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Gene Review

Plcb1  -  phospholipase C, beta 1

Mus musculus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, 3110043I21Rik, AI132408, PLC-154, PLC-beta-1, ...
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Disease relevance of Plcb1


Psychiatry related information on Plcb1


High impact information on Plcb1


Chemical compound and disease context of Plcb1


Biological context of Plcb1


Anatomical context of Plcb1

  • PLC-beta 1 became relocated to the oocyte cortex and the nucleoplasm during the G2/M transition, mainly in the hour preceding GVBD [11].
  • Homozygous null mutation of either PLC-beta1 or mGluR5 dramatically disrupts the cytoarchitectural differentiation of 'barrels' in the mouse somatosensory cortex, despite segregation in the pattern of thalamic innervation [8].
  • Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling [15].
  • Confocal immunofluorescence imaging of peri-implantation blastocysts demonstrated that PLC-gamma2, but not PLC-gamma1 nor PLC-beta1, accumulated near the outer surface of the embryo [16].
  • The presence of G alpha q/11, PLC beta 1 and a functional IP3R in the anterior acrosomal region of mammalian sperm, as well as thapsigargin's induction of the acrosome reaction, implicate IP3-gated calcium release in the mammalian acrosome reaction [17].

Associations of Plcb1 with chemical compounds


Regulatory relationships of Plcb1


Other interactions of Plcb1


Analytical, diagnostic and therapeutic context of Plcb1


  1. Phospholipase C-beta3 mediates the thrombin-induced Ca2+ response in glial cells. Hwang, J.I., Shin, K.J., Oh, Y.S., Choi, J.W., Lee, Z.W., Kim, D., Ha, K.S., Shin, H.S., Ryu, S.H., Suh, P.G. Mol. Cells (2005) [Pubmed]
  2. Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Mende, U., Kagen, A., Cohen, A., Aramburu, J., Schoen, F.J., Neer, E.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  3. Nuclear phospholipase C beta1 (PLCbeta1) affects CD24 expression in murine erythroleukemia cells. Fiume, R., Faenza, I., Matteucci, A., Astolfi, A., Vitale, M., Martelli, A.M., Cocco, L. J. Biol. Chem. (2005) [Pubmed]
  4. Signalling through phospholipase C beta 4 is not essential for midbrain dopaminergic neuron survival. Smits, S.M., van der Nobelen, S., Hornman, K.J., von Oerthel, L., Burbach, J.P., Smidt, M.P. Neuroscience (2005) [Pubmed]
  5. Reduced phospholipase C-beta activity and isoform expression in the cerebellum of TS65Dn mouse: a model of Down syndrome. Ruiz de Azúa, I., Lumbreras, M.A., Zalduegui, A., Baamonde, C., Dierssen, M., Flórez, J., Sallés, J. J. Neurosci. Res. (2001) [Pubmed]
  6. Genetic dissection of theta rhythm heterogeneity in mice. Shin, J., Kim, D., Bianchi, R., Wong, R.K., Shin, H.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Kim, D., Jun, K.S., Lee, S.B., Kang, N.G., Min, D.S., Kim, Y.H., Ryu, S.H., Suh, P.G., Shin, H.S. Nature (1997) [Pubmed]
  8. PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. Hannan, A.J., Blakemore, C., Katsnelson, A., Vitalis, T., Huber, K.M., Bear, M., Roder, J., Kim, D., Shin, H.S., Kind, P.C. Nat. Neurosci. (2001) [Pubmed]
  9. Phosphoinositide signaling in nuclei of Friend cells: tiazofurin down-regulates phospholipase C beta 1. Manzoli, L., Billi, A.M., Gilmour, R.S., Martelli, A.M., Matteucci, A., Rubbini, S., Weber, G., Cocco, L. Cancer Res. (1995) [Pubmed]
