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Gene Review

TRAT1  -  T cell receptor associated transmembrane...

Homo sapiens

Synonyms: HSPC062, T-cell receptor-associated transmembrane adapter 1, T-cell receptor-interacting molecule, TCRIM, TRIM, ...
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Disease relevance of TRAT1

  • The long-term prevalence of the Trim strain suggests that adenovirus type 8 has greater genetic stability than the other adenovirus types studied to date [1].
  • 394 uncomplicated falciparum malaria cases studied at Trat and Chanthaburi malaria clinics, eastern Thailand, were allocated at random to receive either one of the seven following regimens: A) artesunate 600 mg over 2 days and mefloquine 1,250 mg in divided doses [2].
  • Reversal of T cell anergy in leprosy patients: in vitro presentation with Mycobacterium leprae antigens using murabutide and Trat peptide in liposomal delivery [3].

High impact information on TRAT1

  • In this study we sought to identify how soluble forms of M. leprae antigen(s) or particulate (liposome) delivery of the same antigens with two immunomodulators Murabutide and T cell peptide of Trat protein influence the transcription of IL-2 gene in anergic T cells of lepromatous patients [4].
  • The third group, 196 patients from provinces with high-level mefloquine resistance (Tak, Ranong, Chanthaburi and Trat), received 25 mg/kg of mefloquine plus 12 mg/kg artesunate [5].
  • The antioxidant and membrane effects of dimer (Dim) and trimer (Trim) procyanidins isolated from cocoa (Theobroma cacao) (B- and C-bonded) and peanut (Arachis hypogea L.) skin (A-bonded) were evaluated in phosphatidyl choline liposomes [6].
  • RESULTS: All materials exhibited exotherm release ranging from 5.1 to 12.7 degrees C. Trim gave a peak temperature that was not significantly lower (p > 0.05) than those of Protemp 3 Garant and Luxatemp, but fast set Temphase showed a significantly higher (p < 0.05) peak temperature than the other materials [7].
  • MATERIAL AND METHODS: Polymethyl methacrylate (Jet), polyethyl methacrylate (Snap), polyvinylethyl methacrylate (Trim), Bis-acrylic composite (Protemp II), and a VLP urethane dimethacrylate (Revotec LC) were compared with respect to their exothermic reaction properties during polymerization [8].

Chemical compound and disease context of TRAT1

  • A total of 99 patients with uncomplicated falciparum malaria who attended the malaria clinic in Bo Rai, Trat Province were treated with a single oral dose of MSP 3 tablets (Fansimef; equivalent to 750 mg of mefloquine) concurrently with primaquine (30 mg) [9].

Anatomical context of TRAT1


Associations of TRAT1 with chemical compounds

  • MATERIALS AND METHODS: Twenty identical three-unit FPDs of the PMMA materials Trim and Cronsin and the composite-based materials Protemp 3 Garant, Protemp Garant, Luxatemp, and Tempofit were cemented on Co-Cr alloy dies [11].
  • RESULTS: For specimens immersed in water, the color change of bis-acryl-methacrylate-based provisional materials (Integrity and Luxatemp) was significantly less than that of 3 methyl/ethyl methacrylate-based provisional materials (Trim II, Alike, and Duralay) (P<.002) [12].
  • Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand [13].
  • The results showed that Kind had a slight color change delta E* = -1.72, Trim demonstrated the most color change delta E* = -13.84, while the remaining resins demonstrated a noticeable change in color due to in vitro aging [14].

Analytical, diagnostic and therapeutic context of TRAT1

  • Asymmetry of funnel plot of estimated test accuracy against corresponding precision for each meta-analysis was assessed by three statistical methods: rank correlation method, regression analysis, and Trim and Fill method [15].
  • The study was conducted in four villages namely Wang Thong, Khao Thong in Chanthaburi, and Manow and Khow in Trat by using a cross-sectional survey [16].
  • MATERIAL AND METHODS: A total of 105 disc-shaped specimens (20+/-0.1 mm by 1+/-0.05 mm) were fabricated with 5 provisional prosthodontic materials: polyethyl methacrylate resins (Trim II), polymethyl methacrylate resins (Duralay; Alike), and bis-acryl methacrylate resin (Luxatemp; Integrity), according to manufacturers' instructions (n=21) [12].


