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Chemical Compound Review

SODIUM CHOLATE     sodium(4R)-4-[ (3R,5S,7R,8S,9S,10S,12S,13R...

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Disease relevance of cholate


High impact information on cholate


Chemical compound and disease context of cholate


Biological context of cholate


Anatomical context of cholate


Associations of cholate with other chemical compounds


Gene context of cholate

  • Lecithin:cholesterol acyltransferase analysis, using reconstituted HDL particles prepared by the sodium cholate dialysis method, has shown that mutants (Pro165-->Ala,Gln172-->Glu) (Leu211-->Val,Leu214-->Val, Leu218-->Val,Leu219-->Val), Leu222-->Lys,Phe225-->Lys, Phe229-->Lys) and delta209-243 reduced LCAT activation (38-68%) [29].
  • We further demonstrate that feeding mice with diets containing cholestyramine or sodium cholate increases mRNA-expression of ES-x in liver 2.5- to 3-fold [30].
  • PLA2 activities in tissues and sera were quantitated by phosphatidyl-glycerol/sodium cholate mixed micelle assay [31].
  • This study shows that sodium cholate is not necessary for the formation of atherosclerosis in LDLR(-/-) mice and that precisely defined semipurified diets are a valuable tool for the examination of diet-gene interactions [32].
  • Artificial heterodimeric sigma 1, capable of NADPH oxidase activation, could be reconstituted in vitro by recombining purified monomeric rac1 p21 and rho GDI and removing the sodium cholate used to dissociate the native sigma 1 dimer [33].

Analytical, diagnostic and therapeutic context of cholate

  • The purification method includes an aqueous two-phase separation technique, a treatment of the crude factor with sodium cholate and two successive column chromatographies on diethyl-aminoethyl-Sephadex A-50 [34].
  • Activity of 7-alpha-Dehydroxylase was detected within a pH range of 5 to 9 and was 8-fold higher in specific activity in cell cultures in the presence of 0.1 mM sodium cholate than in its absence [35].
  • Micellar electrokinetic chromatography (MEKC) with one kind of bile salt (sodium cholate) was used to separate three chiral polychlorinated biphenyls (PCBs; 84, 95, and 176), each one in its two enantiomers [36].
  • The 400 MHz 1H-nuclear magnetic resonance spectrum of sodium cholate in dilute aqueous solution has been successfully resolved using a combination of decoupling, partial relaxation, and decoupled partial relaxation techniques [37].
  • ApoE*3 Leiden mice developed marked hypercholesterolaemia, and early Type I 'fatty streak' lesions, following consumption of an atherogenic diet high in saturated fat and cholesterol, and containing sodium cholate, for up to 4 weeks [38].


