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Gene Review

PLCL1  -  phospholipase C-like 1

Homo sapiens

Synonyms: Inactive phospholipase C-like protein 1, PLC-L, PLC-L1, PLCE, PLCL, ...
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Disease relevance of PLCL1

  • Eight weeks after implantation of vascular patches tissue-engineered with BMCs and PGA/PLCL scaffolds, the vascular patches remained patent with no sign of thrombosis, stenosis, or dilatation [1].
  • Treatment of nevus of Ota with the Candela PLDL and PLTL lasers [2].

High impact information on PLCL1

  • Since its homology to phospholipase C genes suggests the involvement of the PLC-L gene in inositol phospholipid-based intracellular signaling cascade, it is possible that aberrant expression of the PLC-L gene contributes to the genesis or progression of human lung carcinoma [3].
  • Because SM-mediated signal transduction is initiated via the hydrolysis of an integral membrane phospholipid by a phospholipase C-like enzyme (sphingomyelinase) to yield lipids which modulate protein kinase C activity, the SM and phosphatidylinositol (PI) signaling pathways share certain similarities [4].
  • Tissue-engineered vascular patches (15 mm wide x 30 mm long) were fabricated by seeding vascular cells onto PGA/PLCL scaffolds and implanted into the inferior vena cava of bone marrow donor dogs [1].
  • RESULTS: Compared with PLCL scaffolds, PGA/PLCL scaffolds exhibited tensile mechanical properties more similar to those of dog inferior vena cava [1].
  • Splicing sites for exons 4 to 12, which encode both conserved phospholipase-C-like and catalytic domains of the Src-like PTKs, arise exactly at the same position for the human lck, human c-src and c-fgr genes [5].

Anatomical context of PLCL1

  • In this study, the level of type II collagen mRNA expression was increased by a continuous dynamic compression at 10% compressive strain and 0.1 Hz in chondrocytes seeded in a biodegradable, elastomeric scaffold, poly(L-lactide-co-epsilon-caprolactone) (PLCL) [6].
  • The PLCL sponges and rabbit articular cartilage tissue were subjected to compression/unloading tests (0.1 and 0.005 Hz) at 5 kPa, and stress relaxation tests at 10, 30, and 50% strain [7].
  • In this study, the mechanical and degradation properties of a novel 75:25 poly(l-lactide-co-epsilon-caprolactone) (PLCL) thin film, as well as, the effects of different surface structures on stem cell adherence and resistance to shear stress was investigated [8].
  • The hemolytic activity was distinct from induced phospholipase A-like and phospholipase C-like activities that were detected in immune hemolymph and which were inhibited by EDTA [9].
  • Human umbilical vein endothelial cells (HUVECs) were highly elongated and well spread on the fibrous surfaces of fabrics made of PLCL with 5 wt % or 10 wt % collagen [10].

Associations of PLCL1 with chemical compounds

  • Nanoscale-fiber fabrics with PLCL 50/50 (approx. 0.3 or 1.2 microm in diameter) were electrospun using 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as a solvent [11].
  • Electrospun microfiber fabrics with different compositions of PLCL (mol% in feed; 70/30, 50/50, and 30/70), poly(L-lactide) (PLL) and poly(epsilon-caprolactone) (PCL) were obtained using methylene chloride (MC) as a solvent [11].
  • Increasing the lactide:glycolide ratio (50:50-100:0) resulted in a progressive decrease in the release rate of 5-FU. poly-(lactide-co-caprolactone) (PLCL) microspheres released 5-FU more rapidly compared to PLGA systems (k(1) = 0.254-0.259/h) [12].
  • Treatment of recalcitrant verrucae with both the ultrapulse CO2 and PLDL pulsed dye lasers [13].
  • A viscous PLCL solution was spun as a gel-phase under swirl-flow conditions and was subsequently fabricated to produce a tubular fibrous scaffold on a rotating cylindrical shaft in a methanol solution [14].

Analytical, diagnostic and therapeutic context of PLCL1

  • Fabrication of a new tubular fibrous PLCL scaffold for vascular tissue engineering [14].
  • Surface characterization using noncontact profilometry, contact angles, and scanning electron microscopy (SEM) showed that the three PU surfaces, PLDL, and Thermanox have different properties [15].


