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Gene Review

LOC396454  -  purpurin

Gallus gallus

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Disease relevance of LOC396454

  • Finally, purpurin supports the survival of dissociated ciliary ganglion cells, indicating that RBPs can act as ciliary neurotrophic factors [1].

High impact information on LOC396454

  • Purpurin binds retinol and may play a major role in retinol transport across the interphotoreceptor cell matrix [2].
  • A cDNA for purpurin, a secreted 20,000 dalton neural retina cell adhesion and survival protein, has been sequenced and expressed in mammalian cells [2].
  • The predicted purpurin sequence contains 196 residues, has approximately 50% sequence homology with serum retinol binding protein, and is a member of the alpha-2 mu-globulin superfamily [2].
  • Purpurin is a constituent of adherons and promotes cell-adheron adhesion by interacting with a cell surface heparan sulfate proteoglycan [1].
  • A mini-gene encoding rat retinol-binding protein (RBP) and a cDNA encoding chicken purpurin were separately transfected into HeLa cells [3].

Biological context of LOC396454


Anatomical context of LOC396454

  • Furthermore, the action of retinol-bound purpurin was effective only in the control (untreated) retinas but not in those primed (treated) with a previous optic nerve transection [5].
  • Role of purpurin as a retinol-binding protein in goldfish retina during the early stage of optic nerve regeneration: its priming action on neurite outgrowth [5].
  • Purpurin mRNA was localized to the photoreceptor cells, whereas the protein was diffusely found in all of the retinal layers [5].

Associations of LOC396454 with chemical compounds


Other interactions of LOC396454

  • Monospecific antibodies to purpurin and a heparan sulphate proteoglycan (HSPG), two components of adherons, labeled a subpopulation of junctions [8].

Analytical, diagnostic and therapeutic context of LOC396454

  • Levels of purpurin mRNA and protein transiently increased and rapidly decreased 2-5 d and 10 d after axotomy, respectively [5].


  1. A chick neural retina adhesion and survival molecule is a retinol-binding protein. Schubert, D., LaCorbiere, M., Esch, F. J. Cell Biol. (1986) [Pubmed]
  2. Sequence analysis, cellular localization, and expression of a neuroretina adhesion and cell survival molecule. Berman, P., Gray, P., Chen, E., Keyser, K., Ehrlich, D., Karten, H., LaCorbiere, M., Esch, F., Schubert, D. Cell (1987) [Pubmed]
  3. A genetically engineered purpurin/retinol-binding protein hybrid that binds to transthyretin. Melhus, H., Rask, L. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  4. Chicken tissue binding sites for a purified chicken lectin. Beyer, E.C., Barondes, S.H. J. Supramol. Struct. (1980) [Pubmed]
  5. Role of purpurin as a retinol-binding protein in goldfish retina during the early stage of optic nerve regeneration: its priming action on neurite outgrowth. Matsukawa, T., Sugitani, K., Mawatari, K., Koriyama, Y., Liu, Z., Tanaka, M., Kato, S. J. Neurosci. (2004) [Pubmed]
  6. Inhibitors of cAMP-dependent protein kinase impair long-term memory formation in day-old chicks. Zhao, W.Q., Polya, G.M., Wang, B.H., Gibbs, M.E., Sedman, G.L., Ng, K.T. Neurobiology of learning and memory. (1995) [Pubmed]
  7. New fluorescence reactions in DNA cytochemistry. 2. Microscopic and spectroscopic studies on fluorescent aluminum complexes. Del Castillo, P., Llorente, A.R., Gómez, A., Gosálvez, J., Goyanes, V.J., Stockert, J.C. Anal. Quant. Cytol. Histol. (1990) [Pubmed]
  8. Biochemical differentiation of nascent neurite junctions: unilateral localization of adheron components. Tsui, H.C., Klein, W.L. Brain Res. Dev. Brain Res. (1990) [Pubmed]
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