The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GPRC5A  -  G protein-coupled receptor, class C, group...

Homo sapiens

Synonyms: G-protein coupled receptor family C group 5 member A, GPCR5A, Orphan G-protein-coupling receptor PEIG-1, PEIG-1, RAI3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GPRC5A


High impact information on GPRC5A


Biological context of GPRC5A


Anatomical context of GPRC5A


Associations of GPRC5A with chemical compounds


Regulatory relationships of GPRC5A

  • Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target [6].

Other interactions of GPRC5A


Analytical, diagnostic and therapeutic context of GPRC5A

  • Using quantitative reverse transcription-PCR (RT-PCR), we documented increased expression of RAI3 in 19 of 25 primary breast cancers and in 6 of 11 breast-cancer cell lines examined, by comparison with normal mammary-gland tissue [3].


  1. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. Cheng, Y., Lotan, R. J. Biol. Chem. (1998) [Pubmed]
  2. Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors. Nevrivy, D.J., Peterson, V.J., Avram, D., Ishmael, J.E., Hansen, S.G., Dowell, P., Hruby, D.E., Dawson, M.I., Leid, M. J. Biol. Chem. (2000) [Pubmed]
  3. Identification of RAI3 as a therapeutic target for breast cancer. Nagahata, T., Sato, T., Tomura, A., Onda, M., Nishikawa, K., Emi, M. Endocr. Relat. Cancer (2005) [Pubmed]
  4. All-trans retinoic acid induced gene expression and growth inhibition in head and neck cancer cell lines. Copper, M.P., Klaassen, I., Brakenhoff, R.H., Cloos, J., Snow, G.B., Braakhuis, B.J. Oral Oncol. (1997) [Pubmed]
  5. Retinoic acid-induced gene expression in normal and leukemic myeloid cells. Murtaugh, M.P., Dennison, O., Stein, J.P., Davies, P.J. J. Exp. Med. (1986) [Pubmed]
  6. Integrative genomics revealed RAI3 is a cell growth-promoting gene and a novel P53 transcriptional target. Wu, Q., Ding, W., Mirza, A., Van Arsdale, T., Wei, I., Bishop, W.R., Basso, A., McClanahan, T., Luo, L., Kirschmeier, P., Gustafson, E., Hernandez, M., Liu, S. J. Biol. Chem. (2005) [Pubmed]
  7. Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. Nadauld, L.D., Sandoval, I.T., Chidester, S., Yost, H.J., Jones, D.A. J. Biol. Chem. (2004) [Pubmed]
  8. The retinoic acid-responsive proline-rich protein is identified in promyeloleukemic HL-60 cells. Inagaki, T., Suzuki, S., Miyamoto, T., Takeda, T., Yamashita, K., Komatsu, A., Yamauchi, K., Hashizume, K. J. Biol. Chem. (2003) [Pubmed]
  9. Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression. Hirano, M., Zang, L., Oka, T., Ito, Y., Shimada, Y., Nishimura, Y., Tanaka, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  10. Granulocyte macrophage colony-stimulating factor enhances retinoic acid-induced gene expression. Shimizu, T., Esaki, L., Mizuno, H., Takeda, K. J. Leukoc. Biol. (2006) [Pubmed]
  11. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Robbins, M.J., Michalovich, D., Hill, J., Calver, A.R., Medhurst, A.D., Gloger, I., Sims, M., Middlemiss, D.N., Pangalos, M.N. Genomics (2000) [Pubmed]
  12. Control of retinoic acid receptor heterodimerization by ligand-induced structural transitions. A novel mechanism of action for retinoid antagonists. Depoix, C., Delmotte, M.H., Formstecher, P., Lefebvre, P. J. Biol. Chem. (2001) [Pubmed]
  13. Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter. Jiang, S.Y., Wu, M.S., Chen, L.M., Hung, M.W., Lin, H.E., Chang, G.G., Chang, T.C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  14. Purification and functional characterization of a novel protein encoded by a retinoic acid-induced gene, RA28. Liu, Z., Luo, A., Wang, G., Wang, X., Wu, M. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
WikiGenes - Universities