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Gene Review

Tb927.8.5120  -  cytochrome c

Trypanosoma brucei brucei TREU927

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Disease relevance of Tb927.8.5120


High impact information on Tb927.8.5120


Biological context of Tb927.8.5120


Anatomical context of Tb927.8.5120


Associations of Tb927.8.5120 with chemical compounds


Analytical, diagnostic and therapeutic context of Tb927.8.5120

  • Western blots, however, confirm that steady-state levels of cytochrome c are severely depressed in bloodstream forms [14].
  • RNase T1 protection studies and Northern blot analyses demonstrated that bloodstream and procyclic form cells constitutively expressed the genes for two nuclear encoded cytochrome c reductase subunits, cytochrome c1 and subunit 4 [15].


  1. Maturation of the unusual single-cysteine (XXXCH) mitochondrial c-type cytochromes found in trypanosomatids must occur through a novel biogenesis pathway. Allen, J.W., Ginger, M.L., Ferguson, S.J. Biochem. J. (2004) [Pubmed]
  2. Differential expression of mitochondrial genes between life cycle stages of Trypanosoma brucei. Feagin, J.E., Stuart, K. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  3. Posttranscriptional regulation of cytochrome c expression during the developmental cycle of Trypanosoma brucei. Torri, A.F., Hajduk, S.L. Mol. Cell. Biol. (1988) [Pubmed]
  4. Diverse patterns of expression of the cytochrome c oxidase subunit I gene and unassigned reading frames 4 and 5 during the life cycle of Trypanosoma brucei. Jasmer, D.P., Feagin, J.E., Stuart, K. Mol. Cell. Biol. (1985) [Pubmed]
  5. Cytochrome c reductase purified from Crithidia fasciculata contains an atypical cytochrome c1. Priest, J.W., Hajduk, S.L. J. Biol. Chem. (1992) [Pubmed]
  6. Downregulation of the nuclear-encoded subunits of the complexes III and IV disrupts their respective complexes but not complex I in procyclic Trypanosoma brucei. Horváth, A., Horáková, E., Dunajcíková, P., Verner, Z., Pravdová, E., Slapetová, I., Cuninková, L., Lukes, J. Mol. Microbiol. (2005) [Pubmed]
  7. The sequence of the gene for cytochrome c oxidase subunit I, a frameshift containing gene for cytochrome c oxidase subunit II and seven unassigned reading frames in Trypanosoma brucei mitochrondrial maxi-circle DNA. Hensgens, L.A., Brakenhoff, J., De Vries, B.F., Sloof, P., Tromp, M.C., Van Boom, J.H., Benne, R. Nucleic Acids Res. (1984) [Pubmed]
  8. Identification of mitochondrial genes in Trypanosoma brucei and homology to cytochrome c oxidase II in two different reading frames. Payne, M., Rothwell, V., Jasmer, D.P., Feagin, J.E., Stuart, K. Mol. Biochem. Parasitol. (1985) [Pubmed]
  9. The role of succinate in the respiratory chain of Trypanosoma brucei procyclic trypomastigotes. Turrens, J.F. Biochem. J. (1989) [Pubmed]
  10. Alternative oxidase present in procyclic Trypanosoma brucei may act to lower the mitochondrial production of superoxide. Fang, J., Beattie, D.S. Arch. Biochem. Biophys. (2003) [Pubmed]
  11. Isolation and characterization of complex I, rotenone-sensitive NADH: ubiquinone oxidoreductase, from the procyclic forms of Trypanosoma brucei. Fang, J., Wang, Y., Beattie, D.S. Eur. J. Biochem. (2001) [Pubmed]
  12. A soluble fumarate reductase in Trypanosoma brucei procyclic trypomastigotes. Mracek, J., Snyder, S.J., Chavez, U.B., Turrens, J.F. J. Protozool. (1991) [Pubmed]
  13. Metabolic differentiation of bloodstream forms of Trypanosoma brucei brucei into procyclic forms. Effect of hydroxyurea, arabinosyl adenine, and serum omission. Markos, A., Blahůsková, A., Kalous, M., Bysková, E., Byska, K., Nohýnková, E. Folia Parasitol. (1989) [Pubmed]
  14. Protein stability regulates the expression of cytochrome c during the developmental cycle of Trypanosoma brucei. Torri, A.F., Bertrand, K.I., Hajduk, S.L. Mol. Biochem. Parasitol. (1993) [Pubmed]
  15. Developmental regulation of Trypanosoma brucei cytochrome c reductase during bloodstream to procyclic differentiation. Priest, J.W., Hajduk, S.L. Mol. Biochem. Parasitol. (1994) [Pubmed]
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