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Gene Review

SAB0073  -  surface protein

Staphylococcus aureus RF122

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Disease relevance of SAB0073


High impact information on SAB0073

  • CONCLUSIONS: Surface-enhanced binding, previously shown for strongly dimerizing glycopeptide antibiotics to normal -D-alanyl-D-alanine-terminating cell-wall precursors, is now demonstrated for CE to the surface of models of VanA- and VanB-resistant bacteria [6].
  • This current presentation describes the in vitro and in vivo characterization of Aurexis (tefibazumab), a humanized monoclonal antibody that exhibits a high affinity and specificity and for the Staphylococcus aureus MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules) protein ClfA [7].

Analytical, diagnostic and therapeutic context of SAB0073


  1. Neutrophil bactericidal activity against Staphylococcus aureus adherent on biological surfaces. Surface-bound extracellular matrix proteins activate intracellular killing by oxygen-dependent and -independent mechanisms. Hermann, M., Jaconi, M.E., Dahlgren, C., Waldvogel, F.A., Stendahl, O., Lew, D.P. J. Clin. Invest. (1990) [Pubmed]
  2. Monoclonal antibodies to CNA, a collagen-binding microbial surface component recognizing adhesive matrix molecules, detach Staphylococcus aureus from a collagen substrate. Visai, L., Xu, Y., Casolini, F., Rindi, S., Höök, M., Speziale, P. J. Biol. Chem. (2000) [Pubmed]
  3. Tumor-bound immunoglobulins. I. Further analysis of the characteristics of binding of immunoglobulins to in vivo-grown tumor cells. Dorval, G., Witz, I.P., Klein, E., Wigzell, H. Int. J. Cancer (1976) [Pubmed]
  4. Household cleaning and surface disinfection: new insights and strategies. Exner, M., Vacata, V., Hornei, B., Dietlein, E., Gebel, J. J. Hosp. Infect. (2004) [Pubmed]
  5. The nasal mucosa in immunodeficiency. Surface morphology, mucociliary function and bacteriological findings in adult patients with common variable immunodeficiency or selective IgA deficiency. Karlsson, G., Hansson, H.A., Petruson, B., Björkander, J. Acta Otolaryngol. (1985) [Pubmed]
  6. 19F NMR in the measurement of binding affinities of chloroeremomycin to model bacterial cell-wall surfaces that mimic VanA and VanB resistance. Entress, R.M., Dancer, R.J., O'Brien, D.P., Try, A.C., Cooper, M.A., Williams, D.H. Chem. Biol. (1998) [Pubmed]
  7. A humanized monoclonal antibody targeting Staphylococcus aureus. Patti, J.M. Vaccine (2004) [Pubmed]
  8. Scanning electron microscopy of the internal wall topography of enteral feeding tubes. Anderton, A. Clinical nutrition (Edinburgh, Scotland) (1984) [Pubmed]
  9. Site-Directed Mutagenesis to Assess the Binding Capacity of Class S Protein of Staphylococcus aureus Leucotoxins to the Surface of Polymorphonuclear Cells. Moussa, L.B., Werner, S., Coraiola, M., Colin, D.A., Keller, D., Sanni, A., Serra, M.D., Monteil, H., Prévost, G. J. Biomed. Biotechnol. (2006) [Pubmed]
  10. Indoor air climate and microbiological airborne: contamination in various hospital areas. Berardi, B.M., Leoni, E. Zentralblatt für Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine. (1993) [Pubmed]
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