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Gene Review

P2ry2  -  purinergic receptor P2Y, G-protein coupled, 2

Rattus norvegicus

Synonyms: ATP receptor, P2U purinoceptor 1, P2U1, P2Y purinoceptor 2, P2Y2, ...
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Disease relevance of P2ry2

  • These data showing a strong expression of the P2Y2 purinoceptor in the neointima of injured arteries suggest that extracellular nucleotides may be involved, via this receptor, in the intimal hyperplasia and/or chronic constriction observed at the lesion site, and consequently in the restenotic process [1].
  • The deduced 374-amino acid product shows structural features common to other G protein-coupled receptors, and when stably transfected into a glioma cell line lacking endogenous ATP receptors, is functionally characterized as a P2U purinoceptor [2].
  • The putative protein demonstrated > 97% homology with the P2u-purinoceptor previously identified in the hybrid neuroblastoma x glioma cell line, NG 108-15, 87% homology to the recently cloned human P2u-purinoceptor, and 34% homology to the P2u-purinoceptor cloned from chicken brain [3].
  • After stab wound injury the additional expression of the P2Y2 and P2Y6 receptors, and an up-regulation of the P2Y1,4 receptor-labeling on astrocytic cell bodies and/or processes was observed [4].
  • This suggests P2Y2/4 receptors simultaneously couple to pertussis toxin-sensitive and -resistant G proteins whilst P2Y1 receptors couple to only the toxin-resistant proteins [5].

High impact information on P2ry2

  • We studied mechanically induced calcium waves in two rat osteosarcoma cell lines that differ in the gap junction proteins they express, in their ability to pass microinjected dye from cell to cell, and in their expression of P2Y2 (P2U) purinergic receptors [6].
  • In addition to confirming the presence of classical P2Y2 receptors, these results also provide functional evidence for the existence of a novel UDP receptor in pulmonary arterial myocytes, which may contribute to pyrimidine-evoked vasoconstriction [7].
  • These results show the existence of P2x and P2U purinoceptor subtypes in pulmonary arterial smooth muscle cells [8].
  • The rank order of agonist preference, UTP>ATP>ATPgammaS, suggests that the effects of extracellular ATP is mediated through the activation of P2Y2 receptors in hepatocytes [9].
  • The P2Y2 receptor is a uridine/adenosine triphosphate (UTP/ATP)-sensitive G-protein-linked nucleotide receptor that previously has been reported to stimulate the phosphoinositide signaling pathway [10].

Chemical compound and disease context of P2ry2


Biological context of P2ry2


Anatomical context of P2ry2


Associations of P2ry2 with chemical compounds

  • The former effect was mimicked by a P2X3 agonist, alpha,beta-methylene ATP, at 10(-5) M, while the latter was mimicked by 2-methylthio ADP (a P2Y1 agonist) or UTP (a P2Y2 agonist) at 10(-3) M, suggesting that the former is mediated by P2X receptors and the latter by P2Y receptors [17].
  • Moreover, a subpopulation of neointimal cells localized at the luminal surface could be identified by a higher P2Y2 expression than the underlying neointimal smooth muscle cells [1].
  • P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function [18].
  • Acetylcholine induced vasodilatation. alpha,beta-meATP, 2-MeSADP, and UTP induced vasoconstriction via P2X1, P2Y1, and P2Y2 receptors, respectively [19].
  • Suramin, an antagonist that blocks P2Y2 receptors, partly inhibited ATP- and UTP-induced contractions of veins [20].

Regulatory relationships of P2ry2

  • In contrast, stimulation of P2Y2 receptors led to a 20% inhibition of co-expressed BK channel activity, a response that was sensitive to TEA [21].
  • Thus SPOC1 cells secrete mucin under the control of a P2u purinoceptor; they should prove useful in dissecting the associated cellular regulatory pathways [22].

