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MeSH Review

Moloney murine sarcoma virus

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Disease relevance of Moloney murine sarcoma virus


High impact information on Moloney murine sarcoma virus

  • We have partially purified, from rat liver, a nuclear protein fraction with sequence-specific affinity to a promoter domain shared by the herpesvirus tk gene and the Moloney murine sarcoma virus LTR [6].
  • 3T3 FL cells transformed by Moloney sarcoma virus showed changes in many polypeptides, including several major components: the disappearance or modification of a component of 60,000 daltons, an increased concentration and shift in pl of a glycoprotein of 48,000 daltons, and the apparent loss of several smaller polypeptides [7].
  • Cells transformed by certain strains of Moloney sarcoma virus contain murine p60 [8].
  • However, expression of the c-mos gene, the cellular homologue of the transforming gene of Moloney murine sarcoma virus, has not been detected in normal mouse cells or tissues [9].
  • A mouse ets-1 cDNA clone was obtained by screening a mouse thymus cDNA expression library with a double-stranded oligonucleotide probe representing 20 bp of the Moloney murine sarcoma virus (MSV) long terminal repeat (LTR) [10].

Chemical compound and disease context of Moloney murine sarcoma virus


Biological context of Moloney murine sarcoma virus


Anatomical context of Moloney murine sarcoma virus


Gene context of Moloney murine sarcoma virus


Analytical, diagnostic and therapeutic context of Moloney murine sarcoma virus


  1. Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis. Blair, D.G., Oskarsson, M., Wood, T.G., McClements, W.L., Fischinger, P.J., Vande Woude, G.G. Science (1981) [Pubmed]
  2. Virus-induced animal model of osteosarcoma in the rat: Morphologic and biochemical studies. Olson, H.M., Capen, C.C. Am. J. Pathol. (1977) [Pubmed]
  3. Expression and phenotypic alterations caused by an inducible transforming ras oncogene introduced into rat liver epithelial cells. Huber, B.E., Cordingley, M.G. Oncogene (1988) [Pubmed]
  4. Phosphorylation and nucleic acid binding properties of m1 Moloney murine sarcoma virus-specific pP60gag. Oskarsson, M.K., Long, C.W., Robey, W.G., Scherer, M.A., Vande Woude, G.F. J. Virol. (1977) [Pubmed]
  5. Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine. Naesens, L., Balzarini, J., Bischofberger, N., De Clercq, E. Antimicrob. Agents Chemother. (1996) [Pubmed]
  6. Homologous recognition of a promoter domain common to the MSV LTR and the HSV tk gene. Graves, B.J., Johnson, P.F., McKnight, S.L. Cell (1986) [Pubmed]
  7. Polypeptide maps of cells infected with murine type C leukemia or sarcoma oncovirus. Strand, M., August, J.T. Cell (1978) [Pubmed]
  8. Cells transformed by certain strains of Moloney sarcoma virus contain murine p60. Robey, W.G., Oskarsson, M.K., Woude, G.F., Naso, R.B., Arlinghaus, R.B., Haapala, D.K., Fischinger, P.J. Cell (1977) [Pubmed]
  9. Expression of c-mos proto-oncogene transcripts in mouse tissues. Propst, F., Vande Woude, G.F. Nature (1985) [Pubmed]
  10. Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus. Gunther, C.V., Nye, J.A., Bryner, R.S., Graves, B.J. Genes Dev. (1990) [Pubmed]
  11. Moloney murine sarcoma virus tumors in CBA/J mice: chemopreventive and chemotherapeutic actions of supplemental beta-carotene. Seifter, E., Rettura, G., Padawer, J., Levenson, S.M. J. Natl. Cancer Inst. (1982) [Pubmed]
  12. Changes caused in the homing patterns of chromium 51-labeled lymphoid cells by Moloney sarcoma virus infection. Gillette, R.W., Fox, A. J. Natl. Cancer Inst. (1977) [Pubmed]
