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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

Dp  -  DP transcription factor

Drosophila melanogaster

Synonyms: 49Fk, CG4654, DDP1, DP, DP1, ...
 
 
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High impact information on Dp

  • ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP [1].
  • We screened for mutations that disrupt G1-S transcription late in Drosophila embryogenesis and identified five mutations in the dDP gene [2].
  • Elevated expression of dE2F and dDP caused apoptosis in the eye disc [3].
  • Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye [3].
  • In the absence of dDP, the levels of dE2F1 and dE2F2 decline dramatically, and vice versa [4].
 

Biological context of Dp

 

Anatomical context of Dp

  • Mutation of dDP in the germline also prevents nurse cell cytoplasm transfer to the oocyte, resulting in a 'dumpless' phenotype that blocks oocyte development [8].
  • In a fraction of the mutant egg chambers the germ cells execute one extra round of mitosis, suggesting that in this tissue dDP is uniquely utilized for cell cycle arrest rather than cell cycle progression [8].
 

Physical interactions of Dp

  • We show that a Drosophila DP protein which can interact co-operatively with E2F proteins is a physiological DNA binding component of Drosophila DRTF1/E2F [9].
 

Other interactions of Dp

  • Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program [2].
  • We suggest that dE2F-dDP contributes to the expression of two classes of gene products: replication factors, whose abundance has a graded effect on replication, and cyclin E, which triggers an all-or-nothing transition from G1 to S phase [5].
  • These differences correlate with differences in the magnitude of the replication defects in follicle cells, which attain an inappropriate 32C DNA content in both Rbf1 and Dp mutants but not in E2f2 mutants [6].
  • Mutation of E2f2, Dp, or Rbf1 causes ectopic DNA replication throughout the follicle cell genome during gene amplification cycles [6].

References

  1. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Royzman, I., Austin, R.J., Bosco, G., Bell, S.P., Orr-Weaver, T.L. Genes Dev. (1999) [Pubmed]
  2. Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Royzman, I., Whittaker, A.J., Orr-Weaver, T.L. Genes Dev. (1997) [Pubmed]
  3. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. Du, W., Xie, J.E., Dyson, N. EMBO J. (1996) [Pubmed]
  4. dDP is needed for normal cell proliferation. Frolov, M.V., Moon, N.S., Dyson, N.J. Mol. Cell. Biol. (2005) [Pubmed]
  5. Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition. Duronio, R.J., Bonnette, P.C., O'Farrell, P.H. Mol. Cell. Biol. (1998) [Pubmed]
  6. Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Cayirlioglu, P., Ward, W.O., Silver Key, S.C., Duronio, R.J. Mol. Cell. Biol. (2003) [Pubmed]
  7. E2F-induced S phase requires cyclin E. Duronio, R.J., Brook, A., Dyson, N., O'Farrell, P.H. Genes Dev. (1996) [Pubmed]
  8. A role for the DP subunit of the E2F transcription factor in axis determination during Drosophila oogenesis. Myster, D.L., Bonnette, P.C., Duronio, R.J. Development (2000) [Pubmed]
  9. Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster. Hao, X.F., Alphey, L., Bandara, L.R., Lam, E.W., Glover, D., La Thangue, N.B. J. Cell. Sci. (1995) [Pubmed]
 
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