  1. Sterilisation of hepatitis and HTLV-III viruses by exposure to tri(n-butyl)phosphate and sodium cholate. Prince, A.M., Horowitz, B., Brotman, B. Lancet (1986) [Pubmed]
  2. Reconstitution of protein translocation from detergent-solubilized Escherichia coli inverted vesicles: PrlA protein-deficient vesicles efficiently translocate precursor proteins. Watanabe, M., Nicchitta, C.V., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  3. Resolution and reconstitution of active transport of calcium by a protein(s) from Mycobacterium phlei. Lee, S.H., Kalra, V.K., Brodie, A.F. J. Biol. Chem. (1979) [Pubmed]
  4. Enzymic differentiation of neurologic and nonneurologic forms of Gaucher's disease. Glew, R.H., Daniels, L.B., Clark, L.S., Hoyer, S.W. J. Neuropathol. Exp. Neurol. (1982) [Pubmed]
  5. Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes. Nicchitta, C.V., Blobel, G. Cell (1990) [Pubmed]
  6. Expression in Xenopus oocytes of rat liver mRNA coding for a bile salt-dependent cholesteryl ester hydrolase. Zolfaghari, R., Harrison, E.H., Ross, A.C., Fisher, E.A. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  7. Identification of the binding subunit of the sigma-type opiate receptor by photoaffinity labeling with 1-(4-azido-2-methyl[6-3H]phenyl)-3-(2-methyl[4,6-3H]phenyl)guanidine. Kavanaugh, M.P., Tester, B.C., Scherz, M.W., Keana, J.F., Weber, E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  8. Intramural hemorrhage and endothelial changes in atherosclerotic coronary artery after repetitive episodes of spasm in x-ray-irradiated hypercholesterolemic pigs. Nagasawa, K., Tomoike, H., Hayashi, Y., Yamada, A., Yamamoto, T., Nakamura, M. Circ. Res. (1989) [Pubmed]
  9. Solubilization of the apamin receptor associated with a calcium-activated potassium channel from rat brain. Seagar, M.J., Marqueze, B., Couraud, F. J. Neurosci. (1987) [Pubmed]
  10. Repair of DNA Damage Induced by Bile Salts in Salmonella enterica. Prieto, A.I., Ramos-Morales, F., Casades??s, J. Genetics (2006) [Pubmed]
  11. A multistep procedure for the chemical inactivation of human immunodeficiency virus for use as an experimental vaccine. Race, E., Stein, C.A., Wigg, M.D., Baksh, A., Addawe, M., Frezza, P., Oxford, J.S. Vaccine (1995) [Pubmed]
  12. Growth, sporulation and enterotoxin production by Clostridium perfringens type A in the presence of human bile salts. Heredia, N.L., Labbe, R.G., Rodriguez, M.A., Garcia-Alvarado, J.S. FEMS Microbiol. Lett. (1991) [Pubmed]
  13. Rapid-onset intranasal delivery of metoclopramide hydrochloride Part II: Safety of various absorption enhancers and pharmacokinetic evaluation. Zaki, N.M., Mortada, N.D., Awad, G.A., Elhady, S.S. International journal of pharmaceutics (2006) [Pubmed]
  14. Mild hepatic fibrosis in cholesterol and sodium cholate diet-fed rats. Jeong, W.I., Jeong, D.H., Do, S.H., Kim, Y.K., Park, H.Y., Kwon, O.D., Kim, T.H., Jeong, K.S. J. Vet. Med. Sci. (2005) [Pubmed]
  15. Molecular characterization, reconstitution, and "transport-specific fractionation" of the saxitoxin binding protein/Na+ gate of mammalian brain. Goldin, S.M., Rhoden, V., Hess, E.J. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  16. Isolation and characterization of ceramide glycanase from the leech, Macrobdella decora. Zhou, B., Li, S.C., Laine, R.A., Huang, R.T., Li, Y.T. J. Biol. Chem. (1989) [Pubmed]
  17. Solubilization and reassembly of the mitochondrial benzodiazepine receptor. Anholt, R.R., Aebi, U., Pedersen, P.L., Snyder, S.H. Biochemistry (1986) [Pubmed]
  18. Characterization of the recombination reaction of rhodopsin. Henselman, R.A., Cusanovich, M.A. Biochemistry (1976) [Pubmed]
  19. In vitro activity of CI-934, a quinolone carboxylic acid active against gram-positive and -negative bacteria. Cohen, M.A., Griffin, T.J., Bien, P.A., Heifetz, C.L., Domagala, J.M. Antimicrob. Agents Chemother. (1985) [Pubmed]
