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Gene Review

Ros1  -  Ros1 proto-oncogene

Mus musculus

Synonyms: Proto-oncogene c-Ros, Proto-oncogene c-Ros-1, Proto-oncogene tyrosine-protein kinase ROS, Receptor tyrosine kinase c-ros oncogene 1, Ros, ...
 
 
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Disease relevance of Ros1

 

High impact information on Ros1

  • The primary defect in the mutant animals was located in the epididymis, showing that c-ros controls appropriate development of the epithelia, particularly regionalization and terminal differentiation [5].
  • The c-ros gene was originally identified in mutant form as an oncogene [5].
  • The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis [5].
  • We demonstrate that c-ros is not required in a cell autonomous manner for male germ cell development or function [5].
  • The human c-ros gene (ROS) is located at chromosome region 6q16----6q22 [1].
 

Chemical compound and disease context of Ros1

 

Biological context of Ros1

  • The glutamate transporter-associated protein (GTRAP) 3-18 was detected in all epididymal regions independent of genotype, but a highly abundant novel transcript of 4.2 kilobases was found only in the initial segment of heterozygous c-ros mice [6].
  • Thus, the c-ros gene joins the c-myb oncogene, which is distal to the c-ros gene on the long arm of human chromosome 6, as a candidate for involvement in chromosome 6q deletions and rearrangements seen in various malignancies [1].
  • The c-ros proto-oncogene is the vertebrate homologue of the Drosophila sevenless tyrosine kinase receptor [7].
  • The c-ros tyrosine kinase receptor may provide a signal transduction pathway for epithelial-mesenchymal interactions [7].
  • The temporal and spatial arrangement of c-ros transcripts is coincident with the phenotypic induction and proliferation of epithelium during organogenesis of the kidney and intestine [7].
 

Anatomical context of Ros1

 

Associations of Ros1 with chemical compounds

  • Development of the caput epididymidis studied by expressed proteins (a glutamate transporter, a lipocalin and beta-galactosidase) in the c-ros knockout and wild-type mice with prepubertally ligated efferent ducts [12].
  • Transgenic mice targeted for the c-ros gene, which are fertile when heterozygous (HET), but infertile when homozygous (knockout, KO) and associated with failure in pubertal differentiation of the epididymal initial segment, provide a model for studying the role of the epididymal luminal environment in sperm development [13].
  • Thus, caput region I develops before c-ros expression, high testosterone secretion and differentiation of regions II and III but not if the organ is deprived of the oncogene c-ros or testicular exocrine secretions [12].
  • Comparative role of phosphotyrosine kinase domains of c-ros and c-ret protooncogenes in metanephric development with respect to growth factors and matrix morphogens [14].
  • Expression and location of taurine transporters and channels in the epididymis of infertile c-ros receptor tyrosine kinase-deficient and fertile heterozygous mice [15].
 

Other interactions of Ros1

 

Analytical, diagnostic and therapeutic context of Ros1

  • Competitive RT-PCR analyses revealed the c-ros expression was the highest at 13th day of gestation, and it declined to very low levels during the neonatal period [18].
  • Analysis by cDNA microarrays showed that in the murine epididymis, NaPi-IIb was the predominantly expressed epithelial isoform of the sodium-inorganic phosphate cotransporter and was markedly overexpressed in the proximal region in the infertile knockout (KO) compared to the fertile heterozygous (HET) c-ros transgenic mouse [19].
  • The role of various receptor-like protooncogenes, with the emphasis on c-ros and c-ret, was investigated by antisense-oligodeoxynucleotide (ODN) gene-targeting strategies at a point in metanephric development when reciprocal-inductive interactions between the epithelium and mesenchyme have already been initiated and are rampant [14].
  • Real-time PCR analysis showed that c-ros mRNA is expressed all along the human epididymis with the exception of the proximal caput epididymidis, where c-ros transcript was undetectable [20].

