The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

LOC396408  -  protein-tyrosine kinase

Gallus gallus

This record was replaced with 395323.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of LOC396408

  • A hybrid receptor molecule composed of the extracellular ligand-binding domain of the human insulin receptor and the transmembrane and cytoplasmic (protein-tyrosine kinase) domains of the chicken sarcoma virus UR2 transforming protein p68gag-ros has been constructed and expressed in Chinese hamster ovary (CHO) cells [1].
  • This contrasts with the strong enhancement of outgrowth induced by the same inhibitors in cultured chick ciliary ganglion neurons and suggests that the mediation of outgrowth by PTK activity may vary in different neuronal types [2].
  • Stimulation by Bt2cAMP of epidermal mucous metaplasia in retinol-pretreated chick embryonic cultured skin, and its inhibition by herbimycin A, an inhibitor for protein-tyrosine kinase [3].
  • The transforming gene of avian sarcoma virus UR2, v-ros, encodes a receptor-like protein tyrosine kinase and differs from its proto-oncogene, c-ros, in its 5' truncation and fusion to viral gag, a three-amino-acid (aa) insertion in the transmembrane (TM) domain, and changes in the carboxyl region [4].

High impact information on LOC396408


Chemical compound and disease context of LOC396408


Biological context of LOC396408


Anatomical context of LOC396408


Associations of LOC396408 with chemical compounds


Enzymatic interactions of LOC396408


Other interactions of LOC396408


  1. Heterologous transmembrane signaling by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells. Ellis, L., Morgan, D.O., Jong, S.M., Wang, L.H., Roth, R.A., Rutter, W.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Inhibition of protein tyrosine kinases impairs axon extension in the embryonic optic tract. Worley, T., Holt, C. J. Neurosci. (1996) [Pubmed]
  3. Stimulation by Bt2cAMP of epidermal mucous metaplasia in retinol-pretreated chick embryonic cultured skin, and its inhibition by herbimycin A, an inhibitor for protein-tyrosine kinase. Obinata, A., Akimoto, Y., Hirano, H., Endo, H. Exp. Cell Res. (1991) [Pubmed]
  4. Molecular and biochemical bases for activation of the transforming potential of the proto-oncogene c-ros. Zong, C.S., Poon, B., Chen, J., Wang, L.H. J. Virol. (1993) [Pubmed]
  5. Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region. Jove, R., Kornbluth, S., Hanafusa, H. Cell (1987) [Pubmed]
  6. SH2 mutants of c-src that are host dependent for transformation are trans-dominant inhibitors of mouse cell transformation by activated c-src. Hirai, H., Varmus, H.E. Genes Dev. (1990) [Pubmed]
  7. The B lymphocyte adaptor molecule of 32 kD (Bam32) regulates B cell antigen receptor signaling and cell survival. Niiro, H., Maeda, A., Kurosaki, T., Clark, E.A. J. Exp. Med. (2002) [Pubmed]
  8. Tissue-dependent regulation of protein tyrosine kinase activity during embryonic development. Maher, P.A. J. Cell Biol. (1991) [Pubmed]
  9. Intestinal crypt stem cells possess high levels of cytoskeletal-associated phosphotyrosine-containing proteins and tyrosine kinase activity relative to differentiated enterocytes. Burgess, D.R., Jiang, W.P., Mamajiwalla, S., Kinsey, W. J. Cell Biol. (1989) [Pubmed]
  10. A major site of tyrosine phosphorylation within the SH2 domain of Fujinami sarcoma virus P130gag-fps is not required for protein-tyrosine kinase activity or transforming potential. Weinmaster, G.A., Middlemas, D.S., Hunter, T. J. Virol. (1988) [Pubmed]
  11. Characterization of a member of the immunoglobulin gene superfamily that possibly represents an additional class of growth factor receptor. Chou, Y.H., Hayman, M.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  12. Suboptimal cross-linking of antigen receptor induces Syk-dependent activation of p70S6 kinase through protein kinase C and phosphoinositol 3-kinase. Li, H.L., Davis, W., Puré, E. J. Biol. Chem. (1999) [Pubmed]
  13. Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress. Qin, S., Minami, Y., Hibi, M., Kurosaki, T., Yamamura, H. J. Biol. Chem. (1997) [Pubmed]
  14. The glypiated neuronal cell adhesion molecule contactin/F11 complexes with src-family protein tyrosine kinase Fyn. Zisch, A.H., D'Alessandri, L., Amrein, K., Ranscht, B., Winterhalter, K.H., Vaughan, L. Mol. Cell. Neurosci. (1995) [Pubmed]
  15. Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk. Lin, X., Ayrapetov, M.K., Lee, S., Parang, K., Sun, G. Biochemistry (2005) [Pubmed]
  16. Purification and characterization of a Src-related p57 protein-tyrosine kinase from Xenopus oocytes. Isolation of an inactive form of the enzyme and its activation and translocation upon fertilization. Sato, K., Aoto, M., Mori, K., Akasofu, S., Tokmakov, A.A., Sahara, S., Fukami, Y. J. Biol. Chem. (1996) [Pubmed]
  17. High levels of CD45 are coordinately expressed with CD4 and CD8 on avian thymocytes. Paramithiotis, E., Tkalec, L., Ratcliffe, M.J. J. Immunol. (1991) [Pubmed]
  18. Intestinal crypt cells contain higher levels of cytoskeletal-associated pp60c-src protein tyrosine kinase activity than do differentiated enterocytes. Cartwright, C.A., Mamajiwalla, S., Skolnick, S.A., Eckhart, W., Burgess, D.R. Oncogene (1993) [Pubmed]
  19. Angiogenic oligosaccharides of hyaluronan induce protein tyrosine kinase activity in endothelial cells and activate a cytoplasmic signal transduction pathway resulting in proliferation. Slevin, M., Krupinski, J., Kumar, S., Gaffney, J. Lab. Invest. (1998) [Pubmed]
  20. Activation of transforming potential of the human insulin receptor gene. Wang, L.H., Lin, B., Jong, S.M., Dixon, D., Ellis, L., Roth, R.A., Rutter, W.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  21. Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine. Okada, M., Howell, B.W., Broome, M.A., Cooper, J.A. J. Biol. Chem. (1993) [Pubmed]
  22. Regulation of swelling-activated chloride channels in embryonic chick heart cells. Wei, H., Mei, Y.A., Sun, J.T., Zhou, H.Q., Zhang, Z.H. Cell Res. (2003) [Pubmed]
  23. Inhibition of focal adhesion kinase expression correlates with changes in the cytoskeleton but not apoptosis in primary cultures of chick embryo cells. Ridyard, M.S., Sanders, E.J. Cell Biol. Int. (2001) [Pubmed]
  24. A protein tyrosine kinase involved in regulation of pp60c-src function. Okada, M., Nakagawa, H. J. Biol. Chem. (1989) [Pubmed]
  25. Chicken and mouse focal adhesion kinases are similar in structure at their amino termini. Devor, B.B., Zhang, X., Patel, S.K., Polte, T.R., Hanks, S.K. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
WikiGenes - Universities