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Gene Review

HNRNPL  -  heterogeneous nuclear ribonucleoprotein L

Homo sapiens

Synonyms: HNRPL, Heterogeneous nuclear ribonucleoprotein L, P/OKcl.14, hnRNP L, hnRNP-L
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Disease relevance of HNRPL


High impact information on HNRPL

  • Recombinant hnRNP L was shown to bind with high sequence specificity to this RNA sequence element [4].
  • Sequence comparisons indicate that pPTB is distantly related to the hnRNP L protein and that these two proteins should be considered as members of a novel family of RNA-binding proteins [5].
  • We hypothesize that hnRNP L may be involved in the regulation of many other genes containing CA repeats or A/C-rich enhancers [6].
  • Thus, we conclude that hnRNP L plays roles in enhancing stability, polyadenylation, and nucleocytoplasmic export; it does so, at least in part, by directly recruiting to intronless PPE-containing RNAs cofactors normally recruited to intron-containing RNAs [7].
  • Furthermore, when M21 cells transfected with antisense oligodeoxyribonucleotide to the hnRNP L RNA-binding site, the VEGF mRNA half-life was significantly reduced under hypoxic conditions [1].

Biological context of HNRPL

  • Our results support the possibility that the APE1 gene is down-regulated by its own product, which would be the first such example of the regulation of a DNA repair enzyme, and identify a novel function of hnRNP-L in transcriptional regulation [8].
  • The CA repeat enhancer requires for its activity specific binding of hnRNP L [9].
  • A transfection study using a series of deletion mutants of hnRNP L fused to indicated that the N-terminal portions of RRM(RNA recognition motif)1, RRM3 and RRM2 are involved in localization of hnRNP L [3].

Anatomical context of HNRPL

  • Both PTB and hnRNP L were found to localize in the nucleoplasm, excepting the nucleoli, in HeLa cells by the green fluorescent protein (GFP)-fused protein detection method [10].

Associations of HNRPL with chemical compounds

  • hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo [11].

Physical interactions of HNRPL


Other interactions of HNRPL

  • The distinguishing genes are involved in neural growth (FGFR1) and in nuclear trafficking (HNRPL, KPNB1) [12].

Analytical, diagnostic and therapeutic context of HNRPL


  1. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. Shih, S.C., Claffey, K.P. J. Biol. Chem. (1999) [Pubmed]
  2. Interaction of cellular proteins with the 5' end of Norwalk virus genomic RNA. Gutiérrez-Escolano, A.L., Brito, Z.U., del Angel, R.M., Jiang, X. J. Virol. (2000) [Pubmed]
  3. hnRNP L enhances sensitivity of the cells to KW-2189. Taguchi, F., Kusaba, H., Asai, A., Iwamoto, Y., Yano, K., Nakano, H., Mizukami, T., Saijo, N., Kato, H., Nishio, K. Int. J. Cancer (2004) [Pubmed]
  4. HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression. Liu, X., Mertz, J.E. Genes Dev. (1995) [Pubmed]
  5. Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Gil, A., Sharp, P.A., Jamison, S.F., Garcia-Blanco, M.A. Genes Dev. (1991) [Pubmed]
  6. HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Hui, J., Stangl, K., Lane, W.S., Bindereif, A. Nat. Struct. Biol. (2003) [Pubmed]
  7. Binding of hnRNP L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs. Guang, S., Felthauser, A.M., Mertz, J.E. Mol. Cell. Biol. (2005) [Pubmed]
  8. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. Kuninger, D.T., Izumi, T., Papaconstantinou, J., Mitra, S. Nucleic Acids Res. (2002) [Pubmed]
  9. Novel functional role of CA repeats and hnRNP L in RNA stability. Hui, J., Reither, G., Bindereif, A. RNA (2003) [Pubmed]
  10. Polypyrimidine tract-binding protein interacts with HnRNP L. Hahm, B., Cho, O.H., Kim, J.E., Kim, Y.K., Kim, J.H., Oh, Y.L., Jang, S.K. FEBS Lett. (1998) [Pubmed]
  11. hnRNP A2 and hnRNP L bind the 3'UTR of glucose transporter 1 mRNA and exist as a complex in vivo. Hamilton, B.J., Nichols, R.C., Tsukamoto, H., Boado, R.J., Pardridge, W.M., Rigby, W.F. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  12. Lymphoid gene expression as a predictor of risk of secondary brain tumors. Edick, M.J., Cheng, C., Yang, W., Cheok, M., Wilkinson, M.R., Pei, D., Evans, W.E., Kun, L.E., Pui, C.H., Relling, M.V. Genes Chromosomes Cancer (2005) [Pubmed]
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