  1. Three adenovirus type 8 genome types defined by restriction enzyme analysis: prototype stability in geographically separated populations. Kemp, M.C., Hierholzer, J.C. J. Clin. Microbiol. (1986) [Pubmed]
  2. A comparative study of artesunate and artemether in combination with mefloquine on multidrug resistant falciparum malaria in eastern Thailand. Thimasarn, K., Sirichaisinthop, J., Chanyakhun, P., Palananth, C., Rooney, W. Southeast Asian J. Trop. Med. Public Health (1997) [Pubmed]
  3. Reversal of T cell anergy in leprosy patients: in vitro presentation with Mycobacterium leprae antigens using murabutide and Trat peptide in liposomal delivery. Sridevi, K., Khanna, N., Chattree, V., Pal, P.C., Haq, W., Rao, D.N. Int. Immunopharmacol. (2003) [Pubmed]
  4. Alterations in T cell signal transduction by M. leprae antigens is associated with downregulation of second messengers PKC, calcium, calcineurin, MAPK and various transcription factors in leprosy patients. Chattree, V., Khanna, N., Rao, D.N. Mol. Immunol. (2007) [Pubmed]
  5. In vivo sensitivity monitoring of mefloquine monotherapy and artesunate-mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003. Vijaykadga, S., Rojanawatsirivej, C., Cholpol, S., Phoungmanee, D., Nakavej, A., Wongsrichanalai, C. Trop. Med. Int. Health (2006) [Pubmed]
  6. Antioxidant and membrane effects of procyanidin dimers and trimers isolated from peanut and cocoa. Verstraeten, S.V., Hammerstone, J.F., Keen, C.L., Fraga, C.G., Oteiza, P.I. J. Agric. Food Chem. (2005) [Pubmed]
  7. Exotherm behavior of the polymer-based provisional crown and fixed partial denture materials. Kim, S.H., Watts, D.C. Dental materials : official publication of the Academy of Dental Materials. (2004) [Pubmed]
  8. Comparison of temperature increase in the pulp chamber during the polymerization of materials used for the direct fabrication of provisional restorations. Michalakis, K., Pissiotis, A., Hirayama, H., Kang, K., Kafantaris, N. The Journal of prosthetic dentistry (2006) [Pubmed]
  9. Mefloquine levels in patients with mefloquine resistant Plasmodium falciparum in the eastern part of Thailand. Karbwang, J., Na Bangchang, K., Thimasarn, K., Rooney, W., Bunnag, D., Harinasuta, T. Southeast Asian J. Trop. Med. Public Health (1993) [Pubmed]
  10. Proteomic profiling of surface proteins on Th1 and Th2 cells. Loyet, K.M., Ouyang, W., Eaton, D.L., Stults, J.T. J. Proteome Res. (2005) [Pubmed]
  11. Fracture resistance of PMMA and resin matrix composite-based interim FPD materials. Lang, R., Rosentritt, M., Behr, M., Handel, G. The International journal of prosthodontics. (2003) [Pubmed]
  12. Color stability of provisional prosthodontic materials. Sham, A.S., Chu, F.C., Chai, J., Chow, T.W. The Journal of prosthetic dentistry. (2004) [Pubmed]
  13. Comparative trial on the response of Plasmodium falciparum to halofantrine and mefloquine in Trat Province, eastern Thailand. Ketrangsee, S., Vijaykadga, S., Yamokgul, P., Jatapadma, S., Thimasarn, K., Rooney, W. Southeast Asian J. Trop. Med. Public Health (1992) [Pubmed]
  14. In vitro color stability of provisional restorations. Yaman, P., Razzoog, M., Brandau, H.E. American journal of dentistry. (1989) [Pubmed]
  15. Asymmetric funnel plots and publication bias in meta-analyses of diagnostic accuracy. Song, F., Khan, K.S., Dinnes, J., Sutton, A.J. International journal of epidemiology. (2002) [Pubmed]
  16. Behaviors in self-prevention of malaria among mobile population in east Thailand. Butraporn, P., Prasittisuk, C., Krachaiklin, S., Chareonjai, P. Southeast Asian J. Trop. Med. Public Health (1995) [Pubmed]
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