Disease relevance of Endemic Diseases

• Recently, a high proportion of patients with late-stage Trypanosoma brucei gambiense trypanosomiasis, who had been treated with melarsoprol in some disease-endemic areas, subsequently relapsed [1].
• Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan [2].
• BACKGROUND: High rates of endemic disease and recurrent epidemics of serogroup A and C meningococcal meningitis continue to occur in sub-Saharan Africa. A meningococcal A + C polysaccharide diphtheria-toxoid-conjugated vaccine may address this issue [3].
• Malumfashi Endemic Diseases Research Project, V. Concurrent single dose metrifonate and niridazole in urinary schistosomiasis [4].
• The polymerase chain reaction is used increasingly widely for the diagnosis of both cutaneous and visceral leishmaniasis and for the identification of asymptomatic carriers in the population in endemic disease areas [5].

High impact information on Endemic Diseases

• Possible reasons for the lower-than-expected prevalence of lactose malabsorption in this population are the use of a physiological dose of lactose, and the fact that this population is well nourished and free from significant parasitism and other endemic diseases [6].
• The protective effect of polymorphic variants in erythrocyte-specific structural proteins or metabolic enzymes against the blood-stage of the disease is one of the clearest illustrations of this genetic modulation, and has suggested co-evolution of the Plasmodium parasite with its human host in areas of endemic disease [7].
• Elevation of the anti-Z immunoglobulin (Ig) antibody titer is a common feature of nasopharyngeal carcinoma (NPC) in areas where the disease endemic, whereas R levels have not been examined [8].
• The protein sequences of the IgA1 protease, TbpA and TbpB proteins differ between meningococci representative of serogroup A, subgroup IV-1 from epidemic disease in The Gambia and serogroup C, ET-37 complex from endemic disease in Mali [9].
• The antigen showed no cross-reactivity with sera from other endemic diseases or healthy controls [10].

Chemical compound and disease context of Endemic Diseases

• DATA SOURCES: Data from literature published at home and abroad on the control and research of schistosomiasis in China in biomedical journals and monographs, and a few data from the Office of Endemic Diseases Control, Ministry of Health, are collected [11].
• Cutaneous leishmaniasis (CL) is an endemic disease in Egypt. Systematic treatment with pentostam has its disadvantages and contraindications [12].
• These three compounds were toxic to SH-SY5Y neuroblastoma cells and inhibited mitochondrial respiratory complex I. It is possible that uptake of the benzylisoquinoline derivatives reticuline and N-methylcoculaurine and their accumulation in the brain may be related to the pathogenesis of the local endemic disease [13].

Biological context of Endemic Diseases

• The effect of fluorescent humic substances existing in the well water of Blackfoot disease endemic areas in Taiwan on prothrombin time and activated partial thromboplastin time in vitro [14].

Associations of Endemic Diseases with chemical compounds

• SETTING: The tuberculosis component of the Infectious and Endemic Disease Control Project in the People's Republic of China is the largest single tuberculosis control project in the world using directly-observed therapy and standardized intermittent regimens [15].
• The relationships between soil Se and human endemic diseases Keshan disease, Kashin-Back diseases and selenosis have been discussed [16].
• Fluorescent humic substances (FHS) in well water of Blackfoot disease endemic areas were purified and fractionated by Sephadex G-25 column chromatography [14].
• In this study, we treated this endemic disease with prostaglandin E1 (PGE1) infusion therapy [17].
• This preliminary report attempts to characterize T. solium transmission in communities with endemic disease in rural Mexico and illustrates some of the methodological problems faced by epidemiologists who study this disease [18].

Gene context of Endemic Diseases

• Preoccupied with the diagnosis of SARS (severe acute respiratory syndrome) in a SARS outbreak, doctors tend to overlook other endemic diseases, such as tuberculosis [19].
• Malumfashi Endemic Diseases Research Project, VI. Urinary schistosomiasis: abnormal urograms in infected males from the Malumfashi study area, northern Nigeria [20].
• The Rambouillet Forest, a Lyme disease-endemic area near Paris, France, was surveyed from September 1994 to October 1995 to determine the risk periods and zones for humans [21].
• CE is a significant endemic disease throughout the West Bank. The disease is acquired early in life and is more prevalent among females than males [22].
• Preliminary estimates of the direct costs associated with endemic diseases of livestock in Great Britain [23].

Analytical, diagnostic and therapeutic context of Endemic Diseases

• Malumfashi Endemic Diseases Research Project, III. Urinary schistosomiasis: a longitudinal study [24].

References