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Gene Review

IFNA8  -  interferon, alpha 8

Homo sapiens

Synonyms: IFN-alpha-8, IFN-alphaB, Interferon alpha-8, Interferon alpha-B, Interferon alpha-B2, ...
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Disease relevance of IFNA8


High impact information on IFNA8


Chemical compound and disease context of IFNA8


Biological context of IFNA8


Anatomical context of IFNA8

  • The antiviral potential of a novel cross-species active, recombinant human interferon-alpha B/D hybrid (rHuIFN-alpha B/D), was evaluated for its efficiacy in cultured human monocytes and in several murine models of viral disease [10].


  1. Significant differences in therapeutic responses to a human interferon-alpha B/D hybrid in Rauscher or Friend murine leukemia virus infections. Gangemi, J.D., Matter, A., Poncioni, B., Hochkeppel, H.K. J. Interferon Res. (1989) [Pubmed]
  2. Tolerability and activity of a new recombinant interferon-alpha B/D hybrid in patients with HIV-1 infection. Frissen, P.H., Brinkman, K., Ten Napel, C.H., van der Ende, I.M., van Buuren, I.A., Boucher, C.A., Reiss, P., Lange, J.M. Antivir. Ther. (Lond.) (1996) [Pubmed]
  3. Tolerance and antiviral effects of high-dose interferon-alpha B/D in patients with chronic hepatitis B. Rasch, M.C., Schellekens, H., van Dijck, C.M., Haagsma, E.B., Michielsen, P.P., van Buuren, A.H., Stötter, H., van Hattum, J. Dig. Dis. Sci. (1998) [Pubmed]
  4. Effect of recombinant human interferon alpha B/D (rHu-IFN-alpha B/D) in combination with acyclovir in experimental HSV-1 encephalitis. Wintergerst, U., Gangemi, J.D., Whitley, R.J., Chatterjee, S., Kern, E.R. Antiviral Res. (1999) [Pubmed]
  5. Transgenic mice as a chemotherapeutic model for hepatitis B virus infection. Morrey, J.D., Korba, B.E., Sidwell, R.W. Antivir. Ther. (Lond.) (1998) [Pubmed]
  6. Direct antiproliferative effects of recombinant human interferon-alpha B/D hybrids on human tumor cell lines. Fidler, I.J., Heicappell, R., Saiki, I., Grutter, M.G., Horisberger, M.A., Nuesch, J. Cancer Res. (1987) [Pubmed]
  7. Bacterial synthesis of a novel human leukocyte interferon. Yelverton, E., Leung, D., Weck, P., Gray, P.W., Goeddel, D.V. Nucleic Acids Res. (1981) [Pubmed]
  8. Construction and activity of phosphorylatable human interferon-alpha B2 and interferon-alpha A/D. Wang, P., Izotova, L., Mariano, T.M., Donnelly, R.J., Pestka, S. J. Interferon Res. (1994) [Pubmed]
  9. The transmucosal absorption of recombinant human interferon-alpha B/D hybrid in the rat and rabbit. Bayley, D., Temple, C., Clay, V., Steward, A., Lowther, N. J. Pharm. Pharmacol. (1995) [Pubmed]
  10. Antiviral activity of a novel recombinant human interferon-alpha B/D hybrid. Gangemi, J.D., Lazdins, J., Dietrich, F.M., Matter, A., Poncioni, B., Hochkeppel, H.K. J. Interferon Res. (1989) [Pubmed]
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