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Gene Review

GUCY2F  -  guanylate cyclase 2F, retinal

Homo sapiens

Synonyms: CYGF, GC-F, GUC2DL, GUC2F, Guanylate cyclase 2F, retinal, ...
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Disease relevance of GUCY2F

  • We identified somatic mutations in GUCY2F, EPHA3, and NTRK3 in breast, lung, and pancreatic cancers [1].
  • The major form of GCF has a molecular weight of approximately M(r) 97,000, identical to that of GCF transiently expressed in CV1 cells by the vaccinia virus system [2].
  • These findings indicate that GCF negatively regulates gene expression of not only the EGFR but also several other growth factor and receptor genes and can inhibit the growth of gastric carcinomas in immunodeficient mice [3].

High impact information on GUCY2F


Biological context of GUCY2F


Anatomical context of GUCY2F

  • In addition, GCF is a phosphoprotein, and the phosphorylated form is found to be associated with the nuclear compartment in both HUT102 and KB cells [2].
  • GCF is highly expressed in EGF receptor-negative human cell lines (HUT102, U266, and CA46) and in lower amounts in several EGF receptor-expressing cells (KB, A431, TMK, and HeLa) [2].

Associations of GUCY2F with chemical compounds

  • Both cyclases named ROS-GC1 and ROS-GC2 form a subclass of membrane bound cyclases and differ in many aspects from hormone peptide receptor guanylate cyclases [9].

Other interactions of GUCY2F


Analytical, diagnostic and therapeutic context of GUCY2F


  1. Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Wood, L.D., Calhoun, E.S., Silliman, N., Ptak, J., Szabo, S., Powell, S.M., Riggins, G.J., Wang, T.L., Yan, H., Gazdar, A., Kern, S.E., Pennacchio, L., Kinzler, K.W., Vogelstein, B., Velculescu, V.E. Hum. Mutat. (2006) [Pubmed]
  2. Biochemical characterization of human GCF transcription factor in tumor cells. Beguinot, L., Yamazaki, H., Pastan, I., Johnson, A.C. Cell Growth Differ. (1995) [Pubmed]
  3. GC factor represses transcription of several growth factor/receptor genes and causes growth inhibition of human gastric carcinoma cell lines. Kitadai, Y., Yamazaki, H., Yasui, W., Kyo, E., Yokozaki, H., Kajiyama, G., Johnson, A.C., Pastan, I., Tahara, E. Cell Growth Differ. (1993) [Pubmed]
  4. Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2. Lowe, D.G., Dizhoor, A.M., Liu, K., Gu, Q., Spencer, M., Laura, R., Lu, L., Hurley, J.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. Mapping functional domains of the guanylate cyclase regulator protein, GCAP-2. Olshevskaya, E.V., Boikov, S., Ermilov, A., Krylov, D., Hurley, J.B., Dizhoor, A.M. J. Biol. Chem. (1999) [Pubmed]
  6. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. Yang, R.B., Garbers, D.L. J. Biol. Chem. (1997) [Pubmed]
  7. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Yang, R.B., Fülle, H.J., Garbers, D.L. Genomics (1996) [Pubmed]
  8. Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase-A. Kuhn, M. Circ. Res. (2003) [Pubmed]
  9. Photoreceptor specific guanylate cyclases in vertebrate phototransduction. Koch, K.W., Duda, T., Sharma, R.K. Mol. Cell. Biochem. (2002) [Pubmed]
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