  1. Preliminary experience with tissue engineering of a venous vascular patch by using bone marrow-derived cells and a hybrid biodegradable polymer scaffold. Cho, S.W., Jeon, O., Lim, J.E., Gwak, S.J., Kim, S.S., Choi, C.Y., Kim, D.I., Kim, B.S. J. Vasc. Surg. (2006) [Pubmed]
  2. Treatment of nevus of Ota with the Candela PLDL and PLTL lasers. Mixter, R.C., Carson, L.V., Walton, B.J., Gerson, R.M. Plast. Reconstr. Surg. (1996) [Pubmed]
  3. Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma. Kohno, T., Otsuka, T., Takano, H., Yamamoto, T., Hamaguchi, M., Terada, M., Yokota, J. Hum. Mol. Genet. (1995) [Pubmed]
  4. Sphingosine-mediated phosphatidylinositol metabolism and calcium mobilization. Chao, C.P., Laulederkind, S.J., Ballou, L.R. J. Biol. Chem. (1994) [Pubmed]
  5. Structure of the human lck gene: differences in genomic organisation within src-related genes affect only N-terminal exons. Rouer, E., Van Huynh, T., Lavareda de Souza, S., Lang, M.C., Fischer, S., Benarous, R. Gene (1989) [Pubmed]
  6. Mechanical compressive loading stimulates the activity of proximal region of human COL2A1 gene promoter in transfected chondrocytes. Xie, J., Han, Z.Y., Matsuda, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  7. Mechano-Active Scaffold Design Based on Microporous Poly(L-lactide-co-epsilon-caprolactone) for Articular Cartilage Tissue Engineering: Dependence of Porosity on Compression Force-Applied Mechanical Behaviors. Xie, J., Ihara, M., Jung, Y., Kwon, I.K., Kim, S.H., Kim, Y.H., Matsuda, T. Tissue engineering. (2006) [Pubmed]
  8. Characterization of 75:25 Poly(l-lactide-co-epsilon-caprolactone) Thin Films for the Endoluminal Delivery of Adipose-Derived Stem Cells to Abdominal Aortic Aneurysms. Burks, C.A., Bundy, K., Fotuhi, P., Alt, E. Tissue Eng. (2006) [Pubmed]
  9. The hemolytic activity of Galleria mellonella hemolymph. Phipps, D.J., Chadwick, J.S., Leeder, R.G., Aston, W.P. Dev. Comp. Immunol. (1989) [Pubmed]
  10. Co-electrospun nanofiber fabrics of poly(L-lactide-co-epsilon-caprolactone) with type I collagen or heparin. Kwon, I.K., Matsuda, T. Biomacromolecules (2005) [Pubmed]
  11. Electrospun nano- to microfiber fabrics made of biodegradable copolyesters: structural characteristics, mechanical properties and cell adhesion potential. Kwon, I.K., Kidoaki, S., Matsuda, T. Biomaterials (2005) [Pubmed]
  12. Development of a respirable, sustained release microcarrier for 5-fluorouracil I: In vitro assessment of liposomes, microspheres, and lipid coated nanoparticles. Hitzman, C.J., Elmquist, W.F., Wattenberg, L.W., Wiedmann, T.S. Journal of pharmaceutical sciences. (2006) [Pubmed]
  13. Treatment of recalcitrant verrucae with both the ultrapulse CO2 and PLDL pulsed dye lasers. Geronemus, R.G., Kauvar, A.N., McDaniel, D.H. Plast. Reconstr. Surg. (1998) [Pubmed]
  14. Fabrication of a new tubular fibrous PLCL scaffold for vascular tissue engineering. Kim, S.H., Kwon, J.H., Chung, M.S., Chung, E., Jung, Y., Kim, S.H., Kim, Y.H. Journal of biomaterials science. Polymer edition (2006) [Pubmed]
  15. Biodegradable polyurethane cytocompatibility to fibroblasts and staphylococci. Harris, L.G., Gorna, K., Gogolewski, S., Richards, R.G. Journal of biomedical materials research. Part A. (2006) [Pubmed]
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