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Chemical Compound Review

iodoacetamide     2-iodoethanamide

Synonyms: Surauto, iodoacetoamide, Anti-Mek, sJYHCaVIKTp@, Lopac-I-1149, ...
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Disease relevance of iodoacetamide


Psychiatry related information on iodoacetamide


High impact information on iodoacetamide

  • Monomeric MBP can be isolated from serum by reduction of serum with dithiothreitol, alkylation with iodoacetamide, and acidification to pH 2 followed by fractionation on Sephadex G-50 at pH 2 [7].
  • Nodose and T9, T10 dorsal root ganglia were removed 7 days after initiation of iodoacetamide treatment [2].
  • Long-term feeding with iodoacetamide also resulted in enhanced gastrin release and antral gastrin messenger RNA in response to a meal supplemented with AmAc, but not to a normal meal or one supplemented with sodium acetate [8].
  • Further, substrate (EGFR) and phosphatase have been separated: a membrane preparation of cells that have been treated with epidermal growth factor (EGF) and whose dephosphorylating enzymes have been permanently destroyed by iodoacetamide can be mixed with a membrane preparation from untreated cells which re-establishes EGFR dephosphorylation [9].
  • The ability of native PTI to bind thrombin was destroyed by incubation with iodoacetamide [10].

Chemical compound and disease context of iodoacetamide


Biological context of iodoacetamide


Anatomical context of iodoacetamide


Associations of iodoacetamide with other chemical compounds


Gene context of iodoacetamide

  • Preincubation with iodoacetamide prevented the formation of the two high-molecular-weight complexes without affecting noncovalent dimer formation or high-affinity IL-3 binding [30].
  • Grx1 and Grx2 were sensitive to inactivation by iodoacetamide and H(2)O(2) and exhibited similar pH dependence of catalytic activity [31].
  • In contrast with iodoacetamide-treated red cells, catalase was not inactivated by 3-AT in glutathione peroxidase-deficient erythrocytes [32].
  • Defensin interactions with either alpha 1-PI or alpha 1-ACT were not affected by iodoacetamide or high salt concentration [33].
  • Using an iodoacetamide derivative of the Eu3+-chelate of N-(p-benzoic acid)diethylenetriamine-N,N',N"-tetraacetic acid (DTTA), incorporation of one Eu3+ per IL8 molecule ([Eu3+]IL8-S72C) was achieved [34].

Analytical, diagnostic and therapeutic context of iodoacetamide


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