
  36. Imaging of experimental amyloidosis with 131I-labeled serum amyloid P component. Caspi, D., Zalzman, S., Baratz, M., Teitelbaum, Z., Yaron, M., Pras, M., Baltz, M.L., Pepys, M.B. Arthritis Rheum. (1987) [Pubmed]
  37. The expression of the secreted aspartyl proteinases Sap4 to Sap6 from Candida albicans in murine macrophages. Borg-von Zepelin, M., Beggah, S., Boggian, K., Sanglard, D., Monod, M. Mol. Microbiol. (1998) [Pubmed]
  38. Quantitative Western blot assay for measurement of the murine acute phase reactant, serum amyloid P component. Griswold, D.E., Hillegass, L., Antell, L., Shatzman, A., Hanna, N. J. Immunol. Methods (1986) [Pubmed]
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