The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MYL1  -  myosin, light chain 1, alkali; skeletal, fast

Homo sapiens

Synonyms: MLC1/MLC3, MLC1F, MLC1F/MLC3F, MLC3F, Myosin light chain 1/3, skeletal muscle isoform, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MYL1

  • Improved method for the determination of phospholipase A2 catalytic activity concentration in human serum and ascites [1].

High impact information on MYL1

  • We now demonstrate that an 85-kDa polypeptide which possesses sequence homology to and chemical, physical, immunological, and chromatographic similarities with phosphofructokinase (PFK) specifically interacts with the 40-kDa phospholipase A2 catalytic subunit and represents the putative protein regulatory element identified in previous work [2].
  • We have recently localized the gene encoding the fast skeletal muscle alkali light-chain isoforms MLC1F and MLC3F (HGM symbol, MYL1) to human chromosome 2q32.1-qter (Cohen-Haguenauer 1988) [3].
  • The fact that IDH1 and the MLC1F/MLC3F gene are closely linked on chromosome 1 in the mouse and map to the same region of human chromosome 2 in man indicates, that these chromosomes have a conserved region of homology between them and that the human 3.7-kb TaqI fragment corresponds indeed to a functional gene [4].
  • Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter [4].
  • These cis-acting regulatory modules, including the MLC1F and 3F promoter regions and two skeletal muscle enhancers, control tissue-specificity, cell or fibre-type specificity, and the spatiotemporal regulation of gene expression, including positional information [5].

Biological context of MYL1

  • Here we report DNA sequence and RNA blotting analyses that demonstrate that these cDNAs represent transcripts encoding human MLC3F and MLC1Sb [6].

Anatomical context of MYL1


Analytical, diagnostic and therapeutic context of MYL1

  • In all satellite cell cultures, only the four fast-type light chains (MLC1emb, MLC1F, MLC2F, and MLC3F) were synthesized and no slow myosin light chains were ever detected [9].
  • Immunoprecipitation of dissociated V1 domains using isoform-specific antibodies showed that V1 domains consist of either V-ATPase A1 or A2 catalytic subunit isoforms [10].


  1. Improved method for the determination of phospholipase A2 catalytic activity concentration in human serum and ascites. Schädlich, H.R., Büchler, M., Beger, H.G. J. Clin. Chem. Clin. Biochem. (1987) [Pubmed]
  2. The specific association of a phosphofructokinase isoform with myocardial calcium-independent phospholipase A2. Implications for the coordinated regulation of phospholipolysis and glycolysis. Hazen, S.L., Gross, R.W. J. Biol. Chem. (1993) [Pubmed]
  3. Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4). Cohen-Haguenauer, O., Barton, P.J., Van Cong, N., Cohen, A., Masset, M., Buckingham, M., Frézal, J. Hum. Genet. (1989) [Pubmed]
  4. Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. Cohen-Haguenauer, O., Barton, P.J., Nguyen, V.C., Serero, S., Gross, M.S., Jegou-Foubert, C., de Tand, M.F., Robert, B., Buckingham, M., Frézal, J. Hum. Genet. (1988) [Pubmed]
  5. Modular regulation of the MLC1F/3F gene and striated muscle diversity. Kelly, R.G., Buckingham, M.E. Microsc. Res. Tech. (2000) [Pubmed]
  6. Sequence and expression of human myosin alkali light chain isoforms. Wade, R., Feldman, D., Gunning, P., Kedes, L. Mol. Cell. Biochem. (1989) [Pubmed]
  7. Phospholipases A2 in gastric juice of Helicobacter pylori--positive and negative individuals. Huhtinen, H.T., Grönroos, J.M., Haapamäki, M.M., Nevalainen, T.J. Clin. Chem. Lab. Med. (1999) [Pubmed]
  8. Fiber type characteristics and myosin light chain expression in a world champion shot putter. Billeter, R., Jostarndt-Fögen, K., Günthör, W., Hoppeler, H. International journal of sports medicine. (2003) [Pubmed]
  9. Clones of human satellite cells can express in vitro both fast and slow myosin heavy chains. Edom, F., Mouly, V., Barbet, J.P., Fiszman, M.Y., Butler-Browne, G.S. Dev. Biol. (1994) [Pubmed]
  10. Two isoforms of the A subunit of the vacuolar H(+)-ATPase in Lycopersicon esculentum: highly similar proteins but divergent patterns of tissue localization. Bageshwar, U.K., Taneja-Bageshwar, S., Moharram, H.M., Binzel, M.L. Planta (2005) [Pubmed]
WikiGenes - Universities