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Gene Review

Bok  -  BCL2-related ovarian killer

Mus musculus

Synonyms: AI847676, AU021146, Apoptosis activator Mtd, Bcl-2-related ovarian killer protein, Mtd, ...
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High impact information on Bok

  • Taken together these results demonstrate that Bok represents a cell cycle-regulated pro-apoptotic member of the Bcl-2 family, which may predispose growing cells to chemotherapeutic treatment [1].
  • We find that the mouse promoter contains a conserved E2F binding site (-43 to -49) and that a Bok promoter-driven luciferase reporter is activated by serum stimulation dependent on this site [1].
  • Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis [1].
  • In adult tissues, Mtd mRNA was predominantly detected in the brain, liver, and lymphoid tissues, while in the embryo Mtd mRNA was detected in the liver, thymus, lung, and intestinal epithelium [2].
  • Expression of Mtd promoted the death of primary sensory neurons, 293T cells and HeLa cells, indicating that Mtd is a proapoptotic protein [2].

Anatomical context of Bok


Associations of Bok with chemical compounds


Other interactions of Bok


Analytical, diagnostic and therapeutic context of Bok


  1. Bok, Bcl-2-related Ovarian Killer, Is Cell Cycle-regulated and Sensitizes to Stress-induced Apoptosis. Rodriguez, J.M., Glozak, M.A., Ma, Y., Cress, W.D. J. Biol. Chem. (2006) [Pubmed]
  2. Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL. Inohara, N., Ekhterae, D., Garcia, I., Carrio, R., Merino, J., Merry, A., Chen, S., Núñez, G. J. Biol. Chem. (1998) [Pubmed]
  3. The expression of Bok is regulated by serum in HC11 mammary epithelial cells. Ha, S.H., Lee, S.R., Lee, T.H., Kim, Y.M., Baik, M.G., Choi, Y.J. Mol. Cells (2001) [Pubmed]
  4. Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction. Lein, E.S., Callaway, E.M., Albright, T.D., Gage, F.H. J. Comp. Neurol. (2005) [Pubmed]
  5. Intracellular mechanisms of ovarian cell apoptosis. Hsu, S.Y., Hsueh, A.J. Mol. Cell. Endocrinol. (1998) [Pubmed]
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