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Gene Review

MLC1  -  Mlc1p

Saccharomyces cerevisiae S288c

Synonyms: Calmodulin-like myosin light chain MLC1, G3080, Myosin light chain 1, Myosin-2 light chain, YGL106W
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High impact information on MLC1


Biological context of MLC1


Anatomical context of MLC1


Associations of MLC1 with chemical compounds

  • In the presence of both Ca(2+) and a peptide synthesized to mimic the CaM binding domain on myosin light chain kinase, MLCK-22p, the solution structures of these chimeric CaMs take a similar compact globular shape but their interactions are quite different [13].
  • Electron-density maps for two of the complexes (Mlc1p-IQ4 and Mlc1p-IQ2,3) were obtained from multiple anomalous dispersion (MAD) experiments based on selenomethionine derivatives [14].
  • Both calmodulins activated muscle myosin light chain kinase and pea NAD+ kinase in a Ca2+-dependent manner, and the activities were inhibited by trifluoperazine or chlorpromazine [15].
  • These ameba gene segments were homologous to myosin light chain kinases, protein kinase C, phosphorylase b kinase, and kinases that regulate glucose repression in yeast and cell growth in mammalian cells [16].

Physical interactions of MLC1


Other interactions of MLC1


Analytical, diagnostic and therapeutic context of MLC1


  1. Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications. Terrak, M., Wu, G., Stafford, W.F., Lu, R.C., Dominguez, R. EMBO J. (2003) [Pubmed]
  2. Mlc1p promotes septum closure during cytokinesis via the IQ motifs of the vesicle motor Myo2p. Wagner, W., Bielli, P., Wacha, S., Ragnini-Wilson, A. EMBO J. (2002) [Pubmed]
  3. Mlc1p is a light chain for the unconventional myosin Myo2p in Saccharomyces cerevisiae. Stevens, R.C., Davis, T.N. J. Cell Biol. (1998) [Pubmed]
  4. Essential myosin light chain as a target for caspase-3 in failing myocardium. Moretti, A., Weig, H.J., Ott, T., Seyfarth, M., Holthoff, H.P., Grewe, D., Gillitzer, A., Bott-Flügel, L., Schömig, A., Ungerer, M., Laugwitz, K.L. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. A myosin light chain mediates the localization of the budding yeast IQGAP-like protein during contractile ring formation. Shannon, K.B., Li, R. Curr. Biol. (2000) [Pubmed]
  6. Structural Basis for the Interaction of the Myosin Light Chain Mlc1p with the Myosin V Myo2p IQ Motifs. Pennestri, M., Melino, S., Contessa, G.M., Casavola, E.C., Paci, M., Ragnini-Wilson, A., Cicero, D.O. J. Biol. Chem. (2007) [Pubmed]
  7. Yeast myosin light chain, Mlc1p, interacts with both IQGAP and class II myosin to effect cytokinesis. Boyne, J.R., Yosuf, H.M., Bieganowski, P., Brenner, C., Price, C. J. Cell. Sci. (2000) [Pubmed]
  8. The sequence of the dictyostelium myo J heavy chain gene predicts a novel, dimeric, unconventional myosin with a heavy chain molecular mass of 258 kDa. Hammer, J.A., Jung, G. J. Biol. Chem. (1996) [Pubmed]
  9. Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA. Surks, H.K., Richards, C.T., Mendelsohn, M.E. J. Biol. Chem. (2003) [Pubmed]
  10. Gain of function mutations for yeast calmodulin and calcium dependent regulation of protein kinase activity. Lukas, T.J., Collinge, M., Haiech, J., Watterson, D.M. Biochim. Biophys. Acta (1994) [Pubmed]
  11. Myosin light chain phosphorylation does not increase during yeast phagocytosis by macrophages. de Lanerolle, P., Gorgas, G., Li, X., Schluns, K. J. Biol. Chem. (1993) [Pubmed]
  12. Intracellular interaction of myosin light chain kinase with macrophage migration inhibition factor (MIF) in endothelium. Wadgaonkar, R., Dudek, S.M., Zaiman, A.L., Linz-McGillem, L., Verin, A.D., Nurmukhambetova, S., Romer, L.H., Garcia, J.G. J. Cell. Biochem. (2005) [Pubmed]
  13. Solution X-ray scattering data show structural differences among chimeras of yeast and chicken calmodulin: implications for structure and function. Yokouchi, T., Nogami, H., Izumi, Y., Yoshino, H., Nakashima, K., Yazawa, M. Biochemistry (2003) [Pubmed]
  14. Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V. Terrak, M., Otterbein, L.R., Wu, G., Palecanda, L.A., Lu, R.C., Dominguez, R. Acta Crystallogr. D Biol. Crystallogr. (2002) [Pubmed]
  15. Properties of calcium-dependent regulatory proteins from fungi and yeast. Nakamura, T., Fujita, K., Eguchi, Y., Yazawa, M. J. Biochem. (1984) [Pubmed]
  16. Molecular cloning of a rac family protein kinase and identification of a serine/threonine protein kinase gene family of Entamoeba histolytica. Que, X., Samuelson, J., Reed, S. Mol. Biochem. Parasitol. (1993) [Pubmed]
  17. GTP drives myosin light chain 1 interaction with the class V myosin Myo2 IQ motifs via a Sec2 RabGEF-mediated pathway. Bielli, P., Casavola, E.C., Biroccio, A., Urbani, A., Ragnini-Wilson, A. Mol. Microbiol. (2006) [Pubmed]
  18. Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains. Kollmar, M. BMC Genomics (2006) [Pubmed]
  19. Structure of the light chain-binding domain of myosin V. Terrak, M., Rebowski, G., Lu, R.C., Grabarek, Z., Dominguez, R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
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