Disease relevance of LOC396454

• Finally, purpurin supports the survival of dissociated ciliary ganglion cells, indicating that RBPs can act as ciliary neurotrophic factors [1].

High impact information on LOC396454

• Purpurin binds retinol and may play a major role in retinol transport across the interphotoreceptor cell matrix [2].
• A cDNA for purpurin, a secreted 20,000 dalton neural retina cell adhesion and survival protein, has been sequenced and expressed in mammalian cells [2].
• The predicted purpurin sequence contains 196 residues, has approximately 50% sequence homology with serum retinol binding protein, and is a member of the alpha-2 mu-globulin superfamily [2].
• Purpurin is a constituent of adherons and promotes cell-adheron adhesion by interacting with a cell surface heparan sulfate proteoglycan [1].
• A mini-gene encoding rat retinol-binding protein (RBP) and a cDNA encoding chicken purpurin were separately transfected into HeLa cells [3].

Biological context of LOC396454

• The distribution of CLL-I binding sites in intestine were mimicked by those of purpurin, another lactose-binding lectin [4].

Anatomical context of LOC396454

• Furthermore, the action of retinol-bound purpurin was effective only in the control (untreated) retinas but not in those primed (treated) with a previous optic nerve transection [5].
• Role of purpurin as a retinol-binding protein in goldfish retina during the early stage of optic nerve regeneration: its priming action on neurite outgrowth [5].
• Purpurin mRNA was localized to the photoreceptor cells, whereas the protein was diffusely found in all of the retinal layers [5].

Associations of LOC396454 with chemical compounds

• On the other hand, two other anthraquinone derivatives, chrysophanic acid and purpurin, which inhibit PKA activity, at doses of 0.25 and 0.5 ng/chick also yielded retention deficits [6].
• The most suitable compounds for forming fluorescent Al chelates were 8-hydroxyquinoline, morin, nuclear fast red and purpurin [7].

Other interactions of LOC396454

• Monospecific antibodies to purpurin and a heparan sulphate proteoglycan (HSPG), two components of adherons, labeled a subpopulation of junctions [8].

Analytical, diagnostic and therapeutic context of LOC396454

• Levels of purpurin mRNA and protein transiently increased and rapidly decreased 2-5 d and 10 d after axotomy, respectively [5].

References