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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

px  -  plexus

Drosophila melanogaster

Synonyms: CG4444, Dmel\CG4444, l(2)k08134, l(2)k08316
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High impact information on px

  • In this study, we performed in situ hybridization of stage-specific mouse embryos and report on a novel expression pattern of the HFH-4 gene in both the presumptive and differentiated choroid plexus epithelium, which is responsible for the synthesis and secretion of cerebrospinal fluid (CSF) proteins [1].
  • The fused gene is expressed highly in ependymal cells and the choroid plexus, tissues involved in the production and circulation of cerebral spinal fluid (CSF), suggesting that loss of mFu disrupts CSF homeostasis [2].
  • We propose that the vein differentiation takes place by inactivation of the plexus-mediated repression by prepattern genes such as knirps [3].
  • Repression of the wing vein development in Drosophila by the nuclear matrix protein plexus [3].
  • We present an analysis of the gene plexus, whose loss of function causes an excess vein phenotype [3].

Anatomical context of px


Other interactions of px

  • Molecular cloning revealed that plexus encodes a novel 1990-amino acid protein with cysteine-rich motifs [3].
  • In the absence of egh, R1-R6 axons form a disorganized lamina plexus and some R1-R6 axons project abnormally to the medulla instead of the lamina [9].
  • The study of relationships between emc and different genes involved in wing development reveal strong genetic interactions with genes of the Ras signalling pathway (torpedo, vein, veinlet and Gap), blistered, plexus and net, in both adult wing phenotypes and cell behaviour in genetic mosaics [10].


  1. The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo. Lim, L., Zhou, H., Costa, R.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  2. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Merchant, M., Evangelista, M., Luoh, S.M., Frantz, G.D., Chalasani, S., Carano, R.A., van Hoy, M., Ramirez, J., Ogasawara, A.K., McFarland, L.M., Filvaroff, E.H., French, D.M., de Sauvage, F.J. Mol. Cell. Biol. (2005) [Pubmed]
  3. Repression of the wing vein development in Drosophila by the nuclear matrix protein plexus. Matakatsu, H., Tadokoro, R., Gamo, S., Hayashi, S. Development (1999) [Pubmed]
  4. Developmental expression of G proteins in a migratory population of embryonic neurons. Horgan, A.M., Lagrange, M.T., Copenhaver, P.F. Development (1994) [Pubmed]
  5. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. Furuta, Y., Piston, D.W., Hogan, B.L. Development (1997) [Pubmed]
  6. Expression of ciliary tektins in brain and sensory development. Norrander, J., Larsson, M., Ståhl, S., Höög, C., Linck, R. J. Neurosci. (1998) [Pubmed]
  7. Ultrastructure of capitate projections in the optic neuropil of Diptera. Stark, W.S., Carlson, S.D. Cell Tissue Res. (1986) [Pubmed]
  8. Immunochemical localization of calcium/calmodulin-dependent protein kinase I. Picciotto, M.R., Zoli, M., Bertuzzi, G., Nairn, A.C. Synapse (1995) [Pubmed]
  9. The egghead gene is required for compartmentalization in Drosophila optic lobe development. Fan, Y., Soller, M., Flister, S., Hollmann, M., Müller, M., Bello, B., Egger, B., White, K., Schäfer, M.A., Reichert, H. Dev. Biol. (2005) [Pubmed]
  10. Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila. Baonza, A., García-Bellido, A. Mech. Dev. (1999) [Pubmed]
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