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Gene Review:

GPRC5B - G protein-coupled receptor, class C, group...

Homo sapiens

Synonyms: A-69G12.1, G-protein coupled receptor family C group 5 member B, RAIG-2, RAIG2, Retinoic acid-induced gene 2 protein

Robbins, M.J. et al., Robbins, M.J. et al., Bräuner-Osborne, H. et al.

Robbins, Charles, Harrison, Pangalos, Bräuner-Osborne, Krogsgaard-Larsen,

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High impact information on GPRC5B

Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C) [1].
Distribution profiles of mRNA expression obtained by semiquantitative Taq-Man PCR analysis showed RAIG-2 to be predominantly expressed in human brain areas and RAIG-3 to be predominantly expressed in peripheral tissues [1].
In addition, expression of RAIG-2 and RAIG-3 mRNA was increased following treatment with all-trans-retinoic acid in a manner similar to that previously described for RAIG-1 [1].
Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain [2].
The transcript, entitled GPRC5B, was cloned from an expressed sequence tag clone that contained the entire open reading frame of the transcript encoding a protein of 395 amino acids [2].

Biological context of GPRC5B

Transient transfection experiments in HEK239T cells using these constructs demonstrated RAIG-2 and RAIG-3 expression at the cell surface [1].
Finally, RAIG-2 was mapped to chromosome 16p12 (D16S405-D16S3045) and RAIG-3 to chromosome 17q25 (D17S1352-D17S785) [1].

Anatomical context of GPRC5B

GPRC5B mRNA is widely expressed in peripheral and central tissues with highest abundance in kidney, pancreas, and testis [2].
Localisation of the GPRC5B receptor in the rat brain and spinal cord [3].
It has been shown human GPRC5B mRNA is predominantly expressed in the central nervous system [3].
In addition, immunohistochemical analysis of GPRC5B in rat brain and spinal cord demonstrated receptor expression in many areas, with highest levels of immunoreactivity in the neocortex, all subfields of the hippocampus, the granule cell layer of the cerebellum and throughout the spinal cord [3].

Analytical, diagnostic and therapeutic context of GPRC5B

Western blot analysis, using affinity-purified antisera specific to GPRC5B, identified a protein migrating at approximately 68 kDa, close to the predicted molecular weight for GPRC5B [3].

References

Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Robbins, M.J., Michalovich, D., Hill, J., Calver, A.R., Medhurst, A.D., Gloger, I., Sims, M., Middlemiss, D.N., Pangalos, M.N. Genomics (2000) [Pubmed]
Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Bräuner-Osborne, H., Krogsgaard-Larsen, P. Genomics (2000) [Pubmed]
Localisation of the GPRC5B receptor in the rat brain and spinal cord. Robbins, M.J., Charles, K.J., Harrison, D.C., Pangalos, M.N. Brain Res. Mol. Brain Res. (2002) [Pubmed]

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