The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

cdtB  -  cytolethal distending toxin, subunit B

Campylobacter jejuni RM1221

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of cdtB

  • Although the cdtB gene was detected from 100% of the Campylobacter jejuni and Campylobacter coli isolates we observed three different morphological pictures on the cells [1].
  • We have previously shown that Actinobacillus actinomycetemcomitans produces an immunosuppressive factor that is encoded by the cdtB gene, which is homologous to a family of cytolethal distending toxins (Cdt) expressed by several gram-negative bacteria [2].
  • Wild-type C. jejuni caused moderately severe gastritis and proximal duodenitis in 3X mice that were more severe than the gastrointestinal lesions caused by the C. jejuni cdtB mutant [3].
  • When orally administered to adult severe combined immunodeficient (SCID) mice, C. jejuni cdtB mutant strains were unaffected in enteric colonisation abilities but demonstrated impaired invasiveness into blood, spleen and liver tissues [4].

High impact information on cdtB

  • The first type of mutation comprised a 667-bp deletion across cdtA and cdtB and considerable degeneration in the remainder of the cdt locus [5].
  • Persistent colonization of NF-kappaB-deficient mice with the wild type and the C. jejuni cdtB mutant was associated with significantly impaired IgG and IgG2a humoral responses (P < 0.001), which is consistent with an innate or adaptive immune system defect(s) [3].
  • The C. jejuni 81-176 cdtB probe did not hybridize to DNAs from representative C. fetus, C. lari, C. "upsaliensis," and C. hyointestinalis strains, although the HeLa cell assay indicated that these strains make CDT [6].
  • Detection of cdtA, cdtB, and cdtC genes in Campylobacter jejuni by multiplex PCR [7].
  • The cadF, flaA, ceuE and cdtB genes were detected from 100% of the isolates [8].

Biological context of cdtB


Other interactions of cdtB

  • The toxin production was determined on the phenotypic level using a CHO-K1 cell culture model and on the genotypic level using PCR for detection of the cdtA, cdtB and cdtC genes [1].

Analytical, diagnostic and therapeutic context of cdtB


  1. Relationships between bacterial genotypes and in vitro virulence properties of Campylobacter jejuni and Campylobacter coli isolated from turkeys. Hänel, I., Borrmann, E., Müller, J., Alter, T. J. Appl. Microbiol. (2007) [Pubmed]
  2. Expression of the cytolethal distending toxin (Cdt) operon in Actinobacillus actinomycetemcomitans: evidence that the CdtB protein is responsible for G2 arrest of the cell cycle in human T cells. Shenker, B.J., Hoffmaster, R.H., McKay, T.L., Demuth, D.R. J. Immunol. (2000) [Pubmed]
  3. Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Fox, J.G., Rogers, A.B., Whary, M.T., Ge, Z., Taylor, N.S., Xu, S., Horwitz, B.H., Erdman, S.E. Infect. Immun. (2004) [Pubmed]
  4. Characterisation of cytolethal distending toxin (CDT) mutants of Campylobacter jejuni. Purdy, D., Buswell, C.M., Hodgson, A.E., McAlpine, K., Henderson, I., Leach, S.A. J. Med. Microbiol. (2000) [Pubmed]
  5. Cytolethal distending toxin (CDT)-negative Campylobacter jejuni strains and anti-CDT neutralizing antibodies are induced during human infection but not during colonization in chickens. Abuoun, M., Manning, G., Cawthraw, S.A., Ridley, A., Ahmed, I.H., Wassenaar, T.M., Newell, D.G. Infect. Immun. (2005) [Pubmed]
  6. Prevalence of cytolethal distending toxin production in Campylobacter jejuni and relatedness of Campylobacter sp. cdtB gene. Pickett, C.L., Pesci, E.C., Cottle, D.L., Russell, G., Erdem, A.N., Zeytin, H. Infect. Immun. (1996) [Pubmed]
  7. Detection of cdtA, cdtB, and cdtC genes in Campylobacter jejuni by multiplex PCR. Martínez, I., Mateo, E., Churruca, E., Girbau, C., Alonso, R., Fernández-Astorga, A. Int. J. Med. Microbiol. (2006) [Pubmed]
  8. PCR detection of seven virulence and toxin genes of Campylobacter jejuni and Campylobacter coli isolates from Danish pigs and cattle and cytolethal distending toxin production of the isolates. Bang, D.D., Nielsen, E.M., Scheutz, F., Pedersen, K., Handberg, K., Madsen, M. J. Appl. Microbiol. (2003) [Pubmed]
  9. Detection of seven virulence and toxin genes of Campylobacter jejuni isolates from Danish turkeys by PCR and cytolethal distending toxin production of the isolates. Bang, D.D., Borck, B., Nielsen, E.M., Scheutz, F., Pedersen, K., Madsen, M. J. Food Prot. (2004) [Pubmed]
  10. Promoter analysis of cytolethal distending toxin genes (cdtA , B, and C ) and effect of a luxS mutation on CDT production in Campylobacter jejuni. Jeon, B., Itoh, K., Ryu, S. Microbiol. Immunol. (2005) [Pubmed]
WikiGenes - Universities