  13. Lysine residue 121 in the proposed ATP-binding site of the v-mos protein is required for transformation. Hannink, M., Donoghue, D.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  14. Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eucaryotic cells. Blochlinger, K., Diggelmann, H. Mol. Cell. Biol. (1984) [Pubmed]
  15. Autocrine activation of the hepatocyte growth factor receptor/met tyrosine kinase induces tumor cell motility by regulating pseudopodial protrusion. Vadnais, J., Nault, G., Daher, Z., Amraei, M., Dodier, Y., Nabi, I.R., Noël, J. J. Biol. Chem. (2002) [Pubmed]
  16. Nuclear factors binding specific sequences within the immunoglobulin enhancer interact differentially with other enhancer elements. Schlokat, U., Bohmann, D., Schöler, H., Gruss, P. EMBO J. (1986) [Pubmed]
  17. Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in culture. Topol, L.Z., Marx, M., Laugier, D., Bogdanova, N.N., Boubnov, N.V., Clausen, P.A., Calothy, G., Blair, D.G. Mol. Cell. Biol. (1997) [Pubmed]
  18. Transcriptional activation through ETS domain binding sites in the cytochrome c oxidase subunit IV gene. Virbasius, J.V., Scarpulla, R.C. Mol. Cell. Biol. (1991) [Pubmed]
  19. In vitro studies of cell-mediated immunity to Moloney murine leukemia virus and Moloney leukemia-associated surface antigens. Ng, A.K., Ames, R.S., McIntire, R.K., Herberman, R.B. Cancer Res. (1979) [Pubmed]
  20. Growth of murine sarcoma and murine xenotropic leukemia viruses in Japanese quail: induction of tumors and development of continuous tumor cell lines. Robey, W.G., Kuenzel, W.J., Vande Woude, G.F., Fischinger, P.J. Cancer Res. (1982) [Pubmed]
  21. Monoclonal IgM antibodies that inhibit primary Moloney murine sarcoma growth. Lamon, E.W., Powell, T.J., Walia, A.S., Lidin, B.I., Srinivas, R.V., Baskin, J.G., Kearney, J.F. J. Natl. Cancer Inst. (1987) [Pubmed]
  22. Expression of NF-L and NF-M in fibroblasts reveals coassembly of neurofilament and vimentin subunits. Monteiro, M.J., Cleveland, D.W. J. Cell Biol. (1989) [Pubmed]
  23. Retrovirus-induced changes in major histocompatibility complex antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes. Flyer, D.C., Burakoff, S.J., Faller, D.V. J. Immunol. (1985) [Pubmed]
  24. Insulin-like growth factor-II is an autocrine survival factor for differentiating myoblasts. Stewart, C.E., Rotwein, P. J. Biol. Chem. (1996) [Pubmed]
  25. Expression and characterization of recombinant human protein S in heterologous cells--studies of the interaction of amino acid residues leu-608 to glu-612 with human C4b-binding protein. Chang, G.T., Ploos van Amstel, H.K., Hessing, M., Reitsma, P.H., Bertina, R.M., Bouma, B.N. Thromb. Haemost. (1992) [Pubmed]
  26. Proliferin, a prolactin/growth hormone-like peptide represses myogenic-specific transcription by the suppression of an essential serum response factor-like DNA-binding activity. Muscat, G.E., Gobius, K., Emery, J. Mol. Endocrinol. (1991) [Pubmed]
  27. Human proto-oncogene c-mos maps to 8q11. Caubet, J.F., Mathieu-Mahul, D., Bernheim, A., Larsen, C.J., Berger, R. EMBO J. (1985) [Pubmed]
  28. Moloney murine sarcoma virus encoded p37mos expressed in yeast has protein kinase activity. Singh, B., Wittenberg, C., Reed, S.I., Arlinghaus, R.B. Virology (1986) [Pubmed]
  29. Invasiveness and chemotactic activity of oncogene transformed NIH/3T3 cells. Melchiori, A., Carlone, S., Allavena, G., Aresu, O., Parodi, S., Aaronson, S.A., Albini, A. Anticancer Res. (1990) [Pubmed]
  30. Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions. Rajasekaran, A.K., Hojo, M., Huima, T., Rodriguez-Boulan, E. J. Cell Biol. (1996) [Pubmed]
  31. Defects in lens fiber differentiation are linked to c-mos overexpression in transgenic mice. Khillan, J.S., Oskarsson, M.K., Propst, F., Kuwabara, T., Vande Woude, G.F., Westphal, H. Genes Dev. (1987) [Pubmed]
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