Other interactions of P2ry2

  • We are the first to describe the expression of P2X4 receptors on thymocytes and confirm the finding of P2X1 and P2Y2 receptors on subpopulations of lymphocytes [23].
  • The characteristics of the U and A receptors were consistent with those of P2Y2 and P2X2, respectively, and their distribution in the different AP cell types was not homogeneous [24].
  • P2Y2 receptor mRNA and protein expression is altered in inner medullas of hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function [25].
  • P2X4, P2Y1 and P2Y2 receptors on rat alveolar macrophages [26].
  • By use of a peptide kinase assay, UTP gave a substantial increase in MAPK activity with a concentration-dependency consistent with activation at P2Y2 receptors [27].

Analytical, diagnostic and therapeutic context of P2ry2


  1. Overexpression of P2Y2 purinoceptor in intimal lesions of the rat aorta. Seye, C.I., Gadeau, A.P., Daret, D., Dupuch, F., Alzieu, P., Capron, L., Desgranges, C. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  2. Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor. Chen, Z.P., Krull, N., Xu, S., Levy, A., Lightman, S.L. Endocrinology (1996) [Pubmed]
  3. Cloning and expression of the alveolar type II cell P2u-purinergic receptor. Rice, W.R., Burton, F.M., Fiedeldey, D.T. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  4. P2Y receptor expression on astrocytes in the nucleus accumbens of rats. Franke, H., Krügel, U., Grosche, J., Heine, C., Härtig, W., Allgaier, C., Illes, P. Neuroscience (2004) [Pubmed]
  5. P2Y receptor-mediated Ca2+ signalling in cultured rat aortic smooth muscle cells. Pediani, J.D., McGrath, J.C., Wilson, S.M. Br. J. Pharmacol. (1999) [Pubmed]
  6. ATP- and gap junction-dependent intercellular calcium signaling in osteoblastic cells. Jorgensen, N.R., Geist, S.T., Civitelli, R., Steinberg, T.H. J. Cell Biol. (1997) [Pubmed]
  7. Functional evidence for a novel suramin-insensitive pyrimidine receptor in rat small pulmonary arteries. Hartley, S.A., Kato, K., Salter, K.J., Kozlowski, R.Z. Circ. Res. (1998) [Pubmed]
  8. Electrophysiological consequences of purinergic receptor stimulation in isolated rat pulmonary arterial myocytes. Hartley, S.A., Kozlowski, R.Z. Circ. Res. (1997) [Pubmed]
  9. Extracellular ATP activates c-jun N-terminal kinase signaling and cell cycle progression in hepatocytes. Thevananther, S., Sun, H., Li, D., Arjunan, V., Awad, S.S., Wyllie, S., Zimmerman, T.L., Goss, J.A., Karpen, S.J. Hepatology (2004) [Pubmed]
  10. P2Y2 nucleotide receptors expressed heterologously in sympathetic neurons inhibit both N-type Ca2+ and M-type K+ currents. Filippov, A.K., Webb, T.E., Barnard, E.A., Brown, D.A. J. Neurosci. (1998) [Pubmed]
  11. P2 purinoceptor-mediated dilations in the rat middle cerebral artery after ischemia-reperfusion. Marrelli, S.P., Khorovets, A., Johnson, T.D., Childres, W.F., Bryan, R.M. Am. J. Physiol. (1999) [Pubmed]
  12. Short-term hyperthyroidism modulates adenosine receptors and catalytic activity of adenylate cyclase in adipocytes. Rapiejko, P.J., Malbon, C.C. Biochem. J. (1987) [Pubmed]
  13. P2Y2 receptor activation regulates the expression of acetylcholinesterase and acetylcholine receptor genes at vertebrate neuromuscular junctions. Tung, E.K., Choi, R.C., Siow, N.L., Jiang, J.X., Ling, K.K., Simon, J., Barnard, E.A., Tsim, K.W. Mol. Pharmacol. (2004) [Pubmed]
