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Gene Review

Gsdma3  -  gasdermin A3

Mus musculus

Synonyms: Bsk, Dfl, Fgn, Gasdermin-3, Gasdermin-A3, ...
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Disease relevance of Gsdm3


High impact information on Gsdm3


Biological context of Gsdm3

  • These findings suggest that Bsk/Iyk might play a role in inhibiting cell proliferation, transducing cytokine-induced cytotoxicity and regulating hormone production of endocrine pancreatic cells [4].
  • The Bsk/IykY497/504F cells displayed a decreased cell growth rate, parallelled by an augmentation of the fraction of cells in G1-phase [5].

Anatomical context of Gsdm3


Associations of Gsdm3 with chemical compounds

  • Role of the Bsk/Iyk non-receptor tyrosine kinase for the control of growth and hormone production in RINm5F cells [4].

Other interactions of Gsdm3

  • These data ruled out the hypothesis that Bsk phenotype results from a recombination event between K12 and mHa 1, 2, 3 and 4 [1].

Analytical, diagnostic and therapeutic context of Gsdm3


  1. Characterization of Bsk mice: I. The Bsk mutation does not involve a recombination of cornea-specific keratin 12 and skin-specific hair keratin genes. Shiraishi, A., Kao, C.W., Ishizaki, M., Zhang, Z., Converse, R.L., Tseng, S.C., Svoboda, K.K., Kao, W.W. Curr. Eye Res. (1998) [Pubmed]
  2. Mutations in gasdermin 3 cause aberrant differentiation of the hair follicle and sebaceous gland. Lunny, D.P., Weed, E., Nolan, P.M., Marquardt, A., Augustin, M., Porter, R.M. J. Invest. Dermatol. (2005) [Pubmed]
  3. The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. Runkel, F., Marquardt, A., Stoeger, C., Kochmann, E., Simon, D., Kohnke, B., Korthaus, D., Wattler, F., Fuchs, H., Hrabé de Angelis, M., Stumm, G., Nehls, M., Wattler, S., Franz, T., Augustin, M. Genomics (2004) [Pubmed]
  4. Role of the Bsk/Iyk non-receptor tyrosine kinase for the control of growth and hormone production in RINm5F cells. Annerén, C., Welsh, M. Growth Factors (2000) [Pubmed]
  5. Mutation of C-terminal tyrosine residues Y497/Y504 of the Src-family member Bsk/Iyk decreases NIH3T3 cell proliferation. Oberg-Welsh, C., Annerén, C., Welsh, M. Growth Factors (1998) [Pubmed]
  6. Role of tyrosine kinase signaling for beta-cell replication and survival. Welsh, M., Annerén, C., Lindholm, C., Kriz, V., Oberg-Welsh, C. Ups. J. Med. Sci. (2000) [Pubmed]
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