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IMPG1  -  interphotoreceptor matrix proteoglycan 1

Homo sapiens

Synonyms: GP147, IPM-150, IPM150, Interphotoreceptor matrix proteoglycan 1, Interphotoreceptor matrix proteoglycan of 150 kDa, ...
 
 
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Disease relevance of IMPG1

 

High impact information on IMPG1

  • SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan [3].
  • SPACR (sialoprotein associated with cones and rods), is the major 147-150-kDa glycoprotein present in the insoluble interphotoreceptor matrix of the human retina [3].
  • SPACR is not a chondroitin sulfate proteoglycan, since it is not a product of chondroitinase ABC digestion and does not react to a specific antibody for chondroitin 6-sulfate proteoglycan [3].
  • In addition, using an intragenic polymorphism, IMPG1 was excluded by genetic recombination from both the PBCRA and the MCDR1 loci [4].
  • However, as the autosomal dominant Stargardt-like macular dystrophies are genetically heterogeneous, other forms of this disorder, in particular STGD3 previously linked to 6q, may be caused by mutations in IMPG1 [4].
 

Biological context of IMPG1

 

Anatomical context of IMPG1

 

Associations of IMPG1 with chemical compounds

 

Other interactions of IMPG1

  • CONCLUSIONS: Analysis of the overall relationship of human IMPG2 (located on chromosome 3q12.2-12.3) to human IMPG1 (located on chromosome 6q14) suggests that these genes have evolved from a common ancestral gene [11].
  • Two candidate genes, EEF1A1 and IMPG1, were selected from the region between D6S280 and D6S1644 markers where the families are linked [6].
  • Maackia amurensis agglutinins (MAA-1 and MAA-2), specific for sialic acid in alpha2-3 linkage to Gal, bind SPACR, while Sambucus nigra agglutinin (SNA), specific for alpha2-6 linked sialic acid, does not, indicating that the dominant glycoconjugate determinant on SPACR is the O-linked carbohydrate, NeuAcalpha2-3Galbeta1-3GalNAc [10].
  • 3. Based on homologies within their amino acid sequences we propose that IPM 200 and a previously described human proteoglycan, IPM 150, form a new family of extracellular matrix glycoconjugates [12].
 

Analytical, diagnostic and therapeutic context of IMPG1

References

  1. Photoreceptor cell differentiation in retinoblastoma demonstrated by a new immunohistochemical marker mucin-like glycoprotein associated with photoreceptor cells (MLGAPC). Tsuji, M., Goto, M., Uehara, F., Kaneko, A., Sawai, J., Yonezawa, S., Ohba, N. Histopathology (2002) [Pubmed]
  2. Diversity in the arrangement of the CTX prophages in classical strains of Vibrio cholerae O1. Basu, A., Mukhopadhyay, A.K., Garg, P., Chakraborty, S., Ramamurthy, T., Yamasaki, S., Takeda, Y., Nair, G.B. FEMS Microbiol. Lett. (2000) [Pubmed]
  3. SPACR, a novel interphotoreceptor matrix glycoprotein in human retina that interacts with hyaluronan. Acharya, S., Rodriguez, I.R., Moreira, E.F., Midura, R.J., Misono, K., Todres, E., Hollyfield, J.G. J. Biol. Chem. (1998) [Pubmed]
  4. Assessment of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene localised to 6q13-q15 in autosomal dominant Stargardt-like disease (ADSTGD), progressive bifocal chorioretinal atrophy (PBCRA), and North Carolina macular dystrophy (MCDR1). Gehrig, A., Felbor, U., Kelsell, R.E., Hunt, D.M., Maumenee, I.H., Weber, B.H. J. Med. Genet. (1998) [Pubmed]
  5. The benign concentric annular macular dystrophy locus maps to 6p12.3-q16. van Lith-Verhoeven, J.J., Hoyng, C.B., van den Helm, B., Deutman, A.F., Brink, H.M., Kemperman, M.H., de Jong, W.H., Kremer, H., Cremers, F.P. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  6. Molecular genetic analysis of two functional candidate genes in the autosomal recessive retinitis pigmentosa, RP25, locus. Abd El-Aziz, M.M., El-Ashry, M.F., Barragan, I., Marcos, I., Borrego, S., Antiñolo, G., Bhattacharya, S.S. Curr. Eye Res. (2005) [Pubmed]
  7. Gene expression profile of the adult human retinal ganglion cell layer. Kim, C.Y., Kuehn, M.H., Clark, A.F., Kwon, Y.H. Mol. Vis. (2006) [Pubmed]
  8. Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan. Kuehn, M.H., Hageman, G.S. Matrix Biol. (1999) [Pubmed]
  9. Genomic organization and chromosomal localization of the interphotoreceptor matrix proteoglycan-1 (IMPG1) gene: a candidate for 6q-linked retinopathies. Felbor, U., Gehrig, A., Sauer, C.G., Marquardt, A., Köhler, M., Schmid, M., Weber, B.H. Cytogenet. Cell Genet. (1998) [Pubmed]
  10. Characterization of SPACR, a sialoprotein associated with cones and rods present in the interphotoreceptor matrix of the human retina: immunological and lectin binding analysis. Acharya, S., Rayborn, M.E., Hollyfield, J.G. Glycobiology (1998) [Pubmed]
  11. Organization of the human IMPG2 gene and its evaluation as a candidate gene in age-related macular degeneration and other retinal degenerative disorders. Kuehn, M.H., Stone, E.M., Hageman, G.S. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  12. Molecular characterization and genomic mapping of human IPM 200, a second member of a novel family of proteoglycans. Kuehn, M.H., Hageman, G.S. Mol. Cell Biol. Res. Commun. (1999) [Pubmed]
 
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