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MeSH Review


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Disease relevance of Duodenitis


High impact information on Duodenitis

  • Neither cimetidine nor cigarette smoking nor ulcer healing appeared substantially to affect duodenitis and fixed deformity [6].
  • No correlation was found between the peak acid output (PAO) in response to Histalog and the severity of the gastritis or the duodenitis either before or after operation, with one exception [7].
  • AIM: To compare the efficacy of either omeprazole or ranitidine in a second-line quadruple regimen in patients with duodenal ulcer or erosive duodenitis [8].
  • Similarly, the absence of CMV and HSV DNA in CD, active peptic disease in adults, and active duodenitis in children suggests that neither virus is involved in the persistence of these inflammatory conditions [9].
  • The 4/15 H. pylori-positive patients (all of whom had associated gastritis/duodenitis) who failed antisecretory therapy responded clinically to treatment with amoxicillin plus bismuth subsalicylate [10].

Chemical compound and disease context of Duodenitis

  • Treatment with cimetidine reduced both the severity of duodenitis and the mean crypt LI [11].
  • Double-blind trial of pirenzepine versus sucralfate in the treatment of endoscopic duodenitis [12].
  • Duodenitis and secretion of O-acetylated sialomucin variants [13].
  • In the 6 children with mild gastritis, mean sucrose excretion was twice that of controls (0.060 +/- 0.024 vs. 0.029 +/- 0.018, respectively; p = 0.019) and significantly higher than the group with duodenitis (0.037 +/- 0.013; p = 0.038) [14].
  • Effects of milk, prostaglandin, and antacid on experimentally induced duodenitis in the rat. Use of myeloperoxidase as an index of inflammation [15].

Biological context of Duodenitis


Anatomical context of Duodenitis


Gene context of Duodenitis

  • The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of duodenitis may improve their clinical relevance [20].
  • Acid secretory behavior as well as gastrin levels were evaluated in 38 cases of chronic duodenitis [21].
  • BACKGROUND: Duodenal gastric metaplasia is rarely reported in untreated celiac disease, although it is seen in 60% to 100% of duodenal biopsy specimens in nonceliac patients with histologic duodenitis [22].
  • Endoscopic studies showed that ZAC reduced the inflammatory processes (gastritis and duodenitis) associated with ulcer healing [23].
  • Many of the African-American patients are recent immigrants from the Caribbean Islands. In these patients, an inverse relationship was observed between HP infection and the number of years living in the United States. Higher levels of HP infection were observed in patients with duodenitis and peptic ulcer disease [24].

Analytical, diagnostic and therapeutic context of Duodenitis

  • Ulcerative duodenitis with luminal constriction in two horses [25].
  • Congo red test was positive in 13 cases, with 9 of these showing evidence of incomplete vagotomy manifesting as erosions, duodenitis, stomal ulceration or ulcer recurrence [26].
  • Duodenal mucosal biopsy was done in both groups and histological confirmation of duodenitis was noted in 9 of the group A and in 10 of group B. Endoscopy after short-term cimetidine treatment in group A patients revealed ulcer healing in 87.5 percent and improvement of duodenitis in 50 percent [27].


