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Gene Review

Tb10.6k15.3640  -  alternative oxidase

Trypanosoma brucei brucei TREU927

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Disease relevance of Tb10.6k15.3640


High impact information on Tb10.6k15.3640


Chemical compound and disease context of Tb10.6k15.3640


Biological context of Tb10.6k15.3640


Anatomical context of Tb10.6k15.3640


Associations of Tb10.6k15.3640 with chemical compounds


Other interactions of Tb10.6k15.3640


Analytical, diagnostic and therapeutic context of Tb10.6k15.3640

  • The trypanosome alternative oxidase (TAO) is an attractive target for chemotherapy for the diseases caused by African trypanosomes because there is no equivalent enzyme in mammalian hosts [18].


  1. Overproduction of highly active trypanosome alternative oxidase in Escherichia coli heme-deficient mutant. Fukai, Y., Nihei, C., Kawai, K., Yabu, Y., Suzuki, T., Ohta, N., Minagawa, N., Nagai, K., Kita, K. Parasitol. Int. (2003) [Pubmed]
  2. Expression of a major surface protein of Trypanosoma brucei insect forms is controlled by the activity of mitochondrial enzymes. Vassella, E., Probst, M., Schneider, A., Studer, E., Renggli, C.K., Roditi, I. Mol. Biol. Cell (2004) [Pubmed]
  3. Site-directed mutagenesis reveals the essentiality of the conserved residues in the putative diiron active site of the trypanosome alternative oxidase. Ajayi, W.U., Chaudhuri, M., Hill, G.C. J. Biol. Chem. (2002) [Pubmed]
  4. Roles of triosephosphate isomerase and aerobic metabolism in Trypanosoma brucei. Helfert, S., Estévez, A.M., Bakker, B., Michels, P., Clayton, C. Biochem. J. (2001) [Pubmed]
  5. N-n-alkyl-3,4-dihydroxybenzamides as inhibitors of the trypanosome alternative oxidase: activity in vitro and in vivo. Grady, R.W., Bienen, E.J., Dieck, H.A., Saric, M., Clarkson, A.B. Antimicrob. Agents Chemother. (1993) [Pubmed]
  6. Alternative oxidase present in procyclic Trypanosoma brucei may act to lower the mitochondrial production of superoxide. Fang, J., Beattie, D.S. Arch. Biochem. Biophys. (2003) [Pubmed]
  7. Functional expression of the ascofuranone-sensitive Trypanosoma brucei brucei alternative oxidase in the cytoplasmic membrane of Escherichia coli. Fukai, Y., Amino, H., Hirawake, H., Yabu, Y., Ohta, N., Minagawa, N., Sakajo, S., Yoshimoto, A., Nagai, K., Takamiya, S., Kojima, S., Kita, K. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1999) [Pubmed]
  8. Trypanosome alternative oxidase is regulated post-transcriptionally at the level of RNA stability. Chaudhuri, M., Sharan, R., Hill, G.C. J. Eukaryot. Microbiol. (2002) [Pubmed]
  9. Novel inhibitors of the trypanosome alternative oxidase inhibit Trypanosoma brucei brucei growth and respiration. Ott, R., Chibale, K., Anderson, S., Chipeleme, A., Chaudhuri, M., Guerrah, A., Colowick, N., Hill, G.C. Acta Trop. (2006) [Pubmed]
  10. Strain-specific difference in amino acid sequences of trypanosome alternative oxidase. Fukai, Y., Nihei, C., Yabu, Y., Suzuki, T., Ohta, N., Minagawa, N., Nagai, K., Kita, K. Parasitol. Int. (2002) [Pubmed]
  11. The trypanosome alternative oxidase exists as a monomer in Trypanosoma brucei mitochondria. Chaudhuri, M., Ott, R.D., Saha, L., Williams, S., Hill, G.C. Parasitol. Res. (2005) [Pubmed]
  12. Growth inhibition of bloodstream forms of Trypanosoma brucei by the iron chelator deferoxamine. Breidbach, T., Scory, S., Krauth-Siegel, R.L., Steverding, D. Int. J. Parasitol. (2002) [Pubmed]
  13. Characterization of the respiratory chain of Leishmania donovani promastigotes. Santhamma, K.R., Bhaduri, A. Mol. Biochem. Parasitol. (1995) [Pubmed]
  14. Purification of sn-glycerol-3-phosphate dehydrogenase from Trypanosoma brucei brucei. Kornblatt, J.A., Nthale, J., McOdimba, F. Biochem. Cell Biol. (1992) [Pubmed]
  15. Evaluation of rhodamine 123 as a probe for monitoring mitochondrial function in Trypanosoma brucei spp. Divo, A.A., Patton, C.L., Sartorelli, A.C. J. Eukaryot. Microbiol. (1993) [Pubmed]
  16. Molecular cloning and characterization of Trypanosoma vivax alternative oxidase (AOX) gene, a target of the trypanocide ascofuranone. Suzuki, T., Nihei, C., Yabu, Y., Hashimoto, T., Suzuki, M., Yoshida, A., Nagai, K., Hosokawa, T., Minagawa, N., Suzuki, S., Kita, K., Ohta, N. Parasitol. Int. (2004) [Pubmed]
  17. An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei brucei. Minagawa, N., Yabu, Y., Kita, K., Nagai, K., Ohta, N., Meguro, K., Sakajo, S., Yoshimoto, A. Mol. Biochem. Parasitol. (1997) [Pubmed]
  18. Competition between inhibitors of the trypanosome alternative oxidase (TAO) and reduced coenzyme Q9. Pollakis, G., Grady, R.W., Dieck, H.A., Clarkson, A.B. Biochem. Pharmacol. (1995) [Pubmed]
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