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Gene Review

LCK  -  lymphocyte-specific protein tyrosine kinase

Gallus gallus

Synonyms: P56LCK, tkl
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Disease relevance of P56LCK

  • One of these 42,000-dalton proteins was shown previously to be phosphorylated on tyrosine in chicken embryo cells transformed with various retroviruses whose transforming proteins possess tyrosine protein kinase activity [1].
  • The transforming protein P68gag-ros of avian sarcoma virus UR2 is a transmembrane tyrosine protein kinase molecule with the gag portion protruding extracellularly [2].
  • The TPK previously detected in the murine lymphoma (LSTRA) induced by the Moloney murine leukemia virus phosphorylates gastrin, the apparent Km is 65 microM and the maximum rate 1900 pmol/min per mg; the kinase is more efficient with MnCl2 than with MgCl2, is stimulated by NaVO3 and inhibited by ZnCl2 [3].

High impact information on P56LCK


Biological context of P56LCK


Anatomical context of P56LCK


Associations of P56LCK with chemical compounds

  • Modification of synthetic peptides related to lactate dehydrogenase (231-242) by protein carboxyl methyltransferase and tyrosine protein kinase: effects of introducing an isopeptide bond between aspartic acid-235 and serine-236 [14].

Physical interactions of P56LCK


Other interactions of P56LCK


  1. Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. Cooper, J.A., Sefton, B.M., Hunter, T. Mol. Cell. Biol. (1984) [Pubmed]
  2. Role of gag sequence in the biochemical properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros fusion protein. Jong, S.M., Wang, L.H. J. Virol. (1990) [Pubmed]
  3. Detection of tyrosine-specific protein kinases with gastrin as exogenous substrate. Fagard, R., Gacon, G., Boissel, J.P., Reibel, L., Piau, J.P., Fischer, S., Schapira, G., Accary, J.P. J. Biochem. Biophys. Methods (1985) [Pubmed]
  4. Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites. Kamps, M.P., Taylor, S.S., Sefton, B.M. Nature (1984) [Pubmed]
  5. Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. Reynolds, A.B., Vila, J., Lansing, T.J., Potts, W.M., Weber, M.J., Parsons, J.T. EMBO J. (1987) [Pubmed]
  6. Discrete primary locations of a tyrosine-protein kinase and of three proteins that contain phosphotyrosine in virally transformed chick fibroblasts. Cooper, J.A., Hunter, T. J. Cell Biol. (1982) [Pubmed]
  7. The putative transforming protein of S13 avian erythroblastosis virus is a transmembrane glycoprotein with an associated protein kinase activity. Hayman, M.J., Kitchener, G., Vogt, P.K., Beug, H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  8. The proto-oncogene c-ros codes for a transmembrane tyrosine protein kinase sharing sequence and structural homology with sevenless protein of Drosophila melanogaster. Chen, J.M., Heller, D., Poon, B., Kang, L., Wang, L.H. Oncogene (1991) [Pubmed]
  9. Chicken proto-oncogene c-ros cDNA clones: identification of a c-ros RNA transcript and deduction of the amino acid sequence of the carboxyl terminus of the c-ros product. Podell, S.B., Sefton, B.M. Oncogene (1987) [Pubmed]
  10. Signal transduction through the vasoactive intestinal peptide receptor stimulates phosphorylation of the tyrosine kinase pp60c-src. Koh, S.W. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  11. Regulation of the expression of proto-oncogene c-src by alternative RNA splicing in chicken skeletal muscle. Wang, L.H., Iijima, S., Dorai, T., Lin, B. Oncogene Res. (1987) [Pubmed]
  12. Purification and characterization of the major species of tyrosine protein kinase in rat liver. Wong, T.W., Goldberg, A.R. J. Biol. Chem. (1984) [Pubmed]
  13. VIP stimulates proliferation and differentiation of the cultured retinal pigment epithelium with disparate potencies. Koh, S.W., Kane, G.J. Cell Biol. Int. Rep. (1992) [Pubmed]
  14. Modification of synthetic peptides related to lactate dehydrogenase (231-242) by protein carboxyl methyltransferase and tyrosine protein kinase: effects of introducing an isopeptide bond between aspartic acid-235 and serine-236. Aswad, D.W., Johnson, B.A., Glass, D.B. Biochemistry (1987) [Pubmed]
  15. Avian CD4 and CD8 interact with a cellular tyrosine protein kinase homologous to mammalian p56lck. Veillette, A., Ratcliffe, M.J. Eur. J. Immunol. (1991) [Pubmed]
  16. tkl is the avian homolog of the mammalian lck tyrosine protein kinase gene. Chow, L.M., Ratcliffe, M.J., Veillette, A. Mol. Cell. Biol. (1992) [Pubmed]
  17. A discontinuous epitope on p36, the major substrate of src tyrosine-protein-kinase, brings the phosphorylation site into the neighbourhood of a consensus sequence for Ca2+/lipid-binding proteins. Johnsson, N., Johnsson, K., Weber, K. FEBS Lett. (1988) [Pubmed]
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