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Gene Review

MOB1A  -  MOB kinase activator 1A

Homo sapiens

Synonyms: C2orf6, FLJ10788, FLJ11595, MATS1, MOB1, ...
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Psychiatry related information on MOBK1B

  • Picture symbols and Talking Mats, a visual communication framework, were used to assist the participants with communication disability [1].

High impact information on MOBK1B

  • Loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth [2].
  • The point mutations of highly conserved residues within the N-terminal domain of NDR reduced NDR kinase activity as well as human MOB1 binding [3].
  • Here Mats Wahlgren, Johan Carlson, Rachonee Udomsangpetch and Peter Perlmonn discuss a novel cytoodherence phenomenon which may be o f great importance in this context, that is, the spontaneous binding o f uninfected erythrocytes to those infected with late-stage parasites (trophozoites/schizonts) [4].
  • In this article Mats Johansson and Kenneth Söderhäll discuss the function of the proPO system in cellular immune reactions in crustaceans and in particular the role of a protein with a molecular mass of 76 kDa, which has been shown to be involved in the communication between the different blood cell types of crayfish [5].
  • Strand S0 binds to the core domain in an intramolecular manner across a putative Dbf2 binding site mapped by Mob1 temperature-sensitive alleles and NMR binding experiments [6].

Biological context of MOBK1B

  • Therefore, we suggest a potential in vivo mechanism of LATS1 activation through rapid recruitment to the plasma membrane by hMOB1 followed by multi-site phosphorylation, thereby providing insight into the molecular regulation of the LATS tumour suppressor [7].
  • Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways [8].
  • In vivo functional analysis demonstrates that Mob1 mutants that target helix H0 or its reciprocal binding site are biologically compromised [6].
  • We used eight microsatellite loci to explore clonality and fine-scale patch structure in C. membranacea at six sites on the Canary Islands. Mats were always composites of many individuals; not single, large clones [9].

Analytical, diagnostic and therapeutic context of MOBK1B


  1. Perceptions of communication between people with communication disability and general practice staff. Murphy, J. Health expectations : an international journal of public participation in health care and health policy. (2006) [Pubmed]
  2. Control of cell proliferation and apoptosis by mob as tumor suppressor, mats. Lai, Z.C., Wei, X., Shimizu, T., Ramos, E., Rohrbaugh, M., Nikolaidis, N., Ho, L.L., Li, Y. Cell (2005) [Pubmed]
  3. Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein. Bichsel, S.J., Tamaskovic, R., Stegert, M.R., Hemmings, B.A. J. Biol. Chem. (2004) [Pubmed]
  4. Why do Plasmodium falciparumm-infected erythrocytes form spontaneous erythrocyte rosettes? Wahlgren, M., Carlson, J., Udomsangpetch, R., Perlmann, P. Parasitol. Today (Regul. Ed.) (1989) [Pubmed]
  5. Cellular immunity in crustaceans and the proPO system. Johansson, M.W., Soderhall, K. Parasitol. Today (Regul. Ed.) (1989) [Pubmed]
  6. Structural and Functional Analysis of Saccharomyces cerevisiae Mob1. Mrkobrada, S., Boucher, L., Ceccarelli, D.F., Tyers, M., Sicheri, F. J. Mol. Biol. (2006) [Pubmed]
  7. The human tumour suppressor LATS1 is activated by human MOB1 at the membrane. Hergovich, A., Schmitz, D., Hemmings, B.A. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  8. Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways. Stavridi, E.S., Harris, K.G., Huyen, Y., Bothos, J., Verwoerd, P.M., Stayrook, S.E., Pavletich, N.P., Jeffrey, P.D., Luca, F.C. Structure (Camb.) (2003) [Pubmed]
  9. The contribution of haploids, diploids and clones to fine-scale population structure in the seaweed Cladophoropsis membranacea (Chlorophyta). van der Strate, H.J., van de Zande, L., Stam, W.T., Olsen, J.L. Mol. Ecol. (2002) [Pubmed]
  10. Involvement of M3 cholinergic receptor signal transduction pathway in regulation of the expression of chemokine MOB-1, MCP-1 genes in pancreatic acinar cells. Zheng, H., Chen, D., Zhang, J., Tian, Y. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. (2004) [Pubmed]
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