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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

SP-D  -  surfactant protein D

Sus scrofa

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Disease relevance of SP-D


High impact information on SP-D

  • Platelet aggregation in response to collagen was reduced in most SPD pigs [2].
  • While the initial uptake of 14C-labeled serotonin into platelets was similar in SPD and normal pigs, retention of serotonin was reduced in platelets of SPD pigs [2].
  • The difference in mass is due to the presence of an Asparagine-linked glycosylation in the carbohydrate recognition domain of porcine SP-D, which is absent in SP-D of other species investigated so far [3].
  • Our present aim was to establish the sites of SP-A and SP-D expression within the epithelium of the ET in vivo [4].
  • Recently, we described the expression of SP-A and SP-D in the ET, suggesting their role in middle ear host defense [5].

Biological context of SP-D


Anatomical context of SP-D


Other interactions of SP-D


Analytical, diagnostic and therapeutic context of SP-D


  1. Interactions of influenza A virus with sialic acids present on porcine surfactant protein D. van Eijk, M., White, M.R., Batenburg, J.J., Vaandrager, A.B., van Golde, L.M., Haagsman, H.P., Hartshorn, K.L. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  2. Platelet storage pool deficiency in pigs. Daniels, T.M., Fass, D.N., White, J.G., Bowie, E.J. Blood (1986) [Pubmed]
  3. Porcine surfactant protein D is N-glycosylated in its carbohydrate recognition domain and is assembled into differently charged oligomers. van Eijk, M., van de Lest, C.H., Batenburg, J.J., Vaandrager, A.B., Meschi, J., Hartshorn, K.L., van Golde, L.M., Haagsman, H.P. Am. J. Respir. Cell Mol. Biol. (2002) [Pubmed]
  4. Surfactant proteins A and D in Eustachian tube epithelium. Paananen, R., Sormunen, R., Glumoff, V., van Eijk, M., Hallman, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  5. Expression and localization of lung surfactant protein B in Eustachian tube epithelium. Paananen, R., Glumoff, V., Sormunen, R., Voorhout, W., Hallman, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  6. Purification, characterization and immunolocalization of porcine surfactant protein D. Soerensen, C.M., Nielsen, O.L., Willis, A., Heegaard, P.M., Holmskov, U. Immunology (2005) [Pubmed]
  7. Assignment of surfactant protein A (SFTPA) and surfactant protein D (SFTPD) to pig chromosome band 14q25-->q26 by in situ hybridization. van Eijk, M., de Haan, N.A., Rogel-Gaillard, C., Zijlstra, C., Lawson, P.R., Bosma, A.A. Cytogenet. Cell Genet. (2001) [Pubmed]
  8. Pulmonary infections in swine induce altered porcine surfactant protein D expression and localization to dendritic cells in bronchial-associated lymphoid tissue. Soerensen, C.M., Holmskov, U., Aalbaek, B., Boye, M., Heegaard, P.M., Nielsen, O.L. Immunology (2005) [Pubmed]
  9. Plasma C3d levels of young farmers correlate with respirable dust exposure levels during normal work in swine confinement buildings. Hoffmann, H.J., Iversen, M., Brandslund, I., Sigsgaard, T., Omland, Ø., Oxvig, C., Holmskov, U., Bjermer, L., Jensenius, J.C., Dahl, R. Annals of agricultural and environmental medicine : AAEM. (2003) [Pubmed]
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