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Gene Review

IFNA2  -  interferon, alpha 2

Homo sapiens

Synonyms: IFN-alpha-2, IFN-alphaA, IFNA, IFNA2A, IFNA2B, ...
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Disease relevance of IFNA2


Psychiatry related information on IFNA2


High impact information on IFNA2


Chemical compound and disease context of IFNA2


Biological context of IFNA2


Anatomical context of IFNA2


Associations of IFNA2 with chemical compounds

  • Focusing on the molecular mechanism underlying the dominant negative effect of IRF-7 DN, we found that virus-activated transcription of endogenous IFNA genes requires full-length IRF-7 and that Serine 483 and 484 play an essential role [22].
  • The anti-Friend leukemia virus (FLV) effects of interferon-alpha-A/D (IFN-alpha) and 2',3'-didehydro-2',3'-dideoxythymidine (stavudine) used alone and in combination were examined in Mus dunni cells using a checkerboard-type experiment design [23].
  • The effect of IFNA on C4 was inconclusive but indicates an effect during the initial phase of the treatment [21].
  • Localization of 2',5'-oligoadenylate synthetase and the enhancement of its activity with recombinant interferon-alpha A/D in the mouse brain [24].
  • IFNA induced a significant increase in the concentration of C1 inhibitor (INH) [21].

Physical interactions of IFNA2

  • Iodinated human interferon alpha A (HuIFN-alpha A) was found to bind specifically to IFN-sensitive RSa cells: the dissociation constant was 8.7 X 10(-10)M and the estimated number of receptor sites per cell was 1110 [25].

