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Gene Review:

IFNA8 - interferon, alpha 8

Homo sapiens

Synonyms: IFN-alpha-8, IFN-alphaB, Interferon alpha-8, Interferon alpha-B, Interferon alpha-B2, ...

Frissen, P.H. et al., Yelverton, E. et al., Wintergerst, U. et al., Gangemi, J.D. et al., Bayley, D. et al., et al.

Morrey, Korba, Sidwell,

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Disease relevance of IFNA8

Significant differences in therapeutic responses to a human interferon-alpha B/D hybrid in Rauscher or Friend murine leukemia virus infections [1].
Tolerability and activity of a new recombinant interferon-alpha B/D hybrid in patients with HIV-1 infection [2].
The maximum tolerated dose (MTD) and toxicity profile of a new recombinant interferon-alpha B/D hybrid (IFN-alpha B/D) in HlV-1-infected patients were determined in an outpatient, dose-escalating study with dose groups of three patients: 16, 32, 48, 64, 96 and 112 million international units (MIU) three times weekly subcutaneously during 12 weeks [2].
Tolerance and antiviral effects of high-dose interferon-alpha B/D in patients with chronic hepatitis B [3].
The efficacy of recombinant human interferon alpha B/D in experimental HSV-1 encephalitis was investigated in the murine system [4].

High impact information on IFNA8

Evaluation of lamivudine, zidovudine and interferon-alpha B/D (IFN-alpha) in this HBV transgenic mouse model are described [5].
Direct antiproliferative effects of recombinant human interferon-alpha B/D hybrids on human tumor cell lines [6].
LeIF B exhibits markedly different specificities from another bacterially synthesized human leukocyte interferon, LeIF A [7].
The nucleotide sequence of LeIF B differs significantly from other published leukocyte interferon cDNA sequences [7].
A novel human leukocyte interferon cDNA clone (LeIF B) was identified in a cDNA library prepared using polyadenylated mRNA of a myeloblastoid cell line [7].

Chemical compound and disease context of IFNA8

Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis [4].

Biological context of IFNA8

The polymerase chain reaction (PCR) was used to introduce a phosphorylation site into human interferon-alpha B2 (Hu-IFN-alpha B2) and the chimeric human interferon-alpha A/D (Hu-IFN-alpha A/D) [8].
Possible sites of administration include the various regions of the gastrointestinal tract and airways, and this paper reports the bioavailability of interferon-alpha B/D via these routes in the rat and rabbit [9].

Anatomical context of IFNA8

The antiviral potential of a novel cross-species active, recombinant human interferon-alpha B/D hybrid (rHuIFN-alpha B/D), was evaluated for its efficiacy in cultured human monocytes and in several murine models of viral disease [10].

References

Significant differences in therapeutic responses to a human interferon-alpha B/D hybrid in Rauscher or Friend murine leukemia virus infections. Gangemi, J.D., Matter, A., Poncioni, B., Hochkeppel, H.K. J. Interferon Res. (1989) [Pubmed]
Tolerability and activity of a new recombinant interferon-alpha B/D hybrid in patients with HIV-1 infection. Frissen, P.H., Brinkman, K., Ten Napel, C.H., van der Ende, I.M., van Buuren, I.A., Boucher, C.A., Reiss, P., Lange, J.M. Antivir. Ther. (Lond.) (1996) [Pubmed]
Tolerance and antiviral effects of high-dose interferon-alpha B/D in patients with chronic hepatitis B. Rasch, M.C., Schellekens, H., van Dijck, C.M., Haagsma, E.B., Michielsen, P.P., van Buuren, A.H., Stötter, H., van Hattum, J. Dig. Dis. Sci. (1998) [Pubmed]
Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis. Wintergerst, U., Gangemi, J.D., Whitley, R.J., Chatterjee, S., Kern, E.R. Antiviral Res. (1999) [Pubmed]
Transgenic mice as a chemotherapeutic model for hepatitis B virus infection. Morrey, J.D., Korba, B.E., Sidwell, R.W. Antivir. Ther. (Lond.) (1998) [Pubmed]
Direct antiproliferative effects of recombinant human interferon-alpha B/D hybrids on human tumor cell lines. Fidler, I.J., Heicappell, R., Saiki, I., Grutter, M.G., Horisberger, M.A., Nuesch, J. Cancer Res. (1987) [Pubmed]
Bacterial synthesis of a novel human leukocyte interferon. Yelverton, E., Leung, D., Weck, P., Gray, P.W., Goeddel, D.V. Nucleic Acids Res. (1981) [Pubmed]
Construction and activity of phosphorylatable human interferon-alpha B2 and interferon-alpha A/D. Wang, P., Izotova, L., Mariano, T.M., Donnelly, R.J., Pestka, S. J. Interferon Res. (1994) [Pubmed]
The transmucosal absorption of recombinant human interferon-alpha B/D hybrid in the rat and rabbit. Bayley, D., Temple, C., Clay, V., Steward, A., Lowther, N. J. Pharm. Pharmacol. (1995) [Pubmed]
Antiviral activity of a novel recombinant human interferon-alpha B/D hybrid. Gangemi, J.D., Lazdins, J., Dietrich, F.M., Matter, A., Poncioni, B., Hochkeppel, H.K. J. Interferon Res. (1989) [Pubmed]

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