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Rtcb  -  RNA 2',3'-cyclic phosphate and 5'-OH ligase

Rattus norvegicus

Synonyms: p55, tRNA-splicing ligase RtcB homolog
 
 
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Disease relevance of LOC362855

 

High impact information on LOC362855

  • These results support the existence of at least two different benzodiazepine receptor subtypes associated with proteins P51 and P55 [2].
  • [3H]Ro 15-4513 specifically and irreversibly labeled a protein with an apparent molecular weight of 51,000 (P51) in cerebellum and at least two proteins with apparent molecular weights of 51,000 (P51) and 55,000 (P55) in hippocampus [3].
  • When rat brain membranes were incubated with the benzodiazepine agonist [3H]flunitrazepam or the partial inverse benzodiazepine agonist [3H]Ro 15-4513 in the presence of ultraviolet light one protein (P51) was specifically and irreversibly labeled in cerebellum and at least two proteins (P51 and P55) were labeled in hippocampus [2].
  • These results suggest a close association between reversible and irreversible benzodiazepine binding sites and indicate that membrane-associated proteins P51 and P55 are differentially protected against degradation by trypsin [4].
  • At P55, brain cholesterol was reduced and 7-dehydrocholesterol was increased in all brain regions (p < 0.0001) [5].
 

Biological context of LOC362855

  • Both of these immediate early gene responses were irreversibly lost between P50 and P55 [6].
  • We evaluated the spatial memory in the Morris water maze at P50 approximately 55, the expression of hippocampal cyclic adenosine monophosphate (cAMP)-responsive element-binding protein phosphorylation at serine-133 (pCREBSer-133) at P55, hippocampal neuronal damage at P80 and seizure threshold at P100 [7].
  • The different radiolabeled peptide patterns obtained from P51 or P55, irrespective of the photolabel used, suggest a difference in the molecular structure of these proteins [8].
  • Clopidogrel treatment inhibited the increase in phosphorylation of P140, P100, P80/85, P66 and P55 concomitantly with the inhibition of platelet aggregation [9].
 

Anatomical context of LOC362855

  • [3H]Flunitrazepam reproducibly and irreversibly labeled mainly one protein (P51) in cerebellum and at least two proteins (P51 and P55) in hippocampus at both temperatures [10].
  • When rat brain membranes were incubated with [3H]flunitrazepam in the presence of UV light, predominantly one protein (P51) was irreversibly labeled in cerebellum and at least two proteins (P51 and P55) were labeled in hippocampus [4].
 

Associations of LOC362855 with chemical compounds

  • Experiment 2: Four hundred days after stopping AY-9944 treatment (P420), brain sterol levels had returned to normal levels, but the AY-induced SWD lasted twice as long as at P55 [5].
  • In the capsaicin-treated rats that wore plastic collars, the widest distribution of skin lesions occurred on P55, after which time lesions vanished detection by 25 days [11].
  • Long-term treatment with buspirone for 14 days at a dose (0.5 mg/kg, i.p.) which when applied acutely did not produce any observable effect, caused an increase in the latency of both the N28 and P55 peaks [12].
  • Intrahippocampal (i.h.) injection of 5-hydroxytryptamine (5-HT, 10 micrograms) reduced the amplitude and increased the latency of the N28 and P55 peaks of the HAER [12].
 

Analytical, diagnostic and therapeutic context of LOC362855

  • Proteins P51 and P55 were photolabeled by [3H]flunitrazepam, [3H]clonazepam or 3H-Ro 15-4513 and then compared by peptide mapping after limited digestion with various proteases [8].
  • We also found that P25 ovariectomy enlarged, or defeminized, adult female CC, whereas ovary transfer starting on P55 or P70 counteracted this enlarging effect, resulting in feminized adult CC [13].

References

  1. Expression of the v-mos gene alters a Mr 55,000 protein during acute infection by Moloney murine sarcoma virus. Singh, B., Sparrow, J.T., Hedge, A.M., Arlinghaus, R.B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. Comparison of tryptic peptides of benzodiazepine binding proteins photolabeled with [3H]flunitrazepam or [3H]Ro 15-4513. Sieghart, W., Eichinger, A., Zezula, J. J. Neurochem. (1987) [Pubmed]
  3. Photoaffinity labeling of benzodiazepine receptor proteins with the partial inverse agonist [3H]Ro 15-4513: a biochemical and autoradiographic study. Sieghart, W., Eichinger, A., Richards, J.G., Möhler, H. J. Neurochem. (1987) [Pubmed]
  4. Differential degradation of different benzodiazepine binding proteins by incubation of membranes from cerebellum or hippocampus with trypsin. Eichinger, A., Sieghart, W. J. Neurochem. (1985) [Pubmed]
  5. Brain sterols in the AY-9944 rat model of atypical absence seizures. Cortez, M.A., Cunnane, S.C., Snead, O.C. Epilepsia (2002) [Pubmed]
  6. Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells. Gubits, R.M., Yu, H., Casey, G., Munell, F., Vitek, M.P. J. Neurosci. Res. (1992) [Pubmed]
  7. Effect of neonatal isolation on outcome following neonatal seizures in rats--the role of corticosterone. Lai, M.C., Holmes, G.L., Lee, K.H., Yang, S.N., Wang, C.A., Wu, C.L., Tiao, M.M., Hsieh, C.S., Lee, C.H., Huang, L.T. Epilepsy Res. (2006) [Pubmed]
  8. Comparison of two different benzodiazepine binding proteins by peptide mapping after limited proteolysis. Sieghart, W. Brain Res. (1988) [Pubmed]
  9. Effect of clopidogrel treatment on ADP-induced phosphorylations in rat platelets. Savi, P., Artçanuthurry, V., Bornia, J., Grelac, F., Maclouf, J., Levy-Toledano, S., Herbert, J.M. Br. J. Haematol. (1997) [Pubmed]
  10. Photoaffinity labeling of different benzodiazepine receptors at physiological temperature. Eichinger, A., Sieghart, W. J. Neurochem. (1984) [Pubmed]
  11. Cutaneous wounds produced by capsaicin treatment of newborn rats are due to trophic disturbances. Carrillo, P., Camacho, M., Manzo, J., Martinez-Gomez, M., Salas, M., Pacheco, P. Neurotoxicology and teratology. (1998) [Pubmed]
  12. Serotoninergic depression of auditory evoked responses recorded in the rat hippocampus: effect of repeated buspirone treatment. O'Connor, J.J., Rowan, M.J., Anwyl, R. Brain Res. (1992) [Pubmed]
  13. Ovarian hormones can organize the rat corpus callosum in adulthood. Bimonte, H.A., Mack, C.M., Stavnezer, A.J., Denenberg, V.H. Brain Res. Dev. Brain Res. (2000) [Pubmed]
 
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