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Gene Review

INCA1  -  inhibitor of CDK, cyclin A1 interacting...

Homo sapiens

Synonyms: HSD45, Inhibitor of CDK interacting with cyclin A1, Protein INCA1
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Disease relevance of INCA1

  • Chagas' disease in Peruvian Inca mummy [1].
  • METHODS: The sample included children from the INCAP longitudinal trial (1969-1977), who had adequate birth weight (> -1 s.d.) (n = 79) [2].
  • Severe high-altitude cerebral edema on the Inca Trail [3].
  • The average daily energy intake for children 1-4 years old was 866 Kcal representing 60% of the 1973 level recommended by the Institute of Nutrition of Central America and Panama (INCAP), for this age group, and 76% of the recommended level on a body-weight basis [4].

High impact information on INCA1

  • Although ample evidence indicates that INCA1 and INCA2 react covalently with cysteine 266, covalent derivatization alone is not sufficient for maximal inhibition of the calcineurin-PVIVIT interaction, because the maleimide INCA12 reacts with the same site and produces only very modest inhibition [5].
  • Here we show that the binding site on calcineurin for INCA1, INCA2, and INCA6 is centered on cysteine 266 of calcineurin Aalpha and does not coincide with the core PXIXIT-binding site [5].
  • A C1-inhibitor-complex assay (INCA): a method to detect C1 activation in vitro and in vivo [6].
  • Seventy-eight boys and 60 girls in rural Guatemala received different amounts of food supplementation, pre- and postnatally, as part of the INCAP Longitudinal Study. Children were classified as High or Low Supplementation, based on supplemental caloric intake prenatally and from birth to four years [7].
  • The INCA program converts Consort 30-generated fluorescence list mode data collected from Indo-1-stained cells to absolute intracellular calcium concentrations (nM Ca2+i) [8].

Biological context of INCA1

  • Bone mineralization, the muscular volume, and the thickness of the adipose panniculus indicated the good nutritional state of the three Inca children [9].
  • Inca and colonial settlement, coca cultivation and endemic disease in the tropical forest [10].
  • Medical acupuncture enhances standard wilderness medical care: a case study from the Inca Trail, Machu Picchu, Peru, April 2, 1997 [11].

Anatomical context of INCA1

  • The percentage of peripheral blood lymphocytes forming rosettes with sheep erythrocytes (E-rosettes) was determined at admission to the INCAP Clinical Center in eight acutely malnourished Guatemalan children, and again after 14 and 28-30 days of nutritional therapy [12].

Associations of INCA1 with chemical compounds

  • The INCA provides a useful tool to assess the activation of C1 in the presence of C1-In, both in vitro and in vivo [6].
  • The adrenocortical response to stress (as measured by the rate of corticosterone increase following capture) was reduced in the hottest summer months in black-throated sparrows, cactus wrens, and curve-billed thrashers, but less so in Abert's towhee an Inca dove [13].
  • Urinary excretion of benzoylecgonine following ingestion of Health Inca Tea [14].
  • Four males ingested one cup of Health Inca Tea which contained 1.87 mg of cocaine [14].

Analytical, diagnostic and therapeutic context of INCA1

  • A radioimmunoassay (the C1-inhibitor-complex assay, INCA) is described for the detection of complexes that are composed of at least C1s and C1-inhibitor [6].
  • MATERIALS AND METHODS: CT, conventional radiography, and dental radiography of Inca mummies were reviewed [9].


  1. Chagas' disease in Peruvian Inca mummy. Fornaciari, G., Castagna, M., Viacava, P., Tognetti, A., Bevilacqua, G., Segura, E.L. Lancet (1992) [Pubmed]
  2. Growth retardation starts in the first three months of life among rural Guatemalan children. Rivera, J., Ruel, M.T. European journal of clinical nutrition. (1997) [Pubmed]
  3. Severe high-altitude cerebral edema on the Inca Trail. Hart, O. Journal of travel medicine : official publication of the International Society of Travel Medicine and the Asia Pacific Travel Health Association. (2004) [Pubmed]
  4. Dietary intakes of preschool children in LA Pa, El Salvador, Central America. Wolfe, P., Trowbridge, F.L. Archivos latinoamericanos de nutrición. (1980) [Pubmed]
  5. Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. Kang, S., Li, H., Rao, A., Hogan, P.G. J. Biol. Chem. (2005) [Pubmed]
  6. A C1-inhibitor-complex assay (INCA): a method to detect C1 activation in vitro and in vivo. Hack, C.E., Hannema, A.J., Eerenberg-Belmer, A.J., Out, T.A., Aalberse, R.C. J. Immunol. (1981) [Pubmed]
  7. Effects of nutritional supplementation on children's responses to novel, frustrating, and competitive situations. Barrett, D.E., Radke-Yarrow, M. Am. J. Clin. Nutr. (1985) [Pubmed]
  8. INCA: software for consort 30 analysis of flow cytometric calcium determinations. Keij, J.F., Griffioen, A.W., The, T.H., Rijkers, G.T. Cytometry. (1989) [Pubmed]
  9. Radiologic evaluation of the Llullaillaco mummies. Previgliano, C.H., Ceruti, C., Reinhard, J., Araoz, F.A., Diez, J.G. AJR. American journal of roentgenology. (2003) [Pubmed]
  10. Inca and colonial settlement, coca cultivation and endemic disease in the tropical forest. Gade, D.W. Journal of historical geography. (1979) [Pubmed]
  11. Medical acupuncture enhances standard wilderness medical care: a case study from the Inca Trail, Machu Picchu, Peru, April 2, 1997. Frank, B.L. Wilderness & environmental medicine. (1997) [Pubmed]
  12. Effects of nutritional recuperation on E-rosetting lymphocytes and in vitro response to thymosin in malnourished children. Cruz, J.R., Chew, F., Fernandez, R.A., Torun, B., Goldstein, A.L., Keusch, G.T. J. Pediatr. Gastroenterol. Nutr. (1987) [Pubmed]
  13. Seasonal changes of the adrenocortical response to stress in birds of the Sonoran Desert. Wingfield, J.C., Vleck, C.M., Moore, M.C. J. Exp. Zool. (1992) [Pubmed]
  14. Urinary excretion of benzoylecgonine following ingestion of Health Inca Tea. Jackson, G.F., Saady, J.J., Poklis, A. Forensic Sci. Int. (1991) [Pubmed]
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