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Gene Review

AAH1  -  adenine deaminase

Saccharomyces cerevisiae S288c

Synonyms: AAH, ADE, Adenine aminohydrolase, Adenine deaminase, N1208, ...
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Disease relevance of AAH1


High impact information on AAH1

  • An adenosine deaminase that generates inosine at the wobble position of tRNAs [3].
  • The bacterial tRNA adenosine deaminase (TadA) generates inosine by deaminating the adenosine residue at the wobble position of tRNA(Arg-2) [4].
  • We have isolated three deletion mutants, srb10, srb11 and saf1 (ybr280c) affecting AAH1 expression during post-diauxic growth and in early stationary phase [5].
  • The adenine deaminase encoding gene AAH1 is among the most precociously and tightly downregulated gene upon entry into quiescence [5].
  • We show that AAH1 downregulation is not specifically due to glucose exhaustion but is a more general response to nutrient limitation [5].

Biological context of AAH1


Anatomical context of AAH1

  • Among the ribofuranosyl derivatives, 1-deazaadenosine is the best inhibitor, its Ki ranging between 3.5 x 10(-7) and 4 x 10(-5) M for ADA from erythrocytes and Takadiastase respectively [1].

Associations of AAH1 with chemical compounds


Analytical, diagnostic and therapeutic context of AAH1


  1. Inhibition of adenosine deaminase from several sources by deaza derivatives of adenosine and EHNA. Lupidi, G., Cristalli, G., Marmocchi, F., Riva, F., Grifantini, M. J. Enzym. Inhib. (1985) [Pubmed]
  2. Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. Losey, H.C., Ruthenburg, A.J., Verdine, G.L. Nat. Struct. Mol. Biol. (2006) [Pubmed]
  3. An adenosine deaminase that generates inosine at the wobble position of tRNAs. Gerber, A.P., Keller, W. Science (1999) [Pubmed]
  4. Crystal structure of tRNA adenosine deaminase (TadA) from Aquifex aeolicus. Kuratani, M., Ishii, R., Bessho, Y., Fukunaga, R., Sengoku, T., Shirouzu, M., Sekine, S., Yokoyama, S. J. Biol. Chem. (2005) [Pubmed]
  5. Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p. Escusa, S., Camblong, J., Galan, J.M., Pinson, B., Daignan-Fornier, B. Mol. Microbiol. (2006) [Pubmed]
  6. Adenosine deaminase from Saccharomyces cerevisiae: kinetics and interaction with transition and ground state inhibitors. Lupidi, G., Marmocchi, F., Falasca, M., Venardi, G., Cristalli, G., Grifantini, M., Whitehead, E., Riva, F. Biochim. Biophys. Acta (1992) [Pubmed]
  7. Adenosine accumulation in Saccharomyces cerevisiae cultured in medium containing low levels of adenine. Laten, H.M., Valentine, P.J., van Kast, C.A. J. Bacteriol. (1986) [Pubmed]
  8. Skp1-Cullin-F-box-dependent degradation of Aah1p requires its interaction with the F-box protein Saf1p. Escusa, S., Laporte, D., Massoni, A., Boucherie, H., Dautant, A., Daignan-Fornier, B. J. Biol. Chem. (2007) [Pubmed]
  9. Adenosine deaminase from Saccharomyces cerevisiae: purification and characterization. Marmocchi, F., Lupidi, G., Venardi, G., Riva, F. Biochem. Int. (1987) [Pubmed]
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