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MYL1  -  myosin, light chain 1, alkali; skeletal, fast

Homo sapiens

Synonyms: MLC1/MLC3, MLC1F, MLC1F/MLC3F, MLC3F, Myosin light chain 1/3, skeletal muscle isoform, ...
 
 
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Disease relevance of MYL1

  • Improved method for the determination of phospholipase A2 catalytic activity concentration in human serum and ascites [1].
 

High impact information on MYL1

  • We now demonstrate that an 85-kDa polypeptide which possesses sequence homology to and chemical, physical, immunological, and chromatographic similarities with phosphofructokinase (PFK) specifically interacts with the 40-kDa phospholipase A2 catalytic subunit and represents the putative protein regulatory element identified in previous work [2].
  • We have recently localized the gene encoding the fast skeletal muscle alkali light-chain isoforms MLC1F and MLC3F (HGM symbol, MYL1) to human chromosome 2q32.1-qter (Cohen-Haguenauer 1988) [3].
  • The fact that IDH1 and the MLC1F/MLC3F gene are closely linked on chromosome 1 in the mouse and map to the same region of human chromosome 2 in man indicates, that these chromosomes have a conserved region of homology between them and that the human 3.7-kb TaqI fragment corresponds indeed to a functional gene [4].
  • Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter [4].
  • These cis-acting regulatory modules, including the MLC1F and 3F promoter regions and two skeletal muscle enhancers, control tissue-specificity, cell or fibre-type specificity, and the spatiotemporal regulation of gene expression, including positional information [5].
 

Biological context of MYL1

  • Here we report DNA sequence and RNA blotting analyses that demonstrate that these cDNAs represent transcripts encoding human MLC3F and MLC1Sb [6].
 

Anatomical context of MYL1

 

Analytical, diagnostic and therapeutic context of MYL1

  • In all satellite cell cultures, only the four fast-type light chains (MLC1emb, MLC1F, MLC2F, and MLC3F) were synthesized and no slow myosin light chains were ever detected [9].
  • Immunoprecipitation of dissociated V1 domains using isoform-specific antibodies showed that V1 domains consist of either V-ATPase A1 or A2 catalytic subunit isoforms [10].

References

  1. Improved method for the determination of phospholipase A2 catalytic activity concentration in human serum and ascites. Schädlich, H.R., Büchler, M., Beger, H.G. J. Clin. Chem. Clin. Biochem. (1987) [Pubmed]
  2. The specific association of a phosphofructokinase isoform with myocardial calcium-independent phospholipase A2. Implications for the coordinated regulation of phospholipolysis and glycolysis. Hazen, S.L., Gross, R.W. J. Biol. Chem. (1993) [Pubmed]
  3. Chromosomal assignment of two myosin alkali light-chain genes encoding the ventricular/slow skeletal muscle isoform and the atrial/fetal muscle isoform (MYL3, MYL4). Cohen-Haguenauer, O., Barton, P.J., Van Cong, N., Cohen, A., Masset, M., Buckingham, M., Frézal, J. Hum. Genet. (1989) [Pubmed]
  4. Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. Cohen-Haguenauer, O., Barton, P.J., Nguyen, V.C., Serero, S., Gross, M.S., Jegou-Foubert, C., de Tand, M.F., Robert, B., Buckingham, M., Frézal, J. Hum. Genet. (1988) [Pubmed]
  5. Modular regulation of the MLC1F/3F gene and striated muscle diversity. Kelly, R.G., Buckingham, M.E. Microsc. Res. Tech. (2000) [Pubmed]
  6. Sequence and expression of human myosin alkali light chain isoforms. Wade, R., Feldman, D., Gunning, P., Kedes, L. Mol. Cell. Biochem. (1989) [Pubmed]
  7. Phospholipases A2 in gastric juice of Helicobacter pylori--positive and negative individuals. Huhtinen, H.T., Grönroos, J.M., Haapamäki, M.M., Nevalainen, T.J. Clin. Chem. Lab. Med. (1999) [Pubmed]
  8. Fiber type characteristics and myosin light chain expression in a world champion shot putter. Billeter, R., Jostarndt-Fögen, K., Günthör, W., Hoppeler, H. International journal of sports medicine. (2003) [Pubmed]
  9. Clones of human satellite cells can express in vitro both fast and slow myosin heavy chains. Edom, F., Mouly, V., Barbet, J.P., Fiszman, M.Y., Butler-Browne, G.S. Dev. Biol. (1994) [Pubmed]
  10. Two isoforms of the A subunit of the vacuolar H(+)-ATPase in Lycopersicon esculentum: highly similar proteins but divergent patterns of tissue localization. Bageshwar, U.K., Taneja-Bageshwar, S., Moharram, H.M., Binzel, M.L. Planta (2005) [Pubmed]
 
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