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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hsp90ab1  -  heat shock protein 90 alpha (cytosolic),...

Rattus norvegicus

Synonyms: HSP 84, HSP84, HSP90-BETA, HSP90B, HSPC2, ...
 
 
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Disease relevance of Hspcb

  • RESULTS: HSP84, HSP70, and HSP22 mRNA were increased after eight minutes but not four minutes of hyperthermia [1].
  • Cells constitutively expressing high levels of hsp90 beta also showed significantly higher survival against heat stress (21.5 +/- 3.0% v 9.8 +/- 3.7%; P < 0.05) but were not resistant to 20 hours of substrate-free hypoxia (0.5 +/- 1.0% v 2.0 +/- 1.7%) [2].
  • In order to determine whether the increase of heat shock mRNA after heat stress can be thermosensitized, we studied the induction of the mRNA of HSP68 and of HSP84 after application of step-down heating (SDH) in Reuber H35 rat hepatoma cells [3].
 

High impact information on Hspcb

  • We also show that two proteins, highly expressed in the mammary gland during lactation, HSP90-beta and annexin I, are strongly expressed in DMSO-induced LA7 cells [4].
  • The results suggest that hsp84 binds mutant p53 in a spatial and/or conformation dependent manner [5].
  • The protein was purified to homogeneity and identified as hsp84 by partial amino acid sequence analysis. hsp84 is a member of the hsp90 class of proteins [5].
  • At the non-permissive temperature, TSp53(Val-135) and hsp84 colocalized in the cytoplasm near the nuclear envelope [5].
  • Moreover, the basal synthesis of proteins inducible by heat shock (heat shock proteins) and indicated as HSP65, HSP68 and HSP84 was enhanced in thermoresistant late G1/early S phase cells as compared with thermo-sensitive G0 phase cells [6].
 

Biological context of Hspcb

 

Associations of Hspcb with chemical compounds

  • The induction of HSP84 and HSP70 was blocked by pretreatment with quercetin [1].
  • Stable colonies of primary transfectants selected for neomycin resistance showed different degrees of over-expression of hsp70i, hsp90 beta or hsp60 expression as determined by Western blotting using specific monoclonal antisera [2].
  • Treatment with DNP only slightly induces hsp68 and hsp84, whereas no detectable induction of hsps is observed after treatment with ethanol [9].
  • The up-regulated genes included cytochrome c oxidase, glutathione transferase, CuZn superoxide dismutase, genes associated with the stress response (HSP70 and HSP84) and a gene involved in DNA synthesis and repair (GADD45) [10].
 

Other interactions of Hspcb

  • Total RNA was extracted from the heart kidneys and adrenals, and the mRNA levels of hsp27, hsp70, hsp84, hsp86 and hsp105 were measured [8].

References

  1. Induction of stress response proteins and experimental renal ischemia/reperfusion. Kelly, K.J., Baird, N.R., Greene, A.L. Kidney Int. (2001) [Pubmed]
  2. Differential cytoprotection against heat stress or hypoxia following expression of specific stress protein genes in myogenic cells. Heads, R.J., Yellon, D.M., Latchman, D.S. J. Mol. Cell. Cardiol. (1995) [Pubmed]
  3. Mild step-down heating causes increased levels of HSP68 and of HSP84 mRNA and enhances thermotolerance. van Wijk, R., Ovelgönne, J.H., de Koning, E., Jaarsveld, K., van Rijn, J., Wiegant, F.A. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (1994) [Pubmed]
  4. Dome formation in cell cultures as expression of an early stage of lactogenic differentiation of the mammary gland. Zucchi, I., Bini, L., Albani, D., Valaperta, R., Liberatori, S., Raggiaschi, R., Montagna, C., Susani, L., Barbieri, O., Pallini, V., Vezzoni, P., Dulbecco, R. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell. Sepehrnia, B., Paz, I.B., Dasgupta, G., Momand, J. J. Biol. Chem. (1996) [Pubmed]
  6. Increase of thermoresistance after growth stimulation of resting Reuber H35 hepatoma cells. Alteration of nuclear characteristics, non-histone chromosomal protein phosphorylation and basal heat shock protein synthesis. van Dongen, G., Geilenkirchen, W.L., van Rijn, J., van Wijk, R. Exp. Cell Res. (1986) [Pubmed]
  7. Cloning and regulation by glucocorticoid receptor ligands of a rat hsp90. McGuire, J.A., Poellinger, L., Wikström, A.C., Gustafsson, J.A. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]
  8. Mapping of quantitative trait loci (QTL) of differential stress gene expression in rat recombinant inbred strains. Dumas, P., Sun, Y., Corbeil, G., Tremblay, S., Pausova, Z., Kren, V., Krenova, D., Pravenec, M., Hamet, P., Tremblay, J. J. Hypertens. (2000) [Pubmed]
  9. Stressor-specific induction of heat shock proteins in rat hepatoma cells. Wiegant, F.A., Souren, J.E., van Rijn, J., van Wijk, R. Toxicology (1994) [Pubmed]
  10. Changes in gene expression in rat thymocytes identified by cDNA array support the occurrence of oxidative stress in early magnesium deficiency. Petrault, I., Zimowska, W., Mathieu, J., Bayle, D., Rock, E., Favier, A., Rayssiguier, Y., Mazur, A. Biochim. Biophys. Acta (2002) [Pubmed]
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