Regulatory relationships of IFNA2


Other interactions of IFNA2


Analytical, diagnostic and therapeutic context of IFNA2


  1. Correlation between interferon (IFN) alpha resistance and deletion of the IFN alpha/beta genes in acute leukemia cell lines suggests selection against the IFN system. Colamonici, O.R., Domanski, P., Platanias, L.C., Diaz, M.O. Blood (1992) [Pubmed]
  2. Human interferon alpha A or alpha D and trifluridine treatment for herpetic keratitis in rabbits. Trousdale, M.D., Nesburn, A.B. Invest. Ophthalmol. Vis. Sci. (1984) [Pubmed]
  3. Diversity in inhibitory effects of IFN-gamma and IFN-alpha A on the induced DNA synthesis of a hairy cell leukemia B lymphocyte clone reflects the nature of the activating ligand. Mongini, P., Seremetis, S., Blessinger, C., Rudich, S., Winchester, R., Brunda, M. Blood (1988) [Pubmed]
  4. Inhibition of intravascular mouse melanoma dissemination by recombinant human interferon alpha A/D. Yokoyama, T., Yoshie, O., Aso, H., Ebina, T., Ishida, N. Jpn. J. Cancer Res. (1986) [Pubmed]
  5. A rare form of narcolepsy (HLA-DR2-) shows possible association with (functionally relevant) alpha-interferon gene polymorphisms. Wieczorek, S., Dahmen, N., Kasten, M., Epplen, J.T., Gencik, M. Psychiatr. Genet. (2004) [Pubmed]
  6. Hematologic remission and cytogenetic improvement induced by recombinant human interferon alpha A in chronic myelogenous leukemia. Talpaz, M., Kantarjian, H.M., McCredie, K., Trujillo, J.M., Keating, M.J., Gutterman, J.U. N. Engl. J. Med. (1986) [Pubmed]
  7. Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Cannon-Albright, L.A., Goldgar, D.E., Meyer, L.J., Lewis, C.M., Anderson, D.E., Fountain, J.W., Hegi, M.E., Wiseman, R.W., Petty, E.M., Bale, A.E. Science (1992) [Pubmed]
  8. Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers. Kishimoto, Y., Sugio, K., Hung, J.Y., Virmani, A.K., McIntire, D.D., Minna, J.D., Gazdar, A.F. J. Natl. Cancer Inst. (1995) [Pubmed]
  9. Prospects for the prevention and therapy of infections with the human immunodeficiency virus. Vogt, M., Hirsch, M.S. Rev. Infect. Dis. (1986) [Pubmed]
  10. Inhibition of theophylline metabolism by interferon. Williams, S.J., Baird-Lambert, J.A., Farrell, G.C. Lancet (1987) [Pubmed]
  11. Three-drug synergistic inhibition of HIV-1 replication in vitro by zidovudine, recombinant soluble CD4, and recombinant interferon-alpha A. Johnson, V.A., Barlow, M.A., Merrill, D.P., Chou, T.C., Hirsch, M.S. J. Infect. Dis. (1990) [Pubmed]
  12. Synergistic interaction of 2',3'-dideoxycytidine and recombinant interferon-alpha-A on replication of human immunodeficiency virus type 1. Vogt, M.W., Durno, A.G., Chou, T.C., Coleman, L.A., Paradis, T.J., Schooley, R.T., Kaplan, J.C., Hirsch, M.S. J. Infect. Dis. (1988) [Pubmed]
  13. Two-drug combinations of zidovudine, didanosine, and recombinant interferon-alpha A inhibit replication of zidovudine-resistant human immunodeficiency virus type 1 synergistically in vitro. Johnson, V.A., Merrill, D.P., Videler, J.A., Chou, T.C., Byington, R.E., Eron, J.J., D'Aquila, R.T., Hirsch, M.S. J. Infect. Dis. (1991) [Pubmed]
  14. Polymorphism in the interferon-alpha gene family. Golovleva, I., Kandefer-Szerszen, M., Beckman, L., Lundgren, E. Am. J. Hum. Genet. (1996) [Pubmed]
  15. DNA sequence of a major human leukocyte interferon gene. Lawn, R.M., Gross, M., Houck, C.M., Franke, A.E., Gray, P.V., Goeddel, D.V. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  16. Effect of recombinant human interferon-alpha A/D on in vivo murine tumor cell growth. Uno, K., Shimizu, S., Inaba, K., Kitaura, M., Nakahira, K., Kato, T., Yamaguchi, Y., Muramatsu, S. Cancer Res. (1988) [Pubmed]
  17. Creation of phosphorylation sites in proteins: construction of a phosphorylatable human interferon alpha. Li, B.L., Langer, J.A., Schwartz, B., Pestka, S. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  18. Transcription of interferon-alpha 2 alleles from virus-induced human leucocytes and lymphoblastoid cells of African origin. Linge, C., Gewert, D., Ellis, J., Tucker, D., Allen, G., Crowe, J.S. Biochim. Biophys. Acta (1995) [Pubmed]
  19. Characterization of the interferon regulatory factor-7 and its potential role in the transcription activation of interferon A genes. Au, W.C., Moore, P.A., LaFleur, D.W., Tombal, B., Pitha, P.M. J. Biol. Chem. (1998) [Pubmed]
  20. Potentiation of antitumor activity of macrophages by recombinant interferon alpha A/D contained in gelatin microspheres. Tabata, Y., Uno, K., Ikada, Y., Muramatsu, S. Jpn. J. Cancer Res. (1988) [Pubmed]
  21. The effects of interferon-alpha2a on concentrations of immunoglobulins, complement and lymphocytes in patients with multiple sclerosis. Ulvestad, E., Aarseth, J.H., Vedeler, C., Nyland, H., Myhr, K.M. Scand. J. Immunol. (2004) [Pubmed]
  22. Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3. Au, W.C., Yeow, W.S., Pitha, P.M. Virology (2001) [Pubmed]
  23. Effect of the combination of interferon-alpha and stavudine on Friend virus infections in (B10.A x A.By)F1 mice. Sidwell, R.W., Warren, R.P., Okleberry, K., Burger, R.A., Morrey, J.D. J. Infect. Dis. (1995) [Pubmed]
  24. Localization of 2',5'-oligoadenylate synthetase and the enhancement of its activity with recombinant interferon-alpha A/D in the mouse brain. Asada-Kubota, M., Ueda, T., Nakashima, T., Kobayashi, M., Shimada, M., Takeda, K., Hamada, K., Maekawa, S., Sokawa, Y. Anat. Embryol. (1997) [Pubmed]
  25. Binding of 125I-labeled human interferon to cell lines with low sensitivity to interferon. Fuse, A., Ashino-Fuse, H., Kuwata, T. Gann = Gan. (1984) [Pubmed]
  26. Interferon-alpha prevents endotoxin-induced mortality in mice. Tzung, S.P., Mahl, T.C., Lance, P., Andersen, V., Cohen, S.A. Eur. J. Immunol. (1992) [Pubmed]
  27. Novel variants of human IFN-alpha detected in tumor cell lines and biopsy specimens. Golovleva, I., Biasotto, M., Verpy, E., Roos, G., Meo, T., Tosi, M., Lundgren, E. J. Interferon Cytokine Res. (1997) [Pubmed]
  28. Bacterial synthesis of a novel human leukocyte interferon. Yelverton, E., Leung, D., Weck, P., Gray, P.W., Goeddel, D.V. Nucleic Acids Res. (1981) [Pubmed]
  29. A functional protein kinase C is required for induction of 2-5A synthetase by recombinant interferon-alpha A in Daudi cells. Faltynek, C.R., Princler, G.L., Gusella, G.L., Varesio, L., Radzioch, D. J. Biol. Chem. (1989) [Pubmed]
  30. Opposite effects of recombinant interferon-alpha A and deoxycoformycin on adenosine deaminase activity in the Daudi B lymphoblastoid cell line. Faltynek, C.R. Blood (1988) [Pubmed]
  31. Antiviral effects of highly purified bacteria-derived human leukocyte interferons (subtypes A and D) and a human fibroblast interferon against herpes virus infection of the rabbit eye. Grabner, G., Smolin, G., Okumoto, M., Stebbing, N. Curr. Eye Res. (1982) [Pubmed]
  32. Induction of cytokine production by different Staphylococcal strains. Megyeri, K., Mándi, Y., Degré, M., Rosztóczy, I. Cytokine (2002) [Pubmed]
  33. Construction and activity of phosphorylatable human interferon-alpha B2 and interferon-alpha A/D. Wang, P., Izotova, L., Mariano, T.M., Donnelly, R.J., Pestka, S. J. Interferon Res. (1994) [Pubmed]
  34. Involvement of LEU13 in interferon-induced refractoriness of human RSa cells to cell killing by X rays. Kita, K., Sugaya, S., Zhai, L., Wu, Y.P., Wano, C., Chigira, S., Nomura, J., Takahashi, S., Ichinose, M., Suzuki, N. Radiat. Res. (2003) [Pubmed]
  35. Molecular deletion of 9p sequences in non-small cell lung cancer and malignant mesothelioma. Center, R., Lukeis, R., Dietzsch, E., Gillespie, M., Garson, O.M. Genes Chromosomes Cancer (1993) [Pubmed]
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