Psychiatry related information on MOBK1B

• Picture symbols and Talking Mats, a visual communication framework, were used to assist the participants with communication disability [1].

High impact information on MOBK1B

• Loss of Mats function results in increased cell proliferation, defective apoptosis, and induction of tissue overgrowth [2].
• The point mutations of highly conserved residues within the N-terminal domain of NDR reduced NDR kinase activity as well as human MOB1 binding [3].
• Here Mats Wahlgren, Johan Carlson, Rachonee Udomsangpetch and Peter Perlmonn discuss a novel cytoodherence phenomenon which may be o f great importance in this context, that is, the spontaneous binding o f uninfected erythrocytes to those infected with late-stage parasites (trophozoites/schizonts) [4].
• In this article Mats Johansson and Kenneth Söderhäll discuss the function of the proPO system in cellular immune reactions in crustaceans and in particular the role of a protein with a molecular mass of 76 kDa, which has been shown to be involved in the communication between the different blood cell types of crayfish [5].
• Strand S0 binds to the core domain in an intramolecular manner across a putative Dbf2 binding site mapped by Mob1 temperature-sensitive alleles and NMR binding experiments [6].

Biological context of MOBK1B

• Therefore, we suggest a potential in vivo mechanism of LATS1 activation through rapid recruitment to the plasma membrane by hMOB1 followed by multi-site phosphorylation, thereby providing insight into the molecular regulation of the LATS tumour suppressor [7].
• Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways [8].
• In vivo functional analysis demonstrates that Mob1 mutants that target helix H0 or its reciprocal binding site are biologically compromised [6].
• We used eight microsatellite loci to explore clonality and fine-scale patch structure in C. membranacea at six sites on the Canary Islands. Mats were always composites of many individuals; not single, large clones [9].

Analytical, diagnostic and therapeutic context of MOBK1B

• We cloned a human Mob1 family member, Mob1A, and determined its three-dimensional structure by X-ray crystallography [8].
• The MOB-1 and MCP-1 mRNA expression was detected by using RT-PCR [10].

References