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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

scrib  -  scribbled

Drosophila melanogaster

Synonyms: 0424/05, CG31082, CG42614, CG43398, CG5462, ...
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High impact information on scrib

  • We used analysis of variance to partition variation in transcript abundance between males and females and between smi genotypes and to determine the genotype-by-sex interaction [1].
  • Mutations in Drosophila scribble (scrib), which encodes a multi-PDZ (PSD-95, Discs-large and ZO-1) and leucine-rich-repeat protein, cause aberrant cell shapes and loss of the monolayer organization of embryonic epithelia [2].
  • Loss of scrib function results in the misdistribution of apical proteins and adherens junctions to the basolateral cell surface, but basolateral protein localization remains intact [2].
  • Scrib is localized to the epithelial septate junction, the analogue of the vertebrate tight junction, at the boundary of the apical and basolateral cell surfaces [2].
  • We show that the tumor suppressors lethal giant larvae (lgl) and discs-large (dlg) have identical effects on all three epithelia, and that scrib also acts as a tumor suppressor [3].

Biological context of scrib


Anatomical context of scrib


Co-localisations of scrib

  • We also show that at Drosophila synapses DLG colocalizes with SCRIB and that this colocalization is likely to be mediated by direct interactions between GUKH and the PDZ2 domain of SCRIB [10].

Other interactions of scrib

  • Previously, we identified through P[lArB]-element mutagenesis a smell impaired (smi) mutant, smi21F, with odorant-specific defects in avoidance responses [11].
  • scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila [12].

Analytical, diagnostic and therapeutic context of scrib

  • Quantitative complementation tests of mutations at these coregulated genes with the smi mutations showed that in most cases (67%) epistatic interactions for olfactory behavior mirrored epistasis at the level of transcription, thus identifying new candidate genes regulating olfactory behavior [1].


  1. The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome. Anholt, R.R., Dilda, C.L., Chang, S., Fanara, J.J., Kulkarni, N.H., Ganguly, I., Rollmann, S.M., Kamdar, K.P., Mackay, T.F. Nat. Genet. (2003) [Pubmed]
  2. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Bilder, D., Perrimon, N. Nature (2000) [Pubmed]
  3. Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Bilder, D., Li, M., Perrimon, N. Science (2000) [Pubmed]
  4. Scribble is essential for olfactory behavior in Drosophila melanogaster. Ganguly, I., Mackay, T.F., Anholt, R.R. Genetics (2003) [Pubmed]
  5. Differential expression of two scribble isoforms during Drosophila embryogenesis. Li, M., Marhold, J., Gatos, A., Török, I., Mechler, B.M. Mech. Dev. (2001) [Pubmed]
  6. Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Humbert, P., Russell, S., Richardson, H. Bioessays (2003) [Pubmed]
  7. The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo. Grifoni, D., Garoia, F., Schimanski, C.C., Schmitz, G., Laurenti, E., Galle, P.R., Pession, A., Cavicchi, S., Strand, D. Oncogene (2004) [Pubmed]
  8. Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble. Roche, J.P., Packard, M.C., Moeckel-Cole, S., Budnik, V. J. Neurosci. (2002) [Pubmed]
  9. A junctional problem of apical proportions: epithelial tube-size control by septate junctions in the Drosophila tracheal system. Wu, V.M., Beitel, G.J. Curr. Opin. Cell Biol. (2004) [Pubmed]
  10. Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein. Mathew, D., Gramates, L.S., Packard, M., Thomas, U., Bilder, D., Perrimon, N., Gorczyca, M., Budnik, V. Curr. Biol. (2002) [Pubmed]
  11. Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogaster. Rollmann, S.M., Mackay, T.F., Anholt, R.R. J. Neurobiol. (2005) [Pubmed]
  12. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. Brumby, A.M., Richardson, H.E. EMBO J. (2003) [Pubmed]
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