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Gene Review

Plc21C  -  Phospholipase C at 21C

Drosophila melanogaster

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II, CG4574, Dmel\CG4574, PLC, PLC-21, ...
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Disease relevance of Plc21C


High impact information on Plc21C

  • Pld overexpression rescues flies lacking PLC from light-induced, metarhodopsin-mediated degeneration and restores visual signaling in flies lacking the PI transfer protein, which is a key player in the replenishment of the PI 4,5-bisphosphate (PIP2) substrate used by PLC to transduce light stimuli into neurological signals [2].
  • A Drosophila gene encoding a gamma-type isozyme of phosphoinositide-specific phospholipase C (PLC) was isolated and characterized [3].
  • PLC antisense oligonucleotide-injected oocytes show Cl- current responses to IP3 that are indistinguishable from sense oligonucleotide-injected oocytes [4].
  • Xenopus oocytes exhibit a receptor-evoked Cl- current that is mediated through the activation of phospholipase C (PLC) and release of intracellular Ca2+ [4].
  • We have characterized inositol phospholipid-specific phospholipase C (PLC) isozymes in bovine retina [5].

Biological context of Plc21C


Anatomical context of Plc21C


Associations of Plc21C with chemical compounds

  • The purification of the major PLC in KCl extract from normal Drosophila heads was achieved by sequential column chromatography on DEAE-Sepharose CL-6B, Mono Q, Superose 12, Mono S, second Mono S, and second Mono Q, followed by column chromatography on Superose 12 in the presence of 1% sodium cholate [9].
  • Chromatography of a retinal homogenate on a heparin column partially resolved six peaks of PLC activity, which differed in their relative selectivities for the substrates phosphatidyl 4,5-bisphosphate (PIP2) and phosphatidylinositol (PI) [5].
  • We report here that the norpA-coded PLC modulates the 1,4-dihydropyridine (DHP)-sensitive Ca2+ channels in larval muscles [10].
  • By contrast, EGTA, failed to inhibit PLC activity when pre-loaded with Ca2+, but like BAPTA, inhibited both basal and light-induced PLC activity when introduced without Ca2+ [8].
  • Inositol phospholipid-specific phospholipase C (PLC) generates two important second messengers, inositol triphosphate and diacylglycerol [11].


  1. cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4). Alvarez, R.A., Ghalayini, A.J., Xu, P., Hardcastle, A., Bhattacharya, S., Rao, P.N., Pettenati, M.J., Anderson, R.E., Baehr, W. Genomics (1995) [Pubmed]
  2. Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid. LaLonde, M.M., Janssens, H., Rosenbaum, E., Choi, S.Y., Gergen, J.P., Colley, N.J., Stark, W.S., Frohman, M.A. J. Cell Biol. (2005) [Pubmed]
  3. Drosophila phospholipase C-gamma expressed predominantly in blastoderm cells at cellularization and in endodermal cells during later embryonic stages. Emori, Y., Sugaya, R., Akimaru, H., Higashijima, S., Shishido, E., Saigo, K., Homma, Y. J. Biol. Chem. (1994) [Pubmed]
  4. Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. Ma, H.W., Blitzer, R.D., Healy, E.C., Premont, R.T., Landau, E.M., Iyengar, R. J. Biol. Chem. (1993) [Pubmed]
  5. Purification, molecular cloning, and sequencing of phospholipase C-beta 4. Lee, C.W., Park, D.J., Lee, K.H., Kim, C.G., Rhee, S.G. J. Biol. Chem. (1993) [Pubmed]
  6. A Drosophila phospholipase C gene that is expressed in the central nervous system. Shortridge, R.D., Yoon, J., Lending, C.R., Bloomquist, B.T., Perdew, M.H., Pak, W.L. J. Biol. Chem. (1991) [Pubmed]
  7. Control of Drosophila opsin gene expression by carotenoids and retinoic acid: northern and western analyses. Picking, W.L., Chen, D.M., Lee, R.D., Vogt, M.E., Polizzi, J.L., Marietta, R.G., Stark, W.S. Exp. Eye Res. (1996) [Pubmed]
  8. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Hardie, R.C. Cell Calcium (2005) [Pubmed]
  9. Purification and partial amino acid sequences of phosphoinositide-specific phospholipase C of Drosophila eye. Toyoshima, S., Matsumoto, N., Wang, P., Inoue, H., Yoshioka, T., Hotta, Y., Osawa, T. J. Biol. Chem. (1990) [Pubmed]
  10. Modulation of the dihydropyridine-sensitive calcium channels in Drosophila by a phospholipase C-mediated pathway. Gu, G.G., Singh, S. J. Neurobiol. (1997) [Pubmed]
  11. The rat phospholipase C beta 4 gene is expressed at high abundance in cerebellar Purkinje cells. Roustan, P., Abitbol, M., Ménini, C., Ribeaudeau, F., Gérard, M., Vekemans, M., Mallet, J., Dufier, J.L. Neuroreport (1995) [Pubmed]
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