  10. Inositides in the nucleus: further developments on phospholipase C beta 1 signalling during erythroid differentiation and IGF-I induced mitogenesis. Cocco, L., Capitani, S., Barnabei, O., Gilmour, R.S., Rhee, S.G., Manzoli, F.A. Adv. Enzyme Regul. (1999) [Pubmed]
  11. Cytoplasmic and nuclear phospholipase C-beta 1 relocation: role in resumption of meiosis in the mouse oocyte. Avazeri, N., Courtot, A.M., Pesty, A., Duquenne, C., Lefèvre, B. Mol. Biol. Cell (2000) [Pubmed]
  12. Phospholipase C-beta1 directly accelerates GTP hydrolysis by Galphaq and acceleration is inhibited by Gbeta gamma subunits. Chidiac, P., Ross, E.M. J. Biol. Chem. (1999) [Pubmed]
  13. Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts. Godwin, S.L., Soltoff, S.P. Bone (2002) [Pubmed]
  14. The intranuclear amount of phospholipase C beta 1 decreases following cell differentiation in Friend cells, whereas gamma 1 isoform is not affected. Zini, N., Ognibene, A., Marmiroli, S., Bavelloni, A., Maltarello, M.C., Faenza, I., Valmori, A., Maraldi, N.M. Eur. J. Cell Biol. (1995) [Pubmed]
  15. Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signalling. Spires, T.L., Molnár, Z., Kind, P.C., Cordery, P.M., Upton, A.L., Blakemore, C., Hannan, A.J. Cereb. Cortex (2005) [Pubmed]
  16. Trophoblast adhesion of the peri-implantation mouse blastocyst is regulated by integrin signaling that targets phospholipase C. Wang, J., Mayernik, L., Armant, D.R. Dev. Biol. (2007) [Pubmed]
  17. Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. Walensky, L.D., Snyder, S.H. J. Cell Biol. (1995) [Pubmed]
  18. Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2. LaMorte, V.J., Harootunian, A.T., Spiegel, A.M., Tsien, R.Y., Feramisco, J.R. J. Cell Biol. (1993) [Pubmed]
  19. Nuclear but not cytoplasmic phospholipase C beta 1 inhibits differentiation of erythroleukemia cells. Matteucci, A., Faenza, I., Gilmour, R.S., Manzoli, L., Billi, A.M., Peruzzi, D., Bavelloni, A., Rhee, S.G., Cocco, L. Cancer Res. (1998) [Pubmed]
  20. Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. Liu, F., Virshup, D.M., Nairn, A.C., Greengard, P. J. Biol. Chem. (2002) [Pubmed]
  21. Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. Lee, A.C., Wong, R.K., Chuang, S.C., Shin, H.S., Bianchi, R. J. Neurophysiol. (2002) [Pubmed]
  22. Potentiation by cholera toxin of bradykinin-induced inositol phosphate production in the osteoblast-like cell line MC3T3-E1. Banno, Y., Sakai, T., Kumada, T., Nozawa, Y. Biochem. J. (1993) [Pubmed]
  23. Keratinocyte differentiation is associated with changes in the expression and regulation of phospholipase C isoenzymes. Punnonen, K., Denning, M., Lee, E., Li, L., Rhee, S.G., Yuspa, S.H. J. Invest. Dermatol. (1993) [Pubmed]
  24. delta Opioid receptor subtypes activate inositol-signaling pathways in the production of antinociception. Sánchez-Blázquez, P., Garzón, J. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  25. Disruption of the mouse phospholipase C-beta1 gene in a beta-lactoglobulin transgenic line affects viability, growth, and fertility in mice. Ballester, M., Molist, J., Lopez-Bejar, M., Sánchez, A., Santaló, J., Folch, J.M., Ibáñez, E. Gene (2004) [Pubmed]
  26. The germinal vesicle of the mouse oocyte contains elements of the phosphoinositide cycle: what is their role at meiosis resumption? Avazeri, N., Pesty, A., Lefèvre, B. Reprod. Nutr. Dev. (1998) [Pubmed]
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