Disease relevance of SAB0073

• Neutrophil bactericidal activity against Staphylococcus aureus adherent on biological surfaces. Surface-bound extracellular matrix proteins activate intracellular killing by oxygen-dependent and -independent mechanisms [1].
• Previous studies showed that Staphylococcus aureus expresses a collagen-binding MSCRAMM (Microbial Surface Component Recognizing Adhesive Matrix Molecules), CNA, that is necessary and sufficient for S. aureus cells to adhere to cartilage and is a virulence factor in experimental septic arthritis [2].
• Conversely, the detectable coating decreased rapidly as a function of time after ascites tumor cells were explanted in vitro at 37 degrees C. Iodoacetamide did partially block this 37 degree C in vitro-induced "uncoating process". Surface-bound Ig could also be released from in vivo-coated tumor cells treated at low pH in vitro [3].
• Based on the new findings and in view of the increasing incidence of nosocomial infections and antibiotic resistances, the German Robert-Koch-Institut has issued completely revised recommendations on Household Cleaning and Surface Disinfection [4].
• The nasal mucosa in immunodeficiency. Surface morphology, mucociliary function and bacteriological findings in adult patients with common variable immunodeficiency or selective IgA deficiency [5].

High impact information on SAB0073

• CONCLUSIONS: Surface-enhanced binding, previously shown for strongly dimerizing glycopeptide antibiotics to normal -D-alanyl-D-alanine-terminating cell-wall precursors, is now demonstrated for CE to the surface of models of VanA- and VanB-resistant bacteria [6].
• This current presentation describes the in vitro and in vivo characterization of Aurexis (tefibazumab), a humanized monoclonal antibody that exhibits a high affinity and specificity and for the Staphylococcus aureus MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) protein ClfA [7].

Analytical, diagnostic and therapeutic context of SAB0073

• A range of commercially available naso-gastric and naso-enteric tubes was examined by scanning electron microscopy (S.E.M.). Surface irregularities in which micro-organisms could become trapped were observed on the internal walls of all the samples [8].
• Site-Directed Mutagenesis to Assess the Binding Capacity of Class S Protein of Staphylococcus aureus Leucotoxins to the Surface of Polymorphonuclear Cells [9].
• Microbial count measurements were taken with an S.A.S. (Surface Air System) sampler, to ascertain the total bacterial count at 37 degrees C, and the fungal particle, Staphylococcus aureus and Pseudomonas aeruginosa counts [10].

References