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Gene Review

ada  -  adenosine deaminase

Xenopus (Silurana) tropicalis

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High impact information on ada

  • The RNA-editing enzyme adenosine deaminase that acts on RNA (ADAR1) deaminates adenosines to inosines in double-stranded RNA substrates [1].
  • Purification and properties of double-stranded RNA-specific adenosine deaminase from calf thymus [2].
  • Here we describe studies of double-stranded RNA (dsRNA) adenosine deaminase in Xenopus laevis, in particular during meiotic maturation, the period during which a stage VI oocyte matures to an egg [3].
  • The 5' end of this RNA mapped to the transcription initiation site for the ADA gene, and its 3' terminus mapped 7 nt downstream of the translation initiation codon within exon 1 [4].
  • We have previously shown that a transcription arrest site near the 5' end of the murine adenosine deaminase (ADA) gene is significantly involved in the regulation of ADA gene expression [4].

Anatomical context of ada

  • To facilitate the analysis of this transcription arrest site, we have analyzed the transcription products from cloned ADA gene fragments injected into Xenopus laevis oocytes [4].

Associations of ada with chemical compounds

  • A double-stranded RNA-specific adenosine deaminase, which converts adenosine to inosine, has been purified to homogeneity from calf thymus [2].

Analytical, diagnostic and therapeutic context of ada


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