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Gene Review

Rnf19a  -  ring finger protein 19A

Mus musculus

Synonyms: AA032313, Dorfin, Double ring-finger protein, E3 ubiquitin-protein ligase RNF19A, Gametogenesis-expressed protein GEG-154, ...
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Disease relevance of Rnf19


High impact information on Rnf19


Biological context of Rnf19


Anatomical context of Rnf19


Regulatory relationships of Rnf19


Other interactions of Rnf19


Analytical, diagnostic and therapeutic context of Rnf19

  • Here we report on the identification of an Mr 51,000 protein (p51) that is homogeneously distributed in the XY body of rodents as shown by immunocytochemistry with the novel monoclonal antibody 4EC [16].
  • In the present study, we investigated the fine immunolocalization of XMR in the XY body by laser confocal and electron microscopy [15].
  • Using laser confocal microscopy we characterized the distribution of XMR in the XY body relative to the XY chromatin and the nucleolus [17].


  1. Impact of trisomy on fertility and meiosis in male mice. Davisson, M., Akeson, E., Schmidt, C., Harris, B., Farley, J., Handel, M.A. Hum. Reprod. (2007) [Pubmed]
  2. Mouse Sycp1 functions in synaptonemal complex assembly, meiotic recombination, and XY body formation. de Vries, F.A., de Boer, E., van den Bosch, M., Baarends, W.M., Ooms, M., Yuan, L., Liu, J.G., van Zeeland, A.A., Heyting, C., Pastink, A. Genes Dev. (2005) [Pubmed]
  3. Telomere-independent homologue pairing and checkpoint escape of accessory ring chromosomes in male mouse meiosis. Voet, T., Liebe, B., Labaere, C., Marynen, P., Scherthan, H. J. Cell Biol. (2003) [Pubmed]
  4. Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis. Khalil, A.M., Boyar, F.Z., Driscoll, D.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Baarends, W.M., Wassenaar, E., van der Laan, R., Hoogerbrugge, J., Sleddens-Linkels, E., Hoeijmakers, J.H., de Boer, P., Grootegoed, J.A. Mol. Cell. Biol. (2005) [Pubmed]
  6. XYbp, a novel RING-finger protein, is a component of the XY body of spermatocytes and centrosomes. Párraga, M., del Mazo, J. Mech. Dev. (2000) [Pubmed]
  7. BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Turner, J.M., Aprelikova, O., Xu, X., Wang, R., Kim, S., Chandramouli, G.V., Barrett, J.C., Burgoyne, P.S., Deng, C.X. Curr. Biol. (2004) [Pubmed]
  8. Localisation of histone macroH2A1.2 to the XY-body is not a response to the presence of asynapsed chromosome axes. Hoyer-Fender, S., Czirr, E., Radde, R., Turner, J.M., Mahadevaiah, S.K., Pehrson, J.R., Burgoyne, P.S. J. Cell. Sci. (2004) [Pubmed]
  9. Chromosomally derived sterile mice have a 'fertile' active XY chromatin conformation but no XY body. Richler, C., Uliel, E., Rosenmann, A., Wahrman, J. Chromosoma (1989) [Pubmed]
  10. Histone macroH2A1.2 is concentrated in the XY-body by the early pachytene stage of spermatogenesis. Hoyer-Fender, S., Costanzi, C., Pehrson, J.R. Exp. Cell Res. (2000) [Pubmed]
  11. The murine nuclear orphan receptor GCNF is expressed in the XY body of primary spermatocytes. Bauer, U.M., Schneider-Hirsch, S., Reinhardt, S., Benavente, R., Maelicke, A. FEBS Lett. (1998) [Pubmed]
  12. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. O'Carroll, D., Scherthan, H., Peters, A.H., Opravil, S., Haynes, A.R., Laible, G., Rea, S., Schmid, M., Lebersorger, A., Jerratsch, M., Sattler, L., Mattei, M.G., Denny, P., Brown, S.D., Schweizer, D., Jenuwein, T. Mol. Cell. Biol. (2000) [Pubmed]
  13. SUMO modified proteins localize to the XY body of pachytene spermatocytes. Rogers, R.S., Inselman, A., Handel, M.A., Matunis, M.J. Chromosoma (2004) [Pubmed]
  14. Xist RNA is associated with the transcriptionally inactive XY body in mammalian male meiosis. Ayoub, N., Richler, C., Wahrman, J. Chromosoma (1997) [Pubmed]
  15. XMR is associated with the asynapsed segments of sex chromosomes in the XY body of mouse primary spermatocytes. Escalier, D., Garchon, H.J. Chromosoma (2000) [Pubmed]
  16. An Mr 51,000 protein of mammalian spermatogenic cells that is common to the whole XY body and centromeric heterochromatin of autosomes. Smith, A., Benavente, R. Chromosoma (1995) [Pubmed]
  17. XMR, a dual location protein in the XY pair and in its associated nucleolus in mouse spermatocytes. Escalier, D., Garchon, H.J. Mol. Reprod. Dev. (2005) [Pubmed]
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