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Gene Review:

GRIN1 - glutamate receptor, ionotropic, N-methyl D...

Ovis aries

Jiang, H. et al., El-Haddad, M.A. et al., Dean, J.M. et al., Yan, E. et al., Dean, J.M. et al., et al.

McGowan, Sysyn, Petersson, Sadowska, Mishra, Delivoria-Papadopoulos, Stonestreet,

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Disease relevance of NMDAR1

We concluded that NMDA-induced focal brain injury and associated hyperemia in the newborn lamb appear to be specific NMDA receptor-mediated events [1].
In conclusion, the present studies suggest that in the immature brain the initial phase of delayed cerebral and peripheral hypoperfusion following exposure to severe hypoxia is mediated by NMDA receptor activity [2].

Psychiatry related information on NMDAR1

BACKGROUND: In adult rats, N-methyl-D-aspartate (NMDA) receptors have been implicated in the central control of body fluid homeostasis, as intracerebroventricular (ICV) injection of NMDA receptor antagonists suppresses stimulated drinking behavior [3].

High impact information on NMDAR1

We therefore examined an infusion of the specific, non-competitive NMDA receptor antagonist dizocilpine (2 mg kg(-1) bolus plus 0.07 mg kg(-1) h(-1) i.v.) from 15 min to 4 h after severe hypoxia-ischemia induced by umbilical cord occlusion for 25 min in fetal sheep at 70% of gestation [4].
In high concentrations or after prolonged exposure, the N-methyl-D-aspartate receptor agonist quinolinic acid (QUIN) induces lipid peroxidation, oxidative stress, and cell death in the adult brain, and after i.c.v. injection induces seizures and increases blood-brain barrier permeability [5].
To determine whether endogenous glutamate and aspartate control LH secretion via N-methyl-D-aspartate (NMDA) receptors in the sheep, we evaluated the effects of the NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid (AP5) on secretion of LH in ovariectomized lambs [6].
The specific, non-competitive NMDA receptor antagonist dizocilpine maleate (2 mg kg-1 bolus plus 0.07 mg kg h-1i.v.) or saline (vehicle) was infused from 15 min after asphyxia until 4 h [2].
The neuroendocrine role of endogenous ligands for the excitatory amino acid receptor subtype known as the NMDA receptor was investigated by administering the NMDA receptor antagonist MK-801 to ovariectomized (ovx) and estradiol-treated sheep [7].

Anatomical context of NMDAR1

We speculate that reduced NMDA receptor expression within the forebrain dipsogenic neurons may account for observed differences in drinking activities between the fetus/neonate and the adult [3].

Associations of NMDAR1 with chemical compounds

In summary, antagonizing the endogenous excitatory amino acid ligands of the NMDA receptor with MK-801 did not alter either the timing or magnitude of the putative episodic discharges of gonadotropin-releasing hormone (GnRH) which in turn cause the episodic releases of pituitary LH in ovx sheep [7].
Thus, dexamethasone treatment appears to modify the NMDA receptor only during a specific period of brain development [8].

References

Experimental neuronal injury in the newborn lamb: a comparison of N-methyl-D-aspartic acid receptor blockade and nitric oxide synthesis inhibition on lesion size and cerebral hyperemia. Taylor, G.A., Trescher, W.H., Johnston, M.V., Traystman, R.J. Pediatr. Res. (1995) [Pubmed]
Transient NMDA receptor-mediated hypoperfusion following umbilical cord occlusion in preterm fetal sheep. Dean, J.M., Gunn, A.J., Wassink, G., Bennet, L. Exp. Physiol. (2006) [Pubmed]
N-methyl-D-aspartate glutamate receptor mediates spontaneous and angiotensin II-stimulated ovine fetal swallowing. El-Haddad, M.A., Chao, C.R., Ross, M.G. J. Soc. Gynecol. Investig. (2005) [Pubmed]
Suppression of post-hypoxic-ischemic EEG transients with dizocilpine is associated with partial striatal protection in the preterm fetal sheep. Dean, J.M., George, S.A., Wassink, G., Gunn, A.J., Bennet, L. Neuropharmacology (2006) [Pubmed]
Quinolinic acid promotes albumin deposition in Purkinje cell, astrocytic activation and lipid peroxidation in fetal brain. Yan, E., Castillo-Meléndez, M., Smythe, G., Walker, D. Neuroscience (2005) [Pubmed]
Effects of intracerebroventricular administration of D,L-2-amino-5-phosphonovaleric acid, an N-methyl-D-aspartate receptor antagonist, on luteininizing hormone release in ovariectomized lambs. Hileman, S.M., Schillo, K.K., Estienne, M.J. Biol. Reprod. (1992) [Pubmed]
Transient effects of MK-801 administration on secretion of luteinizing hormone and prolactin in ovariectomized and estradiol-treated sheep. Jiang, H., Haglof, S.A., Malven, P.V. Life Sci. (1997) [Pubmed]
Effect of dexamethasone treatment on maturational changes in the NMDA receptor in sheep brain. McGowan, J.E., Sysyn, G., Petersson, K.H., Sadowska, G.B., Mishra, O.P., Delivoria-Papadopoulos, M., Stonestreet, B.S. J. Neurosci. (2000) [Pubmed]

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