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GDNF  -  glial cell derived neurotrophic factor

Bos taurus

 
 
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Disease relevance of GDNF

  • The objective of this work was determine whether rat BMSC express NGF and GDNF, in order to study its potential application for treatment of neurodegenerative diseases [1].
 

High impact information on GDNF

 

Anatomical context of GDNF

  • These data indicate that frozen-thawed bovine spermatogonial stem cells survive cryopreservation and can be maintained during coculture with a feeder cell line in which the maintenance is influenced by GDNF [3].
  • Numbers of single (A(s)) and paired (A(pr)) spermatogonia were significantly higher in GDNF treated cultures at Days 15 and 25 (P<0.01 and 0.05, respectively), and the ratio of A(s) to A(pr) and spermatogonial chains (A(al)) was also higher indicating enhanced self-renewal of the SSC [5].
  • We studied the development of primary co-cultures of prepubertal bovine Sertoli cells and A spermatogonia and the effect of glial cell line-derived neurotropic factor (GDNF) on the numbers and types of spermatogonia, the formation of spermatogonial colonies and the capacity of the cultured SSC to colonize a recipient mouse testis [5].
  • Expression and localization of GDNF in developing and adult adrenal chromaffin cells [4].
  • Most of the chromaffin cells within the adult rat adrenal medulla are GDNF immunoreactive, including both the noradrenergic and adrenergic subpopulations [4].
 

Analytical, diagnostic and therapeutic context of GDNF

References

  1. Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors. García, R., Aguiar, J., Alberti, E., de la Cuétara, K., Pavón, N. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Characterization of glial cell line-derived neurotrophic factor family receptor alpha-1 in peripheral nerve Schwann cells. Hase, A., Saito, F., Yamada, H., Arai, K., Shimizu, T., Matsumura, K. J. Neurochem. (2005) [Pubmed]
  3. Biological activity of cryopreserved bovine spermatogonial stem cells during in vitro culture. Oatley, J.M., Reeves, J.J., McLean, D.J. Biol. Reprod. (2004) [Pubmed]
  4. Expression and localization of GDNF in developing and adult adrenal chromaffin cells. Krieglstein, K., Deimling, F., Suter-Crazzolara, C., Unsicker, K. Cell Tissue Res. (1996) [Pubmed]
  5. Basic features of bovine spermatogonial culture and effects of glial cell line-derived neurotrophic factor. Aponte, P.M., Soda, T., van de Kant, H.J., de Rooij, D.G. Theriogenology (2006) [Pubmed]
  6. Lack of telomerase activity in rabbit bone marrow stromal cells during differentiation along neural pathway. Chen, Z.Z., Xu, R.X., Jiang, X.D., Teng, X.H., Li, G.T., Zhou, Y.X. Chin. J. Traumatol. (2006) [Pubmed]
 
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