References

  1. The human c-ros gene (ROS) is located at chromosome region 6q16----6q22. Nagarajan, L., Louie, E., Tsujimoto, Y., Balduzzi, P.C., Huebner, K., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. The cause of infertility of male c-ros tyrosine kinase receptor knockout mice. Yeung, C.H., Wagenfeld, A., Nieschlag, E., Cooper, T.G. Biol. Reprod. (2000) [Pubmed]
  3. Mouse models of infertility due to swollen spermatozoa. Cooper, T.G., Yeung, C.H., Wagenfeld, A., Nieschlag, E., Poutanen, M., Huhtaniemi, I., Sipilä, P. Mol. Cell. Endocrinol. (2004) [Pubmed]
  4. Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas. Bonner, A.E., Lemon, W.J., Devereux, T.R., Lubet, R.A., You, M. Oncogene (2004) [Pubmed]
  5. The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Sonnenberg-Riethmacher, E., Walter, B., Riethmacher, D., Gödecke, S., Birchmeier, C. Genes Dev. (1996) [Pubmed]
  6. Lack of glutamate transporter EAAC1 in the epididymis of infertile c-ros receptor tyrosine-kinase deficient mice. Wagenfeld, A., Yeung, C.H., Lehnert, W., Nieschlag, E., Cooper, T.G. J. Androl. (2002) [Pubmed]
  7. c-ros: the vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse embryonic development. Tessarollo, L., Nagarajan, L., Parada, L.F. Development (1992) [Pubmed]
  8. Gene and protein expression in the epididymis of infertile c-ros receptor tyrosine kinase-deficient mice. Cooper, T.G., Wagenfeld, A., Cornwall, G.A., Hsia, N., Chu, S.T., Orgebin-Crist, M.C., Drevet, J., Vernet, P., Avram, C., Nieschlag, E., Yeung, C.H. Biol. Reprod. (2003) [Pubmed]
  9. Lipid diffusion in the plasma membrane of mouse spermatozoa: changes during epididymal maturation, effects of pH, osmotic pressure, and knockout of the c-ros gene. Christova, Y., James, P.S., Cooper, T.G., Jones, R. J. Androl. (2002) [Pubmed]
  10. Regulation of the initial segment of the murine epididymis by dihydrotestosterone and testicular exocrine secretions studied by expression of specific proteins and gene expression. Avram, C., Yeung, C.H., Nieschlag, E., Cooper, T.G. Cell Tissue Res. (2004) [Pubmed]
  11. Differential expression of neurotrophin receptors during renal development. Durbeej, M., Söderström, S., Ebendal, T., Birchmeier, C., Ekblom, P. Development (1993) [Pubmed]
  12. Development of the caput epididymidis studied by expressed proteins (a glutamate transporter, a lipocalin and beta-galactosidase) in the c-ros knockout and wild-type mice with prepubertally ligated efferent ducts. Avram, C.E., Cooper, T.G. Cell Tissue Res. (2004) [Pubmed]
  13. Increased luminal pH in the epididymis of infertile c-ros knockout mice and the expression of sodium-hydrogen exchangers and vacuolar proton pump H+-ATPase. Yeung, C.H., Breton, S., Setiawan, I., Xu, Y., Lang, F., Cooper, T.G. Mol. Reprod. Dev. (2004) [Pubmed]
  14. Comparative role of phosphotyrosine kinase domains of c-ros and c-ret protooncogenes in metanephric development with respect to growth factors and matrix morphogens. Liu, Z.Z., Wada, J., Kumar, A., Carone, F.A., Takahashi, M., Kanwar, Y.S. Dev. Biol. (1996) [Pubmed]
  15. Expression and location of taurine transporters and channels in the epididymis of infertile c-ros receptor tyrosine kinase-deficient and fertile heterozygous mice. Xu, Y.X., Wagenfeld, A., Yeung, C.H., Lehnert, W., Cooper, T.G. Mol. Reprod. Dev. (2003) [Pubmed]
  16. Localization of the mouse kidney disease (kd) gene to a YAC/BAC contig on Chromosome 10. Dell, K.M., Li, Y.X., Peng, M., Neilson, E.G., Gasser, D.L. Mamm. Genome (2000) [Pubmed]
  17. A high-resolution genetic map around waltzer on mouse chromosome 10 and identification of a new allele of waltzer. Bryda, E.C., Ling, H., Flaherty, L. Mamm. Genome (1997) [Pubmed]
  18. Cloning of mouse c-ros renal cDNA, its role in development and relationship to extracellular matrix glycoproteins. Kanwar, Y.S., Liu, Z.Z., Kumar, A., Wada, J., Carone, F.A. Kidney Int. (1995) [Pubmed]
  19. Sodium-inorganic phosphate cotransporter NaPi-IIb in the epididymis and its potential role in male fertility studied in a transgenic mouse model. Xu, Y., Yeung, C.H., Setiawan, I., Avram, C., Biber, J., Wagenfeld, A., Lang, F., Cooper, T.G. Biol. Reprod. (2003) [Pubmed]
  20. Expression and localization of c-ros oncogene along the human excurrent duct. Légaré, C., Sullivan, R. Mol. Hum. Reprod. (2004) [Pubmed]
 
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