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Gene Review

wnt1  -  wingless-type MMTV integration site family...

Danio rerio

Synonyms: Protein Wnt-1, SO:0000704, WNT-1, int-1, sb:eu647, ...
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High impact information on wnt1

  • In situ hybridizations demonstrate that antibody injection causes downregulation of pax[b] transcripts in the posterior midbrain and alteration of wnt-1 and eng-2 expression in this area [1].
  • Comparison with its mouse homologue reveals that both the genomic organization of wnt-1 and the amino acid sequence of the corresponding gene product have been extensively conserved during vertebrate evolution [2].
  • Thus, the pattern of wnt-1 expression in the developing central nervous system of zebrafish is virtually identical to that seen in mouse embryos [2].
  • Transient misexpression of Lmx1b.1 or Lmx1b.2 during early MMR development induces ectopic wnt1 and fgf8 expression in the MMR, as well as throughout much of the embryo [3].
  • Ectopic boundary marker expression also occurs following knockdown of rfng, a modulator of Notch signalling required for wnt1 expression at hindbrain boundaries [4].

Biological context of wnt1

  • We show that the boundary and roof plate expression of wnt1 each contribute to upregulation of proneural and delta gene expression and neurogenesis in non-boundary regions, which in turn blocks ectopic boundary marker expression [4].
  • Molecular organisation of the tectum and tegmentum is disturbed, however, since eng, wnt1 and pax-b marker gene expression is not maintained [5].
  • Using a double-label analysis, we compare the expression patterns of wnt1 RNA and pax2 protein during zebrafish embryogenesis to determine whether they were expressed in identical or overlapping patterns in individual embryos [6].

Anatomical context of wnt1


Associations of wnt1 with chemical compounds

  • Exogenous retinoic acid, a teratogen that is known to affect the formation of the midbrain-hindbrain boundary, has a profound affect on both wnt1 and pax2 expression at gastrulation [6].
  • The loss of anterior neural tissue in mbl and lithium-treated embryos is preceded by posteriorization of presumptive anterior neuroectoderm during gastrulation, which is evident from the anterior shift of marker genes Otx2 and Wnt1 [8].

Other interactions of wnt1

  • How the positional information is translated into activation of Pax2, Wnt1 and Fgf8 expression during MHB establishment remains unclear [9].
  • Driving wnt1 expression using a heat-shock construct partially rescues metameric patterning in mib mutants [10].

Analytical, diagnostic and therapeutic context of wnt1


  1. Zebrafish pax[b] is involved in the formation of the midbrain-hindbrain boundary. Krauss, S., Maden, M., Holder, N., Wilson, S.W. Nature (1992) [Pubmed]
  2. Genomic structure and restricted neural expression of the zebrafish wnt-1 (int-1) gene. Molven, A., Njølstad, P.R., Fjose, A. EMBO J. (1991) [Pubmed]
  3. Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer. O'Hara, F.P., Beck, E., Barr, L.K., Wong, L.L., Kessler, D.S., Riddle, R.D. Development (2005) [Pubmed]
  4. Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain. Amoyel, M., Cheng, Y.C., Jiang, Y.J., Wilkinson, D.G. Development (2005) [Pubmed]
  5. Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., van Eeden, F.J., Nüsslein-Volhard, C. Development (1996) [Pubmed]
  6. Involvement of wnt1 and pax2 in the formation of the midbrain-hindbrain boundary in the zebrafish gastrula. Kelly, G.M., Moon, R.T. Dev. Genet. (1995) [Pubmed]
  7. Zebrafish aussicht mutant embryos exhibit widespread overexpression of ace (fgf8) and coincident defects in CNS development. Heisenberg, C.P., Brennan, C., Wilson, S.W. Development (1999) [Pubmed]
  8. Ectopic Wnt signal determines the eyeless phenotype of zebrafish masterblind mutant. van de Water, S., van de Wetering, M., Joore, J., Esseling, J., Bink, R., Clevers, H., Zivkovic, D. Development (2001) [Pubmed]
  9. spiel ohne grenzen/pou2 is required during establishment of the zebrafish midbrain-hindbrain boundary organizer. Belting, H.G., Hauptmann, G., Meyer, D., Abdelilah-Seyfried, S., Chitnis, A., Eschbach, C., Söll, I., Thisse, C., Thisse, B., Artinger, K.B., Lunde, K., Driever, W. Development (2001) [Pubmed]
  10. Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrain. Riley, B.B., Chiang, M.Y., Storch, E.M., Heck, R., Buckles, G.R., Lekven, A.C. Dev. Dyn. (2004) [Pubmed]
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