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Gene Review

ROS1  -  c-ros oncogene 1 , receptor tyrosine kinase

Gallus gallus

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Disease relevance of LOC396192


High impact information on LOC396192

  • Proto-oncogene c-ros codes for a molecule with structural features common to those of growth factor receptors and displays tissue specific and developmentally regulated expression [2].
  • Comparison of the deduced amino acid sequences of c-ros and v-ros shows two differences: v-ros contains a three-amino-acid insertion within the hydrophobic domain presumed to be involved in membrane association, and (ii) the carboxyl 12 amino acids of v-ros are completely different from those of the deduced c-ros sequence [2].
  • Finally, nucleotide sequences of c-ros DNA and UR2-associated helper viral genome at regions corresponding to the gag ros recombination site suggest that the junction has been formed by RNA splicing [2].
  • The deduced amino acid sequence of c-ros bears striking structural features similar to those of insulin and epidermal growth factor receptors, including the presumed hydrophobic membrane binding domain, amino acids flanking the domain, and the distance between the domain and the catalytic region of the kinase activity [2].
  • Heteroduplex mapping and nucleotide sequencing reveal that the v-ros sequences are distributed in nine exons ranging from 65 to 204 nucleotides on cellular ros (c-ros) DNA over a range of 11 kilobases [2].

Biological context of LOC396192


Anatomical context of LOC396192

  • Confirming our earlier study, we found that kidney is the organ that expresses the highest level of c-ros mRNA, in addition, we found a lower level of expression in gonad, thymus, bursa and brain [6].
  • In kidney c-ros was detected in all the epithelial cells of the collecting ducts, in intestine it was detected in the epithelial cells of villi and the underneath crypts [3].
  • Our results showed that in addition to kidney and intestine, low levels of c-ros mRNA could also be detected in lung, testis, thymus and bursa [3].
  • Those investigators suggested that c-ros may play a role in the development of those organelles [3].

Other interactions of LOC396192


Analytical, diagnostic and therapeutic context of LOC396192


  1. Molecular and biochemical bases for activation of the transforming potential of the proto-oncogene c-ros. Zong, C.S., Poon, B., Chen, J., Wang, L.H. J. Virol. (1993) [Pubmed]
  2. Proto-oncogene c-ros codes for a molecule with structural features common to those of growth factor receptors and displays tissue specific and developmentally regulated expression. Neckameyer, W.S., Shibuya, M., Hsu, M.T., Wang, L.H. Mol. Cell. Biol. (1986) [Pubmed]
  3. Tissue and epithelial cell-specific expression of chicken proto-oncogene c-ros in several organs suggests that it may play roles in their development and mature functions. Chen, J., Zong, C.S., Wang, L.H. Oncogene (1994) [Pubmed]
  4. Cloning and functional characterization of the chicken c-ros promoter. Chen, J., Tong, J., Tanaka-Sukegawa, I., Wang, L.H. Cell Growth Differ. (1995) [Pubmed]
  5. Avian sarcoma viruses. Wang, L.H., Hanafusa, H. Virus Res. (1988) [Pubmed]
  6. The proto-oncogene c-ros codes for a transmembrane tyrosine protein kinase sharing sequence and structural homology with sevenless protein of Drosophila melanogaster. Chen, J.M., Heller, D., Poon, B., Kang, L., Wang, L.H. Oncogene (1991) [Pubmed]
  7. Chicken proto-oncogene c-ros cDNA clones: identification of a c-ros RNA transcript and deduction of the amino acid sequence of the carboxyl terminus of the c-ros product. Podell, S.B., Sefton, B.M. Oncogene (1987) [Pubmed]
  8. Proto-oncogenes of genomic DNA in clinically normal animals of various species. Miyoshi, N., Tateyama, S., Ogawa, K., Nosaka, D., Ohashi, T., Sunyasootcharee, B. Am. J. Vet. Res. (1991) [Pubmed]
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