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Gene Review

EGR1  -  early growth response 1

Bos taurus

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High impact information on EGR1

  • Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2 [1].
  • Studies of EGR-1 regulation in primary granulosa cells cultured with forskolin showed that levels of EGR-1 mRNA were low at 0 h, highly increased at 6 h post-forskolin (P < 0.05), and declined to steady state thereafter [2].
  • The objective of this study was to characterize gonadotropin-dependent regulation of bovine EGR-1 in preovulatory follicles prior to ovulation [2].
  • High levels of the EGR-1 mRNA were also observed in corpus luteum, uterus, kidney, pituitary, and spleen, moderate and low in other bovine tissues tested [2].
  • Interestingly, overexpression of EGR-1 increased the levels of mRNA for prostaglandin (PG) G/H synthase-2 (PGHS-2), PG E synthase (PGES), PG E2 receptor (EP2), LH receptor (LH-R), but not for cytochrome P450-side chain cleavage (P450scc), and cytochrome P450 aromatase (P450arom) in granulosa cultures [2].

Associations of EGR1 with chemical compounds

  • These studies demonstrate that PGF2alpha stimulates the expression of EGR1 and TGFB1 in the CL [3].

Biological context of EGR1


Anatomical context of EGR1

  • Analyses performed on isolated preparations of granulosa and theca cells indicated that EGR-1 mRNA was regulated in both cell types, with a predominant expression in granulosa cells [2].

Analytical, diagnostic and therapeutic context of EGR1


  1. Early growth response factor-1 induction by injury is triggered by release and paracrine activation by fibroblast growth factor-2. Santiago, F.S., Lowe, H.C., Day, F.L., Chesterman, C.N., Khachigian, L.M. Am. J. Pathol. (1999) [Pubmed]
  2. Characterization of bovine early growth response factor-1 and its gonadotropin-dependent regulation in ovarian follicles prior to ovulation. Sayasith, K., Brown, K.A., Lussier, J.G., Dor??, M., Sirois, J. J. Mol. Endocrinol. (2006) [Pubmed]
  3. Prostaglandin F2alpha stimulates the expression and secretion of transforming growth factor B1 via induction of the early growth response 1 gene (EGR1) in the bovine corpus luteum. Hou, X., Arvisais, E.W., Jiang, C., Chen, D.B., Roy, S.K., Pate, J.L., Hansen, T.R., Rueda, B.R., Davis, J.S. Mol. Endocrinol. (2008) [Pubmed]
  4. Endothelial gene regulation by laminar shear stress. Resnick, N., Yahav, H., Khachigian, L.M., Collins, T., Anderson, K.R., Dewey, F.C., Gimbrone, M.A. Adv. Exp. Med. Biol. (1997) [Pubmed]
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