Disease relevance of O2ColV200

• DNA replication proteins of Escherichia coli [1].
• DNA replication proceeds normally in P2+-infected gro109 cells, but late phage proteins are not made [2].
• Production of simian virus 40 large tumor antigen in bacteria: altered DNA-binding specificity and dna-replication activity of underphosphorylated large tumor antigen [3].
• DNA replication fork arrest during the termination phase of chromosome replication in Bacillus subtilis is brought about by the replication terminator protein (RTP) bound to specific DNA terminator sequences (Ter sites) distributed throughout the terminus region [4].
• DNA replication on the randomly primed template was inhibited as compared to control (unmodified) DNA to the same extent by all three types of adducts, irrespective of whether polymerization was performed by Escherichia coli DNA polymerase I, modified T7 DNA polymerase or Thermus aquaticus (Taq) DNA polymerase [5].

High impact information on O2ColV200

• DNA replication divides the circular Escherichia coli chromosome into equal arms (replichores) [6].
• DNA replication of double-stranded simian virus 40 (SV40) origin-containing plasmids, which has been previously thought to be a species-specific process that occurs only with factors derived from primate cells, is catalyzed with an extract derived from embryos of the fruit fly Drosophila melanogaster [7].
• DNA replication normally occurs with high fidelity, but certain "slippery" regions of DNA with tracts of mono-, di-, and trinucleotide repeats are frequently mutation hot spots [8].
• DNA replication occurs in vivo with very high processivity, meaning that the replication complex assembles at the origin(s) of replication and then performs template-directed synthesis of DNA over virtually the entire genome without dissociation [9].
• DNA replication terminus (ter)-binding protein (TBP) in Escherichia coli binds specifically to the terminus (ter) site, and the resulting complex severely blocks DNA replication in an unique orientation by inhibiting the action of helicases [10].

Chemical compound and disease context of O2ColV200

• DNA replication in Escherichia coli is inhibited by uncouplers such as 2,4-dibromophenol and 3,3'4',5-tetrachlorosalicylanilide [11].

Biological context of O2ColV200

• DNA replication and recombination generate intertwined DNA intermediates that must be decatenated for chromosome segregation to occur [12].
• DNA replication-coupled inactivation of DnaA protein in vitro: a role for DnaA arginine-334 of the AAA+ Box VIII motif in ATP hydrolysis [13].
• DNA replication initiation, doubling of rate of phospholipid synthesis, and cell division in Escherichia coli [14].
• DNA replication in the dimorphic bacterium Caulobacter crescentus is tightly linked to its developmental cell cycle [15].
• DNA replication and indirect induction of the SOS response in Escherichia coli [16].

Anatomical context of O2ColV200

• DNA replication pattern and cell wall growth in Escherichia coli PAT 84 [17].

Associations of O2ColV200 with chemical compounds

• DNA replication fidelity with 8-oxodeoxyguanosine triphosphate [18].
• DNA replication past pyrimidine dimers in the absence of repair [19].

Analytical, diagnostic and therapeutic context of O2ColV200

• DNA replication enzymes in the thermophilic Archaea have previously attracted attention due to their obvious use in methods such as PCR [20].
• DNA replication in Escherichia coli gyrB(Ts) mutants analysed by flow cytometry [21].

References