  20. Specific binding of perhydrohistrionicotoxin to Torpedo acetylcholine receptor. Elliott, J., Dunn, S.M., Blanchard, S.G., Raftery, M.A. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  21. Preparation and properties of partially purified pulmonary cytochrome P-450 from rabbits. Arinç, E., Philpot, M. J. Biol. Chem. (1976) [Pubmed]
  22. Purification of a 3beta-hydroxy-delta5-C27-steroid dehydrogenase from pig liver microsomes active in major and alternative pathways of bile acid biosynthesis. Furster, C., Zhang, J., Toll, A. J. Biol. Chem. (1996) [Pubmed]
  23. A receptor and G-protein-regulated polyphosphoinositide-specific phospholipase C from turkey erythrocytes. I. Purification and properties. Morris, A.J., Waldo, G.L., Downes, C.P., Harden, T.K. J. Biol. Chem. (1990) [Pubmed]
  24. Kinetics and thermodynamics of dissolution of lecithin by bile salts. Lindenbaum, S., Rajagopalan, N. Hepatology (1984) [Pubmed]
  25. Phospholipid requirement for expression of ice nuclei in Pseudomonas syringae and in vitro. Govindarajan, A.G., Lindow, S.E. J. Biol. Chem. (1988) [Pubmed]
  26. Purification and characterization of phosphatidate phosphatase from Saccharomyces cerevisiae. Lin, Y.P., Carman, G.M. J. Biol. Chem. (1989) [Pubmed]
  27. Synthesis of neoglycoconjugates using oligosaccharide transferring activity of ceramide glycanase. Li, Y.T., Carter, B.Z., Rao, B.N., Schweingruber, H., Li, S.C. J. Biol. Chem. (1991) [Pubmed]
  28. Side chain hydroxylations in biosynthesis of cholic acid. 25- and 26-Hydroxylation of 5beta-cholestane-3alpha, 7alpha, 12alpha-triol by reconstituted systems from rat liver microsomes. Björkhem, I., Danielsson, H., Wikvall, K. J. Biol. Chem. (1976) [Pubmed]
  29. The carboxyl-terminal hydrophobic residues of apolipoprotein A-I affect its rate of phospholipid binding and its association with high density lipoprotein. Laccotripe, M., Makrides, S.C., Jonas, A., Zannis, V.I. J. Biol. Chem. (1997) [Pubmed]
  30. Cloning and sequencing of a novel murine liver carboxylesterase cDNA. Ellinghaus, P., Seedorf, U., Assmann, G. Biochim. Biophys. Acta (1998) [Pubmed]
  31. Group IIA phospholipase A2 mediates lung injury in intestinal ischemia-reperfusion. Koike, K., Yamamoto, Y., Hori, Y., Ono, T. Ann. Surg. (2000) [Pubmed]
  32. Hyperlipidemia and atherosclerotic lesion development in LDL receptor-deficient mice fed defined semipurified diets with and without cholate. Lichtman, A.H., Clinton, S.K., Iiyama, K., Connelly, P.W., Libby, P., Cybulsky, M.I. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  33. Role of the rac1 p21-GDP-dissociation inhibitor for rho heterodimer in the activation of the superoxide-forming NADPH oxidase of macrophages. Pick, E., Gorzalczany, Y., Engel, S. Eur. J. Biochem. (1993) [Pubmed]
  34. Purification and properties of a new polypeptide chain elongation factor, EF-1beta, from pig liver. Iwasaki, K., Motoyoshi, K., Nagata, S., Kaziro, Y. J. Biol. Chem. (1976) [Pubmed]
  35. Characterization of 7-alpha-dehydroxylase in Clostridium leptum. Stellwag, E.J., Hylemon, P.B. Am. J. Clin. Nutr. (1978) [Pubmed]
  36. Chiral separation of polychlorinated biphenyls by micellar electrokinetic chromatography with sodium cholate. Crego, A.L., Gonzalez, M.J., Marina, M.L. Electrophoresis (1998) [Pubmed]
  37. High resolution nuclear magnetic resonance spectroscopy of bile salts: individual proton assignments for sodium cholate in aqueous solution at 400 MHz. Barnes, S., Geckle, J.M. J. Lipid Res. (1982) [Pubmed]
  38. Hypercholesterolaemia and circulating levels of CXC chemokines in apoE*3 Leiden mice. Murphy, N., Grimsditch, D.C., Parkin, S., Vidgeon-Hart, M.P., Overend, P., Groot, P.H., Graham, A., Benson, G.M. Atherosclerosis (2002) [Pubmed]
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