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Gene Review

ARHGEF1  -  Rho guanine nucleotide exchange factor...

Homo sapiens

Synonyms: 115 kDa guanine nucleotide exchange factor, GEF1, LBCL2, LSC, P115-RHOGEF, ...
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Disease relevance of ARHGEF1


High impact information on ARHGEF1


Biological context of ARHGEF1


Anatomical context of ARHGEF1


Associations of ARHGEF1 with chemical compounds


Other interactions of ARHGEF1


Analytical, diagnostic and therapeutic context of ARHGEF1


  1. Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression. Bourguignon, L.Y., Singleton, P.A., Zhu, H., Diedrich, F. J. Biol. Chem. (2003) [Pubmed]
  2. Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. Reuther, G.W., Lambert, Q.T., Booden, M.A., Wennerberg, K., Becknell, B., Marcucci, G., Sondek, J., Caligiuri, M.A., Der, C.J. J. Biol. Chem. (2001) [Pubmed]
  3. An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domains. Ishikawa, K., Toru, S., Tsunemi, T., Li, M., Kobayashi, K., Yokota, T., Amino, T., Owada, K., Fujigasaki, H., Sakamoto, M., Tomimitsu, H., Takashima, M., Kumagai, J., Noguchi, Y., Kawashima, Y., Ohkoshi, N., Ishida, G., Gomyoda, M., Yoshida, M., Hashizume, Y., Saito, Y., Murayama, S., Yamanouchi, H., Mizutani, T., Kondo, I., Toda, T., Mizusawa, H. Am. J. Hum. Genet. (2005) [Pubmed]
  4. Modulation of HIV-1 replication by a novel RhoA effector activity. Wang, L., Zhang, H., Solski, P.A., Hart, M.J., Der, C.J., Su, L. J. Immunol. (2000) [Pubmed]
  5. Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals. Sterpetti, P., Marucci, L., Candelaresi, C., Toksoz, D., Alpini, G., Ugili, L., Baroni, G.S., Macarri, G., Benedetti, A. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  6. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Hart, M.J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W.D., Gilman, A.G., Sternweis, P.C., Bollag, G. Science (1998) [Pubmed]
  7. p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Kozasa, T., Jiang, X., Hart, M.J., Sternweis, P.M., Singer, W.D., Gilman, A.G., Bollag, G., Sternweis, P.C. Science (1998) [Pubmed]
  8. Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton. Krendel, M., Zenke, F.T., Bokoch, G.M. Nat. Cell Biol. (2002) [Pubmed]
  9. Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. Young, P., Ehler, E., Gautel, M. J. Cell Biol. (2001) [Pubmed]
  10. Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. Holinstat, M., Mehta, D., Kozasa, T., Minshall, R.D., Malik, A.B. J. Biol. Chem. (2003) [Pubmed]
  11. Mapping the Galpha13 binding interface of the rgRGS domain of p115RhoGEF. Chen, Z., Singer, W.D., Wells, C.D., Sprang, S.R., Sternweis, P.C. J. Biol. Chem. (2003) [Pubmed]
  12. Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues. Aasheim, H.C., Pedeutour, F., Smeland, E.B. Oncogene (1997) [Pubmed]
  13. Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. Bhattacharyya, R., Wedegaertner, P.B. J. Biol. Chem. (2000) [Pubmed]
  14. Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. Wells, C.D., Gutowski, S., Bollag, G., Sternweis, P.C. J. Biol. Chem. (2001) [Pubmed]
  15. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. Fukuhara, S., Murga, C., Zohar, M., Igishi, T., Gutkind, J.S. J. Biol. Chem. (1999) [Pubmed]
  16. Critical role of lysine 204 in switch I region of Galpha13 for regulation of p115RhoGEF and leukemia-associated RhoGEF. Nakamura, S., Kreutz, B., Tanabe, S., Suzuki, N., Kozasa, T. Mol. Pharmacol. (2004) [Pubmed]
  17. Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. Bhattacharyya, R., Wedegaertner, P.B. Biochem. J. (2003) [Pubmed]
  18. Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. Kristelly, R., Gao, G., Tesmer, J.J. J. Biol. Chem. (2004) [Pubmed]
  19. Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. Park, B., Nguyen, N.T., Dutt, P., Merdek, K.D., Bashar, M., Sterpetti, P., Tosolini, A., Testa, J.R., Toksoz, D. J. Biol. Chem. (2002) [Pubmed]
  20. Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential. Chikumi, H., Barac, A., Behbahani, B., Gao, Y., Teramoto, H., Zheng, Y., Gutkind, J.S. Oncogene (2004) [Pubmed]
  21. Mechanisms for reversible regulation between G13 and Rho exchange factors. Wells, C.D., Liu, M.Y., Jackson, M., Gutowski, S., Sternweis, P.M., Rothstein, J.D., Kozasa, T., Sternweis, P.C. J. Biol. Chem. (2002) [Pubmed]
  22. A t(2;19)(p13;p13.2) in a giant invasive cardiac lipoma from a patient with multiple lipomatosis. Vaughan, C.J., Weremowicz, S., Goldstein, M.M., Casey, M., Hart, M., Hahn, R.T., Devereux, R.B., Girardi, L., Schoen, F.J., Fletcher, J.A., Morton, C.C., Basson, C.T. Genes Chromosomes Cancer (2000) [Pubmed]
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