  1. CD4+CD45RBHi interleukin-4 defective T cells elicit antral gastritis and duodenitis. Dohi, T., Fujihashi, K., Koga, T., Etani, Y., Yoshino, N., Kawamura, Y.I., McGhee, J.R. Am. J. Pathol. (2004) [Pubmed]
  2. Effect of Helicobacter pylori eradication on gastric metaplasia of the duodenum. Khulusi, S., Mendall, M.A., Badve, S., Patel, P., Finlayson, C., Northfield, T.C. Gut (1995) [Pubmed]
  3. The Helicobacter pylori breath test: a surrogate marker for peptic ulcer disease in dyspeptic patients. McColl, K.E., el-Nujumi, A., Murray, L., el-Omar, E., Gillen, D., Dickson, A., Kelman, A., Hilditch, T.E. Gut (1997) [Pubmed]
  4. Endoscopic appearances and histological changes in ulcer-associated duodenitis. Stephen, J.G., Lesna, M., Venables, C.W. The British journal of surgery. (1978) [Pubmed]
  5. The effects of hemodialysis on duodenal and gastric mucosal changes in uremic patients. Var, C., Gültekin, F., Candan, F., Türkay, C., Sencan, M., Içağasioğlu, S., Dökmetaş, S., Topçu, S., Içli, F., Var, F., Eğilmez, R. Clin. Nephrol. (1996) [Pubmed]
  6. Cigarette smoking and duodenal ulcer. Hull, D.H., Beale, P.J. Gut (1985) [Pubmed]
  7. Gastritis duodenitis, and circulating levels of gastrin in duodenal ulcer before and after vagotomy. Meikle, D.D., Taylor, K.B., Truelove, S.C., Whitehead, R. Gut (1976) [Pubmed]
  8. Randomized study comparing omeprazole with ranitidine as anti-secretory agents combined in quadruple second-line Helicobacter pylori eradication regimens. Michopoulos, S., Tsibouris, P., Bouzakis, H., Balta, A., Vougadiotis, J., Broutet, N., Kralios, N. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  9. Evaluation of celiac disease biopsies for adenovirus 12 DNA using a multiplex polymerase chain reaction. Vesy, C.J., Greenson, J.K., Papp, A.C., Snyder, P.J., Qualman, S.J., Prior, T.W. Mod. Pathol. (1993) [Pubmed]
  10. Esophagitis and Helicobacter pylori in children: incidence and therapeutic implications. Rosioru, C., Glassman, M.S., Halata, M.S., Schwarz, S.M. Am. J. Gastroenterol. (1993) [Pubmed]
  11. Mucosal cell proliferation in duodenal ulcer and duodenitis. Bransom, C.J., Boxer, M.E., Palmer, K.R., Clark, J.C., Underwood, J.C., Duthie, H.L. Gut (1981) [Pubmed]
  12. Double-blind trial of pirenzepine versus sucralfate in the treatment of endoscopic duodenitis. Guslandi, M., Molteni, V., Dell'Oca, M., Ballarin, E. Clinical therapeutics. (1990) [Pubmed]
  13. Duodenitis and secretion of O-acetylated sialomucin variants. Lapertosa, G., Fulcheri, E., Baracchini, P. Histopathology (1988) [Pubmed]
  14. Sucrose permeability in children with gastric damage and Helicobacter pylori infection. Vera, J.F., Gotteland, M., Chavez, E., Vial, M.T., Kakarieka, E., Brunser, O. J. Pediatr. Gastroenterol. Nutr. (1997) [Pubmed]
  15. Effects of milk, prostaglandin, and antacid on experimentally induced duodenitis in the rat. Use of myeloperoxidase as an index of inflammation. Cooper, L.C., Dial, E.J., Lichtenberger, L.M. Dig. Dis. Sci. (1990) [Pubmed]
  16. Patients with duodenitis have gastric secretory and motor functions like those of duodenal ulcer patients: results of a short-term treatment with ranitidine. Corinaldesi, R., Paternicó, A., Stanghellini, V., Di Febo, G., Biasco, G., Caló, G., Monetti, N., Tosetti, C., Barbara, L. J. Clin. Gastroenterol. (1991) [Pubmed]
  17. Measurement of tryptase in endoscopic gastroduodenal biopsies: distribution and relationship with ulcer disease. Plebani, M., Di Mario, F., Battistel, M., Basso, D., Mantovani, G., Giacomini, A., Burlina, A. Clin. Chim. Acta (1992) [Pubmed]
  18. Successful treatment with ganciclovir for cytomegalovirus duodenitis following allogenic bone marrow transplantation. Ahn, J.H., Lee, J.H., Lee, K.H., Kim, W.K., Lee, J.S., Bahng, H., Jung, H.Y., Kim, Y.S., Kim, O., Kim, S.H. Korean J. Intern. Med. (1999) [Pubmed]
  19. Effects of smoking and Helicobacter pylori on prostaglandin concentrations in gastric and duodenal mucosa of patients with duodenal ulcer and duodenitis. Bago, J., Renić, M., Kucisec, N., Culo, F., Bilić, A., Eljuga, D., Jurcić, D. Collegium antropologicum. (1997) [Pubmed]
  20. Increased PCNA/cyclin index correlates with severity of duodenitis defined by histological criteria. Domagala, W., Marlicz, K., Bielicki, D., Osborn, M. Virchows Archiv. A, Pathological anatomy and histopathology. (1993) [Pubmed]
  21. Is duodenitis always a peptic disease? Cheli, R. Am. J. Gastroenterol. (1985) [Pubmed]
  22. Gastric metaplasia: a frequently overlooked feature of duodenal biopsy specimens in untreated celiac disease. Shaoul, R., Marcon, M.A., Okada, Y., Cutz, E., Forstner, G. J. Pediatr. Gastroenterol. Nutr. (2000) [Pubmed]
  23. Zinc compounds, a new treatment in peptic ulcer. Escolar, G., Bulbena, O. Drugs under experimental and clinical research. (1989) [Pubmed]
  24. H. pylori infection and genotyping in patients undergoing upper endoscopy at inner city hospitals. Straus, E.W., Patel, H., Chang, J., Gupta, R.M., Sottile, V., Scirica, J., Tarabay, G., Iyer, S., Samuel, S., Raffaniello, R.D. Dig. Dis. Sci. (2002) [Pubmed]
  25. Ulcerative duodenitis with luminal constriction in two horses. Ettlinger, J.J., Ford, T., Palmer, J.E. J. Am. Vet. Med. Assoc. (1990) [Pubmed]
  26. Is the vagotomy complete? Qureshi, H., Maher, M., Ahmed, W., Zuberi, S.J. JPMA. The Journal of the Pakistan Medical Association. (1991) [Pubmed]
  27. Ulcer associated and nonspecific duodenitis treatment by cimetidine. Nicolopoulos, N., Vassilakis, J.S., Stathopoulos, E., Mantidis, A. Gastroenterol. Jpn. (1982) [Pubmed]
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