  14. ATP and UTP at low concentrations strongly inhibit bone formation by osteoblasts: a novel role for the P2Y2 receptor in bone remodeling. Hoebertz, A., Mahendran, S., Burnstock, G., Arnett, T.R. J. Cell. Biochem. (2002) [Pubmed]
  15. Purinergic signalling to rat ovarian smooth muscle: changes in P2X receptor expression during pregnancy. Katugampola, H., Burnstock, G. Cells Tissues Organs (Print) (2004) [Pubmed]
  16. The pattern of distribution of selected ATP-sensitive P2 receptor subtypes in normal rat kidney: an immunohistological study. Turner, C.M., Vonend, O., Chan, C., Burnstock, G., Unwin, R.J. Cells Tissues Organs (Print) (2003) [Pubmed]
  17. Inhibitory, facilitatory, and excitatory effects of ATP and purinergic receptor agonists on the activity of rat cutaneous nociceptors in vitro. Yajima, H., Sato, J., Giron, R., Nakamura, R., Mizumura, K. Neurosci. Res. (2005) [Pubmed]
  18. P2Y2 receptor-mediated release of prostaglandin E2 by IMCD is altered in hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Sun, R., Carlson, N.G., Hemmert, A.C., Kishore, B.K. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  19. Unusual absence of endothelium-dependent or -independent vasodilatation to purines or pyrimidines in the rat renal artery. Knight, G.E., Oliver-Redgate, R., Burnstock, G. Kidney Int. (2003) [Pubmed]
  20. Differential localization of P2 receptor subtypes in mesenteric arteries and veins of normotensive and hypertensive rats. Galligan, J.J., Hess, M.C., Miller, S.B., Fink, G.D. J. Pharmacol. Exp. Ther. (2001) [Pubmed]
  21. P2Y2 and P2Y4 receptors regulate pancreatic Ca(2+)-activated K+ channels differently. Hede, S.E., Amstrup, J., Klaerke, D.A., Novak, I. Pflugers Arch. (2005) [Pubmed]
  22. P2u purinoceptor regulation of mucin secretion in SPOC1 cells, a goblet cell line from the airways. Abdullah, L.H., Davis, S.W., Burch, L., Yamauchi, M., Randell, S.H., Nettesheim, P., Davis, C.W. Biochem. J. (1996) [Pubmed]
  23. P2 receptors in the thymus: expression of P2X and P2Y receptors in adult rats, an immunohistochemical and in situ hybridisation study. Glass, R., Townsend-Nicholson, A., Burnstock, G. Cell Tissue Res. (2000) [Pubmed]
  24. Functional ATP receptors in rat anterior pituitary cells. Villalobos, C., Alonso-Torre, S.R., Núñez, L., García-Sancho, J. Am. J. Physiol. (1997) [Pubmed]
  25. P2Y2 receptor mRNA and protein expression is altered in inner medullas of hydrated and dehydrated rats: relevance to AVP-independent regulation of IMCD function. Kishore, B.K., Krane, C.M., Miller, R.L., Shi, H., Zhang, P., Hemmert, A., Sun, R., Nelson, R.D. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  26. P2X4, P2Y1 and P2Y2 receptors on rat alveolar macrophages. Bowler, J.W., Bailey, R.J., North, R.A., Surprenant, A. Br. J. Pharmacol. (2003) [Pubmed]
  27. Regulation of brain capillary endothelial cells by P2Y receptors coupled to Ca2+, phospholipase C and mitogen-activated protein kinase. Albert, J.L., Boyle, J.P., Roberts, J.A., Challiss, R.A., Gubby, S.E., Boarder, M.R. Br. J. Pharmacol. (1997) [Pubmed]
  28. P2Y6 nucleotide receptors activate NF-kappaB and increase survival of osteoclasts. Korcok, J., Raimundo, L.N., Du, X., Sims, S.M., Dixon, S.J. J. Biol. Chem. (2005) [Pubmed]
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