The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ugt1a6a  -  UDP glucuronosyltransferase 1 family,...

Mus musculus

Synonyms: Phenol UDP-glucuronosyltransferase, UDP-glucuronosyltransferase 1-6, UDP-glucuronosyltransferase 1A6, UDPGT, UDPGT 1-6, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Ugt1a6a


Biological context of Ugt1a6a


Anatomical context of Ugt1a6a


Associations of Ugt1a6a with chemical compounds

  • We also detected duplication of the gene for phenol UDPGT in all mouse strains examined with the exception of MOL-MIT and SUB-SHH [5].
  • The enzyme expressed stably in V79 cells predominantly catalyzed the glucuronidation of simple, planar phenols (e.g., for 1-naphthol, K(m) = 41 microM, V(max) = 0.07 nmol/min/mg protein), a class of compounds extensively glucuronidated by human UGT1A6 [6].
  • Induction of UGT1A6 is thought to be responsible at least partly for reduced serum thyroid hormone levels in TCDD-exposed mice [9].

Other interactions of Ugt1a6a

  • In liver plus nine extrahepatic tissues of untreated newborn 14CoS/14CoS mutant and ch/ch wild-type mice, we compared NMO1, UGT1A6, AHD3 and HNF-1 alpha mRNA levels [4].
  • Male-predominant expression was observed for Ugt2b1 in liver, Ugt2b5/37/38 in kidney, and Ugt1a6 in lung [10].
  • PhSCA also increased GstP, and PhOHSCA increased Ugt1a1 and Ugt1a6 levels [11].
  • P-450 content and the UDPGT activity were significantly elevated (p < 0.01-0.001) from the early stages of tumor growth while the cytosolic GSHT activity reached its highest level (p < 0.01-0.001) only 10 days after tumor transplantation [12].

Analytical, diagnostic and therapeutic context of Ugt1a6a

  • However, when New Zealand white rabbits were treated with TCDD and liver mRNA was examined by Northern blot analysis, it was shown that TCDD had no effect on the induction of UGT1.6 mRNA.(ABSTRACT TRUNCATED AT 250 WORDS)[1]


  1. Cloning and characterization of cDNAs encoding mouse Ugt1.6 and rabbit UGT1.6: differential induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Lamb, J.G., Straub, P., Tukey, R.H. Biochemistry (1994) [Pubmed]
  2. Phase II metabolism of benzene. Schrenk, D., Orzechowski, A., Schwarz, L.R., Snyder, R., Burchell, B., Ingelman-Sundberg, M., Bock, K.W. Environ. Health Perspect. (1996) [Pubmed]
  3. The effect of malaria infection on 3'-azido-3'-deoxythymidine and paracetamol glucuronidation in rat liver microsomes. Ismail, S., Back, D.J., Edwards, G. Biochem. Pharmacol. (1992) [Pubmed]
  4. Extrahepatic expression of NAD(P)H:menadione oxidoreductase, UDP glucuronosyltransferase-1A6, microsomal aldehyde dehydrogenase, and hepatic nuclear factor-1 alpha mRNAs in ch/ch and 14CoS/14CoS mice. Vasiliou, V., Reuter, S.F., Nebert, D.W. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  5. Isolation of cDNAs for mouse phenol and bilirubin UDP-glucuronosyltransferases and mapping of the mouse gene for phenol UDP-glucuronosyltransferase (Ugtla1) to chromosome 1 by restriction fragment length variations. Koiwai, O., Hasada, K., Yasui, Y., Sakai, Y., Sato, H., Watanabe, T. Biochem. Genet. (1995) [Pubmed]
  6. Cloning and characterization of a canine UDP-glucuronosyltransferase. Soars, M.G., Smith, D.J., Riley, R.J., Burchell, B. Arch. Biochem. Biophys. (2001) [Pubmed]
  7. Differential regulation of alternate UDP-glucuronosyltransferase 1A6 gene promoters by hepatic nuclear factor-1. Auyeung, D.J., Kessler, F.K., Ritter, J.K. Toxicol. Appl. Pharmacol. (2003) [Pubmed]
  8. Modulation of cytochrome P450 and phase II enzymes by protocatechuic acid in mouse liver and kidney. Krajka-Kuźniak, V., Szaefer, H., Baer-Dubowska, W. Toxicology (2005) [Pubmed]
  9. Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice. Nishimura, N., Yonemoto, J., Miyabara, Y., Fujii-Kuriyama, Y., Tohyama, C. Arch. Toxicol. (2005) [Pubmed]
  10. Tissue- and Gender-Specific mRNA Expression of UDP-Glucuronosyltransferases (UGTs) in Mice. Buckley, D.B., Klaassen, C.D. Drug Metab. Dispos. (2007) [Pubmed]
  11. Acute effects of novel selenazolidines on murine chemoprotective enzymes. El-Sayed, W., Aboul-Fadl, T., Lamb, J.G., Roberts, J.C., Franklin, M.R. Chem. Biol. Interact. (2006) [Pubmed]
  12. Comparative patterns of hepatic drug metabolizing enzymes and their possible correlation with chromosomal aberrations in transplantable murine lymphoma: a time course study. Sarkar, A., Mukherjee, B., Rana, M., Chatterjee, M. Cancer Invest. (1994) [Pubmed]
WikiGenes - Universities