Disease relevance of INCA1

• Chagas' disease in Peruvian Inca mummy [1].
• METHODS: The sample included children from the INCAP longitudinal trial (1969-1977), who had adequate birth weight (> -1 s.d.) (n = 79) [2].
• Severe high-altitude cerebral edema on the Inca Trail [3].
• The average daily energy intake for children 1-4 years old was 866 Kcal representing 60% of the 1973 level recommended by the Institute of Nutrition of Central America and Panama (INCAP), for this age group, and 76% of the recommended level on a body-weight basis [4].

High impact information on INCA1

• Although ample evidence indicates that INCA1 and INCA2 react covalently with cysteine 266, covalent derivatization alone is not sufficient for maximal inhibition of the calcineurin-PVIVIT interaction, because the maleimide INCA12 reacts with the same site and produces only very modest inhibition [5].
• Here we show that the binding site on calcineurin for INCA1, INCA2, and INCA6 is centered on cysteine 266 of calcineurin Aalpha and does not coincide with the core PXIXIT-binding site [5].
• A C1-inhibitor-complex assay (INCA): a method to detect C1 activation in vitro and in vivo [6].
• Seventy-eight boys and 60 girls in rural Guatemala received different amounts of food supplementation, pre- and postnatally, as part of the INCAP Longitudinal Study. Children were classified as High or Low Supplementation, based on supplemental caloric intake prenatally and from birth to four years [7].
• The INCA program converts Consort 30-generated fluorescence list mode data collected from Indo-1-stained cells to absolute intracellular calcium concentrations (nM Ca2+i) [8].

Biological context of INCA1

• Bone mineralization, the muscular volume, and the thickness of the adipose panniculus indicated the good nutritional state of the three Inca children [9].
• Inca and colonial settlement, coca cultivation and endemic disease in the tropical forest [10].
• Medical acupuncture enhances standard wilderness medical care: a case study from the Inca Trail, Machu Picchu, Peru, April 2, 1997 [11].

Anatomical context of INCA1

• The percentage of peripheral blood lymphocytes forming rosettes with sheep erythrocytes (E-rosettes) was determined at admission to the INCAP Clinical Center in eight acutely malnourished Guatemalan children, and again after 14 and 28-30 days of nutritional therapy [12].

Associations of INCA1 with chemical compounds

• The INCA provides a useful tool to assess the activation of C1 in the presence of C1-In, both in vitro and in vivo [6].
• The adrenocortical response to stress (as measured by the rate of corticosterone increase following capture) was reduced in the hottest summer months in black-throated sparrows, cactus wrens, and curve-billed thrashers, but less so in Abert's towhee an Inca dove [13].
• Urinary excretion of benzoylecgonine following ingestion of Health Inca Tea [14].
• Four males ingested one cup of Health Inca Tea which contained 1.87 mg of cocaine [14].

Analytical, diagnostic and therapeutic context of INCA1

• A radioimmunoassay (the C1-inhibitor-complex assay, INCA) is described for the detection of complexes that are composed of at least C1s and C1-inhibitor [6].
• MATERIALS AND METHODS: CT, conventional radiography, and dental radiography of Inca mummies were reviewed [9].

References